New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

N.A. Fineberg; S.R. Chamberlain; A.E. Goudriaan; D.J. Stein; L.J.M.J. Vanderschuren; C.M. Gillan; S. Shekar; P. Gorwood; V. Voon; S. Morein-Zamir; D.A.J.P. Denys; B.J. Sahakian; F.G. Moeller; T.W. Robbins; M.N. Potenza

doi:10.1017/S1092852913000801

New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

N.A. Fineberg, S.R. Chamberlain, A.E. Goudriaan, D.J. Stein, L.J.M.J. Vanderschuren, C.M. Gillan, S. Shekar, P. Gorwood, V. Voon, S. Morein-Zamir, D.A.J.P. Denys, B.J. Sahakian, F.G. Moeller, T.W. Robbins, M.N. Potenza

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

Original language	English
Pages (from-to)	69-89
Number of pages	21
Journal	CNS Spectrums
Volume	19
Issue number	1
DOIs	https://doi.org/10.1017/S1092852913000801
Publication status	Published - 2014

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http://www.ncbi.nlm.nih.gov/pubmed/24512640

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Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J. M. J., Gillan, C. M., Shekar, S., Gorwood, P., Voon, V., Morein-Zamir, S., Denys, D. A. J. P., Sahakian, B. J., Moeller, F. G., Robbins, T. W., & Potenza, M. N. (2014). New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectrums, 19(1), 69-89. https://doi.org/10.1017/S1092852913000801

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abstract = "Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research. ",

author = "N.A. Fineberg and S.R. Chamberlain and A.E. Goudriaan and D.J. Stein and L.J.M.J. Vanderschuren and C.M. Gillan and S. Shekar and P. Gorwood and V. Voon and S. Morein-Zamir and D.A.J.P. Denys and B.J. Sahakian and F.G. Moeller and T.W. Robbins and M.N. Potenza",

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doi = "10.1017/S1092852913000801",

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Fineberg, NA, Chamberlain, SR, Goudriaan, AE, Stein, DJ, Vanderschuren, LJMJ, Gillan, CM, Shekar, S, Gorwood, P, Voon, V, Morein-Zamir, S, Denys, DAJP, Sahakian, BJ, Moeller, FG, Robbins, TW & Potenza, MN 2014, 'New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity', CNS Spectrums, vol. 19, no. 1, pp. 69-89. https://doi.org/10.1017/S1092852913000801

TY - JOUR

T1 - New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

AU - Fineberg, N.A.

AU - Chamberlain, S.R.

AU - Goudriaan, A.E.

AU - Stein, D.J.

AU - Vanderschuren, L.J.M.J.

AU - Gillan, C.M.

AU - Shekar, S.

AU - Gorwood, P.

AU - Voon, V.

AU - Morein-Zamir, S.

AU - Denys, D.A.J.P.

AU - Sahakian, B.J.

AU - Moeller, F.G.

AU - Robbins, T.W.

AU - Potenza, M.N.

PY - 2014

Y1 - 2014

N2 - Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

AB - Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

U2 - 10.1017/S1092852913000801

DO - 10.1017/S1092852913000801

M3 - Article

SN - 1092-8529

VL - 19

SP - 69

EP - 89

JO - CNS Spectrums

JF - CNS Spectrums

IS - 1

ER -

New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

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