Abstract
Background: A striking proportion (25-45%) of chronic obstructive pulmonary disease (COPD) cases has never smoked. Yet, the biological pathways underlying non-smoking related COPD are still unknown. Genetic susceptibility to occupational exposures might play a key role. We therefore studied interactions between single nucleotide polymorphisms (SNPs) and occupational exposure to biological dust, mineral dust and gases/fumes on the level of FEV1 in never-smokers. Methods: Genome-wide SNP-by-occupational exposure interactions on the level of FEV1 were assessed in never-smokers from two independent general population-based cohorts, the LifeLines study (n=5070) and the VlagtweddeVlaardingen study (n=431). Effect estimates were meta-analyzed and significant SNPs selected based on a Bonferroni-corrected threshold of p
Original language | English |
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Journal | European Respiratory Journal |
Volume | 46 |
DOIs | |
Publication status | Published - 1 Sept 2015 |
Keywords
- interleukin 10
- transcription factor
- smoking
- human
- occupational exposure
- European
- society
- gene
- mineral dust
- chronic obstructive lung disease
- dust
- single nucleotide polymorphism
- exposure
- genetic susceptibility
- fume
- population
- genome
- lung function