Novel polymeric inhibitors of HCoV-NL63

Aleksandra Milewska, Justyna Ciejka, Kamil Kaminski, Anna Karewicz, Dorota Bielska, Slawomir Zeglen, Wojciech Karolak, Maria Nowakowska, Jan Potempa, Berend Jan Bosch, Krzysztof Pyrc, Krzysztof Szczubialka

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    The human coronavirus NL63 is generally classified as a common cold pathogen, though the infection may also result in severe lower respiratory tract diseases, especially in children, patients with underlying disease, and elderly. It has been previously shown that HCoV-NL63 is also one of the most important causes of croup in children. In the current manuscript we developed a set of polymer-based compounds showing prominent anticoronaviral activity. Polymers have been recently considered as promising alternatives to small molecule inhibitors, due to their intrinsic antimicrobial properties and ability to serve as matrices for antimicrobial compounds. Most of the antimicrobial polymers show antibacterial properties, while those with antiviral activity are much less frequent. A cationically modified chitosan derivative, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and hydrophobically-modified HTCC were shown to be potent inhibitors of HCoV-NL63 replication. Furthermore, both compounds showed prominent activity against murine hepatitis virus, suggesting broader anticoronaviral activity.

    Original languageEnglish
    Pages (from-to)112-121
    Number of pages10
    JournalAntiviral Research
    Volume97
    Issue number2
    DOIs
    Publication statusPublished - Feb 2013

    Bibliographical note

    Copyright © 2012 Elsevier B.V. All rights reserved.

    Keywords

    • Animals
    • Antiviral Agents
    • Cations
    • Cell Line
    • Chitosan
    • Coronavirus NL63, Human
    • Humans
    • Macaca mulatta
    • Murine hepatitis virus
    • Virus Replication

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