Abstract
Novel alfa-aminophosphonic acids are synthesized reacting 1,3-oxazolidin-2-one derivatives with formaldehyde and phosphorus trichloride. Treatment of N-(phosphonomethyl)oxazolidinones with aqueous NaOH gave the expected alfa-aminophosphonic acids. The oxidation of (2-hydroxy-1,1-dimethylethylamino)methyl phosphonic acid in the presence of CdO and water resulted in N-phosphonomethyl-2-methyl-1-propanoic acid. Their structures were proved by means of IR, 1H, 13C and 31P NMR spectroscopy. The genotoxic, clastogenic, and antiproliferative effects of newly synthesizes original aminophosphonic acids were investigated for the first time.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 2190-2196 |
| Number of pages | 7 |
| Journal | Bioorganic & Medicinal Chemistry |
| Volume | 14 |
| Publication status | Published - 2006 |