Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries

Madar Talibov; Monica Guxens; Eero Pukkala; Anke Huss; Hans Kromhout; Pauline Slottje; Jan Ivar Martinsen; Kristina Kjaerheim; Pär Sparén; Elisabete Weiderpass; Laufey Tryggvadottir; Sanni Uuksulainen; Roel Vermeulen

doi:10.1007/s10552-015-0600-x

Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries

Madar Talibov, Monica Guxens, Eero Pukkala, Anke Huss, Hans Kromhout, Pauline Slottje, Jan Ivar Martinsen, Kristina Kjaerheim, Pär Sparén, Elisabete Weiderpass, Laufey Tryggvadottir, Sanni Uuksulainen, Roel Vermeulen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA).

METHODS: We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices. We estimated hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) using conditional logistic regression adjusted for concurrent occupational exposures relevant for AML risk (e.g., benzene, ionizing radiation). We conducted sensitivity analyses with different assumptions to assess the robustness of our results.

RESULTS: Approximately 40 % of the subjects were ever occupationally exposed to low levels and 7 % to high levels of ELF-MF, whereas 18 % were ever at low risk and 15 % at high risk of electrical shocks. We did not observe an association between occupational exposure to neither ELF-MF nor electrical shocks and AML. The HR was 0.88 (95 % CI 0.77-1.01) for subjects with high levels of ELF-MF exposure and 0.94 (95 % CI 0.85-1.05) for subjects with high risk of electrical shocks as compared to those with background-level exposure. Results remained materially unchanged in sensitivity analyses with different assumptions.

CONCLUSION: Our results do not support an association between occupational ELF-MF or electric shock exposure and AML.

Original language	English
Pages (from-to)	1079-1085
Number of pages	7
Journal	Cancer Causes & Control
Volume	26
Issue number	8
DOIs	https://doi.org/10.1007/s10552-015-0600-x
Publication status	Published - 1 Aug 2015

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Talibov, M., Guxens, M., Pukkala, E., Huss, A., Kromhout, H., Slottje, P., Martinsen, J. I., Kjaerheim, K., Sparén, P., Weiderpass, E., Tryggvadottir, L., Uuksulainen, S., & Vermeulen, R. (2015). Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries. Cancer Causes & Control, 26(8), 1079-1085. https://doi.org/10.1007/s10552-015-0600-x

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title = "Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries",

abstract = "OBJECTIVE: We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA).METHODS: We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices. We estimated hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) using conditional logistic regression adjusted for concurrent occupational exposures relevant for AML risk (e.g., benzene, ionizing radiation). We conducted sensitivity analyses with different assumptions to assess the robustness of our results.RESULTS: Approximately 40 % of the subjects were ever occupationally exposed to low levels and 7 % to high levels of ELF-MF, whereas 18 % were ever at low risk and 15 % at high risk of electrical shocks. We did not observe an association between occupational exposure to neither ELF-MF nor electrical shocks and AML. The HR was 0.88 (95 % CI 0.77-1.01) for subjects with high levels of ELF-MF exposure and 0.94 (95 % CI 0.85-1.05) for subjects with high risk of electrical shocks as compared to those with background-level exposure. Results remained materially unchanged in sensitivity analyses with different assumptions.CONCLUSION: Our results do not support an association between occupational ELF-MF or electric shock exposure and AML.",

author = "Madar Talibov and Monica Guxens and Eero Pukkala and Anke Huss and Hans Kromhout and Pauline Slottje and Martinsen, {Jan Ivar} and Kristina Kjaerheim and P{\"a}r Spar{\'e}n and Elisabete Weiderpass and Laufey Tryggvadottir and Sanni Uuksulainen and Roel Vermeulen",

year = "2015",

month = aug,

day = "1",

doi = "10.1007/s10552-015-0600-x",

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Talibov, M, Guxens, M, Pukkala, E, Huss, A , Kromhout, H, Slottje, P, Martinsen, JI, Kjaerheim, K, Sparén, P, Weiderpass, E, Tryggvadottir, L, Uuksulainen, S & Vermeulen, R 2015, 'Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries', Cancer Causes & Control, vol. 26, no. 8, pp. 1079-1085. https://doi.org/10.1007/s10552-015-0600-x

TY - JOUR

T1 - Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries

AU - Talibov, Madar

AU - Guxens, Monica

AU - Pukkala, Eero

AU - Huss, Anke

AU - Kromhout, Hans

AU - Slottje, Pauline

AU - Martinsen, Jan Ivar

AU - Kjaerheim, Kristina

AU - Sparén, Pär

AU - Weiderpass, Elisabete

AU - Tryggvadottir, Laufey

AU - Uuksulainen, Sanni

AU - Vermeulen, Roel

PY - 2015/8/1

Y1 - 2015/8/1

N2 - OBJECTIVE: We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA).METHODS: We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices. We estimated hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) using conditional logistic regression adjusted for concurrent occupational exposures relevant for AML risk (e.g., benzene, ionizing radiation). We conducted sensitivity analyses with different assumptions to assess the robustness of our results.RESULTS: Approximately 40 % of the subjects were ever occupationally exposed to low levels and 7 % to high levels of ELF-MF, whereas 18 % were ever at low risk and 15 % at high risk of electrical shocks. We did not observe an association between occupational exposure to neither ELF-MF nor electrical shocks and AML. The HR was 0.88 (95 % CI 0.77-1.01) for subjects with high levels of ELF-MF exposure and 0.94 (95 % CI 0.85-1.05) for subjects with high risk of electrical shocks as compared to those with background-level exposure. Results remained materially unchanged in sensitivity analyses with different assumptions.CONCLUSION: Our results do not support an association between occupational ELF-MF or electric shock exposure and AML.

AB - OBJECTIVE: We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA).METHODS: We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices. We estimated hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) using conditional logistic regression adjusted for concurrent occupational exposures relevant for AML risk (e.g., benzene, ionizing radiation). We conducted sensitivity analyses with different assumptions to assess the robustness of our results.RESULTS: Approximately 40 % of the subjects were ever occupationally exposed to low levels and 7 % to high levels of ELF-MF, whereas 18 % were ever at low risk and 15 % at high risk of electrical shocks. We did not observe an association between occupational exposure to neither ELF-MF nor electrical shocks and AML. The HR was 0.88 (95 % CI 0.77-1.01) for subjects with high levels of ELF-MF exposure and 0.94 (95 % CI 0.85-1.05) for subjects with high risk of electrical shocks as compared to those with background-level exposure. Results remained materially unchanged in sensitivity analyses with different assumptions.CONCLUSION: Our results do not support an association between occupational ELF-MF or electric shock exposure and AML.

U2 - 10.1007/s10552-015-0600-x

DO - 10.1007/s10552-015-0600-x

M3 - Article

C2 - 25971677

SN - 0957-5243

VL - 26

SP - 1079

EP - 1085

JO - Cancer Causes & Control

JF - Cancer Causes & Control

IS - 8

ER -

Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries

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