Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Saskia L Smits; Ed E Zijlstra; Jaap J van Hellemond; Claudia M E Schapendonk; Rogier Bodewes; Anita C Schürch; Bart L Haagmans; Albert D M E Osterhaus

doi:10.3201/eid1909.130404

Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Saskia L Smits, Ed E Zijlstra, Jaap J van Hellemond, Claudia M E Schapendonk, Rogier Bodewes, Anita C Schürch, Bart L Haagmans, Albert D M E Osterhaus

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

Original language	English
Journal	Emerging Infectious Diseases
Volume	19
Issue number	9
DOIs	https://doi.org/10.3201/eid1909.130404
Publication status	Published - 2013

Keywords

Cerebrospinal Fluid
Circoviridae
Circoviridae Infections
Gene Order
Genes, Viral
Genome, Viral
Humans
Malawi
Metagenomics
Molecular Sequence Data
Phylogeny
Prevalence

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10.3201/eid1909.130404

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@article{fe6328932ac445ee8506babdbc8ec7ea,

title = "Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011",

abstract = "To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.",

keywords = "Cerebrospinal Fluid, Circoviridae, Circoviridae Infections, Gene Order, Genes, Viral, Genome, Viral, Humans, Malawi, Metagenomics, Molecular Sequence Data, Phylogeny, Prevalence",

author = "Smits, {Saskia L} and Zijlstra, {Ed E} and {van Hellemond}, {Jaap J} and Schapendonk, {Claudia M E} and Rogier Bodewes and Sch{\"u}rch, {Anita C} and Haagmans, {Bart L} and Osterhaus, {Albert D M E}",

year = "2013",

doi = "10.3201/eid1909.130404",

language = "English",

volume = "19",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "9",

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TY - JOUR

T1 - Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

AU - Smits, Saskia L

AU - Zijlstra, Ed E

AU - van Hellemond, Jaap J

AU - Schapendonk, Claudia M E

AU - Bodewes, Rogier

AU - Schürch, Anita C

AU - Haagmans, Bart L

AU - Osterhaus, Albert D M E

PY - 2013

Y1 - 2013

N2 - To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

AB - To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.

KW - Cerebrospinal Fluid

KW - Circoviridae

KW - Circoviridae Infections

KW - Gene Order

KW - Genes, Viral

KW - Genome, Viral

KW - Humans

KW - Malawi

KW - Metagenomics

KW - Molecular Sequence Data

KW - Phylogeny

KW - Prevalence

U2 - 10.3201/eid1909.130404

DO - 10.3201/eid1909.130404

M3 - Article

C2 - 23968557

SN - 1080-6040

VL - 19

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 9

ER -

Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

Abstract

Keywords

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