Occupational prestige, social mobility and the association with lung cancer in men

Thomas Behrens; Isabelle Groß; Jack Siemiatycki; David I Conway; Ann Olsson; Isabelle Stücker; Florence Guida; Karl-Heinz Jöckel; Hermann Pohlabeln; Wolfgang Ahrens; Irene Brüske; Heinz-Erich Wichmann; Per Gustavsson; Dario Consonni; Franco Merletti; Lorenzo Richiardi; Lorenzo Simonato; Cristina Fortes; Marie-Elise Parent; John McLaughlin; Paul Demers; Maria Teresa Landi; Neil Caporaso; David Zaridze; Neonila Szeszenia-Dabrowska; Peter Rudnai; Jolanta Lissowska; Eleonora Fabianova; Adonina Tardón; John K Field; Rodica Stanescu Dumitru; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Hans Kromhout; Roel Vermeulen; Paolo Boffetta; Kurt Straif; Joachim Schüz; Jan Hovanec; Benjamin Kendzia; Beate Pesch; Thomas Brüning

doi:10.1186/s12885-016-2432-9

Occupational prestige, social mobility and the association with lung cancer in men

Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl-Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz-Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie-Elise Parent, John McLaughlinPaul Demers, Maria Teresa Landi, Neil Caporaso, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, Adonina Tardón, John K Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Jan Hovanec, Benjamin Kendzia, Beate Pesch, Thomas Brüning

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory.

METHODS: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results.

RESULTS: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories.

CONCLUSIONS: Our results indicate that occupational prestige is independently associated with lung cancer among men.

Original language	English
Article number	395
Number of pages	12
Journal	BMC Cancer
Volume	16
DOIs	https://doi.org/10.1186/s12885-016-2432-9
Publication status	Published - 7 Jul 2016

Keywords

Life course
occupational history
social prestige
socio-economic status
SYNERGY
transitions

Access to Document

10.1186/s12885-016-2432-9

OccupationalFinal published version, 757 KB

Cite this

Behrens, T., Groß, I., Siemiatycki, J., Conway, D. I., Olsson, A., Stücker, I., Guida, F., Jöckel, K.-H., Pohlabeln, H., Ahrens, W., Brüske, I., Wichmann, H.-E., Gustavsson, P., Consonni, D., Merletti, F., Richiardi, L., Simonato, L., Fortes, C., Parent, M.-E., ... Brüning, T. (2016). Occupational prestige, social mobility and the association with lung cancer in men. BMC Cancer, 16, Article 395. https://doi.org/10.1186/s12885-016-2432-9

@article{57068e48604f4cbeb360523eefca2fa9,

title = "Occupational prestige, social mobility and the association with lung cancer in men",

abstract = "BACKGROUND: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory.METHODS: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results.RESULTS: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories.CONCLUSIONS: Our results indicate that occupational prestige is independently associated with lung cancer among men.",

keywords = "Life course, occupational history, social prestige, socio-economic status, SYNERGY, transitions",

author = "Thomas Behrens and Isabelle Gro{\ss} and Jack Siemiatycki and Conway, {David I} and Ann Olsson and Isabelle St{\"u}cker and Florence Guida and Karl-Heinz J{\"o}ckel and Hermann Pohlabeln and Wolfgang Ahrens and Irene Br{\"u}ske and Heinz-Erich Wichmann and Per Gustavsson and Dario Consonni and Franco Merletti and Lorenzo Richiardi and Lorenzo Simonato and Cristina Fortes and Marie-Elise Parent and John McLaughlin and Paul Demers and Landi, {Maria Teresa} and Neil Caporaso and David Zaridze and Neonila Szeszenia-Dabrowska and Peter Rudnai and Jolanta Lissowska and Eleonora Fabianova and Adonina Tard{\'o}n and Field, {John K} and Dumitru, {Rodica Stanescu} and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Hans Kromhout and Roel Vermeulen and Paolo Boffetta and Kurt Straif and Joachim Sch{\"u}z and Jan Hovanec and Benjamin Kendzia and Beate Pesch and Thomas Br{\"u}ning",

year = "2016",

month = jul,

day = "7",

doi = "10.1186/s12885-016-2432-9",

language = "English",

volume = "16",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central",

}

Behrens, T, Groß, I, Siemiatycki, J, Conway, DI, Olsson, A, Stücker, I, Guida, F, Jöckel, K-H, Pohlabeln, H, Ahrens, W, Brüske, I, Wichmann, H-E, Gustavsson, P, Consonni, D, Merletti, F, Richiardi, L, Simonato, L, Fortes, C, Parent, M-E, McLaughlin, J, Demers, P, Landi, MT, Caporaso, N, Zaridze, D, Szeszenia-Dabrowska, N, Rudnai, P, Lissowska, J, Fabianova, E, Tardón, A, Field, JK, Dumitru, RS, Bencko, V, Foretova, L, Janout, V, Kromhout, H , Vermeulen, R, Boffetta, P, Straif, K, Schüz, J, Hovanec, J, Kendzia, B, Pesch, B & Brüning, T 2016, 'Occupational prestige, social mobility and the association with lung cancer in men', BMC Cancer, vol. 16, 395. https://doi.org/10.1186/s12885-016-2432-9

TY - JOUR

T1 - Occupational prestige, social mobility and the association with lung cancer in men

AU - Behrens, Thomas

AU - Groß, Isabelle

AU - Siemiatycki, Jack

AU - Conway, David I

AU - Olsson, Ann

AU - Stücker, Isabelle

AU - Guida, Florence

AU - Jöckel, Karl-Heinz

AU - Pohlabeln, Hermann

AU - Ahrens, Wolfgang

AU - Brüske, Irene

AU - Wichmann, Heinz-Erich

AU - Gustavsson, Per

AU - Consonni, Dario

AU - Merletti, Franco

AU - Richiardi, Lorenzo

AU - Simonato, Lorenzo

AU - Fortes, Cristina

AU - Parent, Marie-Elise

AU - McLaughlin, John

AU - Demers, Paul

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Rudnai, Peter

AU - Lissowska, Jolanta

AU - Fabianova, Eleonora

AU - Tardón, Adonina

AU - Field, John K

AU - Dumitru, Rodica Stanescu

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Kromhout, Hans

AU - Vermeulen, Roel

AU - Boffetta, Paolo

AU - Straif, Kurt

AU - Schüz, Joachim

AU - Hovanec, Jan

AU - Kendzia, Benjamin

AU - Pesch, Beate

AU - Brüning, Thomas

PY - 2016/7/7

Y1 - 2016/7/7

N2 - BACKGROUND: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory.METHODS: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results.RESULTS: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories.CONCLUSIONS: Our results indicate that occupational prestige is independently associated with lung cancer among men.

AB - BACKGROUND: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory.METHODS: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results.RESULTS: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories.CONCLUSIONS: Our results indicate that occupational prestige is independently associated with lung cancer among men.

KW - Life course

KW - occupational history

KW - social prestige

KW - socio-economic status

KW - SYNERGY

KW - transitions

U2 - 10.1186/s12885-016-2432-9

DO - 10.1186/s12885-016-2432-9

M3 - Article

C2 - 27388894

SN - 1471-2407

VL - 16

JO - BMC Cancer

JF - BMC Cancer

M1 - 395

ER -

Occupational prestige, social mobility and the association with lung cancer in men

Abstract

Keywords

Access to Document

Fingerprint

Cite this