Novel genes associated with the level of FEV1 in never-smokers in the context of occupational exposure

K. De Jong, J.M. Vonk, D.A. Van Der Plaat, C.C. Van Diemen, H. Kromhout, R. Vermeulen, C.M. Van Duijn, D.S. Postma, H.M. Boezen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: A striking proportion (25-45%) of chronic obstructive pulmonary disease (COPD) cases has never smoked. Yet, the biological pathways underlying non-smoking related COPD are still unknown. Genetic susceptibility to occupational exposures might play a key role. We therefore studied interactions between single nucleotide polymorphisms (SNPs) and occupational exposure to biological dust, mineral dust and gases/fumes on the level of FEV1 in never-smokers. Methods: Genome-wide SNP-by-occupational exposure interactions on the level of FEV1 were assessed in never-smokers from two independent general population-based cohorts, the LifeLines study (n=5070) and the VlagtweddeVlaardingen study (n=431). Effect estimates were meta-analyzed and significant SNPs selected based on a Bonferroni-corrected threshold of p
Original languageEnglish
JournalEuropean Respiratory Journal
Volume46
DOIs
Publication statusPublished - 1 Sept 2015

Keywords

  • interleukin 10
  • transcription factor
  • smoking
  • human
  • occupational exposure
  • European
  • society
  • gene
  • mineral dust
  • chronic obstructive lung disease
  • dust
  • single nucleotide polymorphism
  • exposure
  • genetic susceptibility
  • fume
  • population
  • genome
  • lung function

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