Nuclear Magnetic Resonance-based modeling and refinement of protein three-dimensional structures and their complexes

G. Fuentes; A.D.J. van Dijk; A.M.J.J. Bonvin

doi:10.1007/978-1-59745-177-2_13

Nuclear Magnetic Resonance-based modeling and refinement of protein three-dimensional structures and their complexes

G. Fuentes, A.D.J. van Dijk, A.M.J.J. Bonvin

Dept of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Nuclear magnetic resonance (NMR) has become a well-established method to characterize the structures of biomolecules in solution. High-quality structures are now produced, thanks to both experimental and computational developments, allowing the use of new NMR parameters and improved protocols and force fields in structure calculation and refinement. In this chapter, we give a short overview of the various types of NMR data that can provide structural information, and then focus on the structure calculation methodology itself. We discuss and illustrate with tutorial examples both “classical” structure calculation and refinement approaches as well as more recently developed protocols for modeling biomolecular complexes.

Original language	Undefined/Unknown
Title of host publication	Molecular modeling of proteins
Editors	Andreas Kukol
Place of Publication	Totowa
Publisher	Humana Press
Pages	229-255
Number of pages	390
ISBN (Print)	978-1-58829-864-5
DOIs	https://doi.org/10.1007/978-1-59745-177-2_13
Publication status	Published - 2008

Publication series

Name	Methods in molecular biology
Number	443

Access to Document

10.1007/978-1-59745-177-2_13

546 (book chapter)
Open Access (free)
Final published version, 661 KB

Cite this

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Nuclear Magnetic Resonance-based modeling and refinement of protein three-dimensional structures and their complexes. / Fuentes, G.; van Dijk, A.D.J.; Bonvin, A.M.J.J.
Molecular modeling of proteins. ed. / Andreas Kukol. Totowa: Humana Press, 2008. p. 229-255 (Methods in molecular biology; No. 443).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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