Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Saskia L Smits, Ed E Zijlstra, Jaap J van Hellemond, Claudia M E Schapendonk, Rogier Bodewes, Anita C Schürch, Bart L Haagmans, Albert D M E Osterhaus

Research output: Contribution to journalArticleAcademicpeer-review


To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

Original languageEnglish
JournalEmerging Infectious Diseases
Issue number9
Publication statusPublished - 2013


  • Cerebrospinal Fluid
  • Circoviridae
  • Circoviridae Infections
  • Gene Order
  • Genes, Viral
  • Genome, Viral
  • Humans
  • Malawi
  • Metagenomics
  • Molecular Sequence Data
  • Phylogeny
  • Prevalence


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