No detectable beneficial systemic immunomodulatory effects of a specific synbiotic mixture in infants with atopic dermatitis.

L.B. van der Aa, R. Lutter, H.S.A. Heymans, B.S. Smids, G.H. Dekker, W.M.C van Aalderen, JH Sillevis Smitt, L.M.J. Knippels, J. Garssen, A.J. Nauta, A.B. Sprikkelman

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: In a murine model of allergic inflammation, Bifidobacterium breve M-16V has been shown to reduce IL-4 and IgE by inducing IL-10 and IFN-gamma. However, it remains unknown whether this strain has the same effect in humans with allergic disease. OBJECTIVE: To determine the effects of Bifidobacterium breve M-16V combined with a prebiotic oligosaccharide mixture (synbiotic) on atopic markers, ex vivo cytokine production by peripheral blood mononuclear cells (PBMCs) and circulating regulatory T cell percentage in infants with atopic dermatitis. METHODS: In a double-blind, placebo-controlled multi-centre trial, 90 infants with atopic dermatitis, age
Original languageUndefined/Unknown
Pages (from-to)531-9
Number of pages9
JournalClinical and Experimental Allergy
Issue number4
Publication statusPublished - 2012

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