Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Saskia L Smits; Ed E Zijlstra; Jaap J van Hellemond; Claudia M E Schapendonk; Rogier Bodewes; Anita C Schürch; Bart L Haagmans; Albert D M E Osterhaus

doi:10.3201/eid1909.130404

Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Saskia L Smits
, Ed E Zijlstra
, Jaap J van Hellemond
, Claudia M E Schapendonk
, Rogier Bodewes
, Anita C Schürch
, Bart L Haagmans
, Albert D M E Osterhaus

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

Original language	English
Journal	Emerging Infectious Diseases
Volume	19
Issue number	9
DOIs	https://doi.org/10.3201/eid1909.130404
Publication status	Published - 2013

Keywords

Cerebrospinal Fluid
Circoviridae
Circoviridae Infections
Gene Order
Genes, Viral
Genome, Viral
Humans
Malawi
Metagenomics
Molecular Sequence Data
Phylogeny
Prevalence

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10.3201/eid1909.130404

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@article{fe6328932ac445ee8506babdbc8ec7ea,

title = "Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011",

abstract = "To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15\% and 10\% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.",

keywords = "Cerebrospinal Fluid, Circoviridae, Circoviridae Infections, Gene Order, Genes, Viral, Genome, Viral, Humans, Malawi, Metagenomics, Molecular Sequence Data, Phylogeny, Prevalence",

author = "Smits, \{Saskia L\} and Zijlstra, \{Ed E\} and \{van Hellemond\}, \{Jaap J\} and Schapendonk, \{Claudia M E\} and Rogier Bodewes and Sch{\"u}rch, \{Anita C\} and Haagmans, \{Bart L\} and Osterhaus, \{Albert D M E\}",

year = "2013",

doi = "10.3201/eid1909.130404",

language = "English",

volume = "19",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "9",

}

TY - JOUR

T1 - Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

AU - Smits, Saskia L

AU - Zijlstra, Ed E

AU - van Hellemond, Jaap J

AU - Schapendonk, Claudia M E

AU - Bodewes, Rogier

AU - Schürch, Anita C

AU - Haagmans, Bart L

AU - Osterhaus, Albert D M E

PY - 2013

Y1 - 2013

N2 - To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

AB - To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

KW - Cerebrospinal Fluid

KW - Circoviridae

KW - Circoviridae Infections

KW - Gene Order

KW - Genes, Viral

KW - Genome, Viral

KW - Humans

KW - Malawi

KW - Metagenomics

KW - Molecular Sequence Data

KW - Phylogeny

KW - Prevalence

U2 - 10.3201/eid1909.130404

DO - 10.3201/eid1909.130404

M3 - Article

C2 - 23968557

SN - 1080-6040

VL - 19

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 9

ER -

Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Abstract

Keywords

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