Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

Natasja G. de Groot; Nel Otting; Giuseppe Maccari; James Robinson; John A. Hammond; Antoine Blancher; Bernard A.P. Lafont; Lisbeth A. Guethlein; Emily E. Wroblewski; Steven G.E. Marsh; Takashi Shiina; Lutz Walter; Linda Vigilant; Peter Parham; David H. O’Connor; Ronald E. Bontrop

doi:10.1007/s00251-019-01132-x

Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

Natasja G. de Groot^*, Nel Otting, Giuseppe Maccari, James Robinson, John A. Hammond, Antoine Blancher, Bernard A.P. Lafont, Lisbeth A. Guethlein, Emily E. Wroblewski, Steven G.E. Marsh, Takashi Shiina, Lutz Walter, Linda Vigilant, Peter Parham, David H. O’Connor, Ronald E. Bontrop

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database.

Original language	English
Pages (from-to)	25–36
Journal	Immunogenetics
Volume	72
DOIs	https://doi.org/10.1007/s00251-019-01132-x
Publication status	Published - 17 Oct 2019

Funding

The authors would like to thank R. Wiseman and J. Caskey for their feedback on the manuscript, D. Devine for editing the manuscript, and F. van Hassel for the artwork. This study was supported in part by NIH/NIAID contract number HHSN272201600007C. GM and JAH are supported by the funding from the UKRI-BBSCR awards BB/M011488/1, BBS/E/I/00001710, BBS/E/I/00007030, and BBS/E/I/00007038. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Keywords

Database
IPD
MHC
NHP
Nomenclature

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Groot2020_Article_NomenclatureReport2019MajorHisFinal published version, 2.85 MBLicence: Taverne

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de Groot, N. G., Otting, N., Maccari, G., Robinson, J., Hammond, J. A., Blancher, A., Lafont, B. A. P., Guethlein, L. A., Wroblewski, E. E., Marsh, S. G. E., Shiina, T., Walter, L., Vigilant, L., Parham, P., O’Connor, D. H., & Bontrop, R. E. (2019). Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species. Immunogenetics, 72, 25–36. https://doi.org/10.1007/s00251-019-01132-x

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title = "Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species",

abstract = "The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database.",

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author = "\{de Groot\}, \{Natasja G.\} and Nel Otting and Giuseppe Maccari and James Robinson and Hammond, \{John A.\} and Antoine Blancher and Lafont, \{Bernard A.P.\} and Guethlein, \{Lisbeth A.\} and Wroblewski, \{Emily E.\} and Marsh, \{Steven G.E.\} and Takashi Shiina and Lutz Walter and Linda Vigilant and Peter Parham and O{\textquoteright}Connor, \{David H.\} and Bontrop, \{Ronald E.\}",

year = "2019",

month = oct,

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doi = "10.1007/s00251-019-01132-x",

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de Groot, NG, Otting, N, Maccari, G, Robinson, J, Hammond, JA, Blancher, A, Lafont, BAP, Guethlein, LA, Wroblewski, EE, Marsh, SGE, Shiina, T, Walter, L, Vigilant, L, Parham, P, O’Connor, DH & Bontrop, RE 2019, 'Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species', Immunogenetics, vol. 72, pp. 25–36. https://doi.org/10.1007/s00251-019-01132-x

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AU - de Groot, Natasja G.

AU - Otting, Nel

AU - Maccari, Giuseppe

AU - Robinson, James

AU - Hammond, John A.

AU - Blancher, Antoine

AU - Lafont, Bernard A.P.

AU - Guethlein, Lisbeth A.

AU - Wroblewski, Emily E.

AU - Marsh, Steven G.E.

AU - Shiina, Takashi

AU - Walter, Lutz

AU - Vigilant, Linda

AU - Parham, Peter

AU - O’Connor, David H.

AU - Bontrop, Ronald E.

PY - 2019/10/17

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AB - The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database.

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JO - Immunogenetics

JF - Immunogenetics

ER -

Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

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