Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium

Andrea 't Mannetje; Anneclaire J De Roos; Paolo Boffetta; Roel Vermeulen; Geza Benke; Lin Fritschi; Paul Brennan; Lenka Foretova; Marc Maynadié; Nikolaus Becker; Alexandra Nieters; Anthony Staines; Marcello Campagna; Brian Chiu; Jacqueline Clavel; Silvia de Sanjose; Patricia Hartge; Elizabeth A Holly; Paige Bracci; Martha S Linet; Alain Monnereau; Laurent Orsi; Mark P Purdue; Nathaniel Rothman; Qing Lan; Eleanor Kane; Adele Seniori Costantini; Lucia Miligi; John J Spinelli; Tongzhang Zheng; Pierluigi Cocco; Anne Kricker

doi:10.1289/ehp.1409294

Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium

Andrea 't Mannetje, Anneclaire J De Roos, Paolo Boffetta, Roel Vermeulen, Geza Benke, Lin Fritschi, Paul Brennan, Lenka Foretova, Marc Maynadié, Nikolaus Becker, Alexandra Nieters, Anthony Staines, Marcello Campagna, Brian Chiu, Jacqueline Clavel, Silvia de Sanjose, Patricia Hartge, Elizabeth A Holly, Paige Bracci, Martha S LinetAlain Monnereau, Laurent Orsi, Mark P Purdue, Nathaniel Rothman, Qing Lan, Eleanor Kane, Adele Seniori Costantini, Lucia Miligi, John J Spinelli, Tongzhang Zheng, Pierluigi Cocco, Anne Kricker

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Various occupations have been associated with an elevated NHL risk but results have been inconsistent across studies.

OBJECTIVES: To investigate occupational risk of non-Hodgkin lymphoma (NHL) and four common NHL subtypes with particular focus on occupations of a priori interest.

METHODS: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (OR), adjusted for center, age and sex were determined for NHL overall and the subtypes diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and peripheral T-cell lymphoma (PTCL).

RESULTS: We confirmed previously reported positive associations between NHL and farming occupations (field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19, 95% CI: 1.03, 1.37), and with specific occupations as women's hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype specific associations for DLBCL and CLL/SLL in women's hairdressers and for DLBCL and PTCL in textile workers.

CONCLUSIONS: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry-related exposures may contribute to NHL risk. Associations with women's hairdresser and textile occupations may be specific for certain NHL subtypes.

Original language	English
Pages (from-to)	396-405
Number of pages	10
Journal	Environmental Health Perspectives
Volume	124
Issue number	4
DOIs	https://doi.org/10.1289/ehp.1409294
Publication status	Published - Apr 2016

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't Mannetje, A., De Roos, A. J., Boffetta, P., Vermeulen, R., Benke, G., Fritschi, L., Brennan, P., Foretova, L., Maynadié, M., Becker, N., Nieters, A., Staines, A., Campagna, M., Chiu, B., Clavel, J., de Sanjose, S., Hartge, P., Holly, E. A., Bracci, P., ... Kricker, A. (2016). Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium. Environmental Health Perspectives, 124(4), 396-405. https://doi.org/10.1289/ehp.1409294

@article{278204479f6744359a924ff2cca3670b,

title = "Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium",

abstract = "BACKGROUND: Various occupations have been associated with an elevated NHL risk but results have been inconsistent across studies.OBJECTIVES: To investigate occupational risk of non-Hodgkin lymphoma (NHL) and four common NHL subtypes with particular focus on occupations of a priori interest.METHODS: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (OR), adjusted for center, age and sex were determined for NHL overall and the subtypes diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and peripheral T-cell lymphoma (PTCL).RESULTS: We confirmed previously reported positive associations between NHL and farming occupations (field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19, 95% CI: 1.03, 1.37), and with specific occupations as women's hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype specific associations for DLBCL and CLL/SLL in women's hairdressers and for DLBCL and PTCL in textile workers.CONCLUSIONS: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry-related exposures may contribute to NHL risk. Associations with women's hairdresser and textile occupations may be specific for certain NHL subtypes.",

author = "{'t Mannetje}, Andrea and {De Roos}, {Anneclaire J} and Paolo Boffetta and Roel Vermeulen and Geza Benke and Lin Fritschi and Paul Brennan and Lenka Foretova and Marc Maynadi{\'e} and Nikolaus Becker and Alexandra Nieters and Anthony Staines and Marcello Campagna and Brian Chiu and Jacqueline Clavel and {de Sanjose}, Silvia and Patricia Hartge and Holly, {Elizabeth A} and Paige Bracci and Linet, {Martha S} and Alain Monnereau and Laurent Orsi and Purdue, {Mark P} and Nathaniel Rothman and Qing Lan and Eleanor Kane and {Seniori Costantini}, Adele and Lucia Miligi and Spinelli, {John J} and Tongzhang Zheng and Pierluigi Cocco and Anne Kricker",

year = "2016",

month = apr,

doi = "10.1289/ehp.1409294",

language = "English",

volume = "124",

pages = "396--405",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "Public Health Services, US Dept of Health and Human Services",

number = "4",

}

't Mannetje, A, De Roos, AJ, Boffetta, P, Vermeulen, R, Benke, G, Fritschi, L, Brennan, P, Foretova, L, Maynadié, M, Becker, N, Nieters, A, Staines, A, Campagna, M, Chiu, B, Clavel, J, de Sanjose, S, Hartge, P, Holly, EA, Bracci, P, Linet, MS, Monnereau, A, Orsi, L, Purdue, MP, Rothman, N, Lan, Q, Kane, E, Seniori Costantini, A, Miligi, L, Spinelli, JJ, Zheng, T, Cocco, P & Kricker, A 2016, 'Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium', Environmental Health Perspectives, vol. 124, no. 4, pp. 396-405. https://doi.org/10.1289/ehp.1409294

TY - JOUR

T1 - Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium

AU - 't Mannetje, Andrea

AU - De Roos, Anneclaire J

AU - Boffetta, Paolo

AU - Vermeulen, Roel

AU - Benke, Geza

AU - Fritschi, Lin

AU - Brennan, Paul

AU - Foretova, Lenka

AU - Maynadié, Marc

AU - Becker, Nikolaus

AU - Nieters, Alexandra

AU - Staines, Anthony

AU - Campagna, Marcello

AU - Chiu, Brian

AU - Clavel, Jacqueline

AU - de Sanjose, Silvia

AU - Hartge, Patricia

AU - Holly, Elizabeth A

AU - Bracci, Paige

AU - Linet, Martha S

AU - Monnereau, Alain

AU - Orsi, Laurent

AU - Purdue, Mark P

AU - Rothman, Nathaniel

AU - Lan, Qing

AU - Kane, Eleanor

AU - Seniori Costantini, Adele

AU - Miligi, Lucia

AU - Spinelli, John J

AU - Zheng, Tongzhang

AU - Cocco, Pierluigi

AU - Kricker, Anne

PY - 2016/4

Y1 - 2016/4

N2 - BACKGROUND: Various occupations have been associated with an elevated NHL risk but results have been inconsistent across studies.OBJECTIVES: To investigate occupational risk of non-Hodgkin lymphoma (NHL) and four common NHL subtypes with particular focus on occupations of a priori interest.METHODS: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (OR), adjusted for center, age and sex were determined for NHL overall and the subtypes diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and peripheral T-cell lymphoma (PTCL).RESULTS: We confirmed previously reported positive associations between NHL and farming occupations (field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19, 95% CI: 1.03, 1.37), and with specific occupations as women's hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype specific associations for DLBCL and CLL/SLL in women's hairdressers and for DLBCL and PTCL in textile workers.CONCLUSIONS: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry-related exposures may contribute to NHL risk. Associations with women's hairdresser and textile occupations may be specific for certain NHL subtypes.

AB - BACKGROUND: Various occupations have been associated with an elevated NHL risk but results have been inconsistent across studies.OBJECTIVES: To investigate occupational risk of non-Hodgkin lymphoma (NHL) and four common NHL subtypes with particular focus on occupations of a priori interest.METHODS: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (OR), adjusted for center, age and sex were determined for NHL overall and the subtypes diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and peripheral T-cell lymphoma (PTCL).RESULTS: We confirmed previously reported positive associations between NHL and farming occupations (field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19, 95% CI: 1.03, 1.37), and with specific occupations as women's hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype specific associations for DLBCL and CLL/SLL in women's hairdressers and for DLBCL and PTCL in textile workers.CONCLUSIONS: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry-related exposures may contribute to NHL risk. Associations with women's hairdresser and textile occupations may be specific for certain NHL subtypes.

U2 - 10.1289/ehp.1409294

DO - 10.1289/ehp.1409294

M3 - Article

C2 - 26340796

SN - 0091-6765

VL - 124

SP - 396

EP - 405

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 4

ER -

Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium

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