Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

B.A. Bassig; L. Zhang; X. Tang; R. Vermeulen; M. Shen; M.T. Smith; C. Qiu; Y. Ge; Z. Ji; B. Reiss; H.D. Hosgood 3rd; S. Liu; R. Bagni; W. Guo; M. Purdue; W. Hu; F. Yue; L. Li; H. Huang; N. Rothman; Q. Lan

doi:10.1002/em.21789

Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

B.A. Bassig, L. Zhang, X. Tang, R. Vermeulen, M. Shen, M.T. Smith, C. Qiu, Y. Ge, Z. Ji, B. Reiss, H.D. Hosgood 3rd, S. Liu, R. Bagni, W. Guo, M. Purdue, W. Hu, F. Yue, L. Li, H. Huang, N. RothmanQ. Lan

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P = 0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to

Original language	English
Pages (from-to)	450-454
Number of pages	5
Journal	Environmental and Molecular Mutagenesis
Volume	54
Issue number	6
DOIs	https://doi.org/10.1002/em.21789
Publication status	Published - 2013

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Bassig, B. A., Zhang, L., Tang, X., Vermeulen, R., Shen, M., Smith, M. T., Qiu, C., Ge, Y., Ji, Z., Reiss, B., Hosgood 3rd, H. D., Liu, S., Bagni, R., Guo, W., Purdue, M., Hu, W., Yue, F., Li, L., Huang, H., ... Lan, Q. (2013). Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha. Environmental and Molecular Mutagenesis, 54(6), 450-454. https://doi.org/10.1002/em.21789

@article{19583a860704479ea87d884d7c0e9ece,

title = "Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha",

abstract = "To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P = 0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to",

author = "B.A. Bassig and L. Zhang and X. Tang and R. Vermeulen and M. Shen and M.T. Smith and C. Qiu and Y. Ge and Z. Ji and B. Reiss and {Hosgood 3rd}, H.D. and S. Liu and R. Bagni and W. Guo and M. Purdue and W. Hu and F. Yue and L. Li and H. Huang and N. Rothman and Q. Lan",

year = "2013",

doi = "10.1002/em.21789",

language = "English",

volume = "54",

pages = "450--454",

journal = "Environmental and Molecular Mutagenesis",

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Bassig, BA, Zhang, L, Tang, X, Vermeulen, R, Shen, M, Smith, MT, Qiu, C, Ge, Y, Ji, Z, Reiss, B, Hosgood 3rd, HD, Liu, S, Bagni, R, Guo, W, Purdue, M, Hu, W, Yue, F, Li, L, Huang, H, Rothman, N & Lan, Q 2013, 'Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha', Environmental and Molecular Mutagenesis, vol. 54, no. 6, pp. 450-454. https://doi.org/10.1002/em.21789

TY - JOUR

T1 - Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

AU - Bassig, B.A.

AU - Zhang, L.

AU - Tang, X.

AU - Vermeulen, R.

AU - Shen, M.

AU - Smith, M.T.

AU - Qiu, C.

AU - Ge, Y.

AU - Ji, Z.

AU - Reiss, B.

AU - Hosgood 3rd, H.D.

AU - Liu, S.

AU - Bagni, R.

AU - Guo, W.

AU - Purdue, M.

AU - Hu, W.

AU - Yue, F.

AU - Li, L.

AU - Huang, H.

AU - Rothman, N.

AU - Lan, Q.

PY - 2013

Y1 - 2013

N2 - To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P = 0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to

AB - To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P = 0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to

U2 - 10.1002/em.21789

DO - 10.1002/em.21789

M3 - Article

SN - 0893-6692

VL - 54

SP - 450

EP - 454

JO - Environmental and Molecular Mutagenesis

JF - Environmental and Molecular Mutagenesis

IS - 6

ER -

Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

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