Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

Tom Koeman; Leo J Schouten; Piet A van den Brandt; Pauline Slottje; Anke Huss; Susan Peters; Hans Kromhout; Roel Vermeulen

doi:10.1002/ajim.22462

Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

Tom Koeman, Leo J Schouten, Piet A van den Brandt, Pauline Slottje, Anke Huss, Susan Peters, Hans Kromhout, Roel Vermeulen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Occupational exposures may be associated with non-vascular dementia.

METHODS: We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.

RESULTS: Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.

CONCLUSIONS: Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. © 2015 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	625-635
Number of pages	11
Journal	American Journal of Industrial Medicine
Volume	58
Issue number	6
DOIs	https://doi.org/10.1002/ajim.22462
Publication status	Published - 2015

Bibliographical note

Keywords

cohort
dementia
Alzheimer’s disease
occupation
extremely low frequency magnetic fields
pesticides
metals
solvents
diesel motor exhaust

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10.1002/ajim.22462

OccupationalFinal published version, 298 KBLicence: Taverne

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title = "Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study",

abstract = "BACKGROUND: Occupational exposures may be associated with non-vascular dementia.METHODS: We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.RESULTS: Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.CONCLUSIONS: Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. {\textcopyright} 2015 Wiley Periodicals, Inc.",

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author = "Tom Koeman and Schouten, {Leo J} and {van den Brandt}, {Piet A} and Pauline Slottje and Anke Huss and Susan Peters and Hans Kromhout and Roel Vermeulen",

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year = "2015",

doi = "10.1002/ajim.22462",

language = "English",

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T1 - Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

AU - Koeman, Tom

AU - Schouten, Leo J

AU - van den Brandt, Piet A

AU - Slottje, Pauline

AU - Huss, Anke

AU - Peters, Susan

AU - Kromhout, Hans

AU - Vermeulen, Roel

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Occupational exposures may be associated with non-vascular dementia.METHODS: We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.RESULTS: Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.CONCLUSIONS: Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. © 2015 Wiley Periodicals, Inc.

AB - BACKGROUND: Occupational exposures may be associated with non-vascular dementia.METHODS: We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.RESULTS: Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.CONCLUSIONS: Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. © 2015 Wiley Periodicals, Inc.

KW - cohort

KW - dementia

KW - Alzheimer’s disease

KW - occupation

KW - extremely low frequency magnetic fields

KW - pesticides

KW - metals

KW - solvents

KW - diesel motor exhaust

U2 - 10.1002/ajim.22462

DO - 10.1002/ajim.22462

M3 - Article

C2 - 25943788

SN - 0271-3586

VL - 58

SP - 625

EP - 635

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

IS - 6

ER -

Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

Abstract

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Keywords

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