New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by regulatory T cells

F. Hauet-Broere, W.W.J. Unger, L.A. Van Berkel, J. Garssen, M.A. Hoijer, G. Kraal, Janneke N. Samsom

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Although as pretreatment oral tolerance is a potent means to achieve systemic suppression, its application in ongoing disease is controversial. Here we propose that availability of naive T cells may critically determine whether immunological tolerance is achieved during ongoing antigenic reactivity. Infusion of naive antigen-specific T cells into mice directly prior to eliciting a secondary Th2 response induces these naive cells to actively engage in the antigenic response despite presence of established memory. Naive antigen-specific T-cells divided faster, produced more interleukin (IL)-2, IL-4 and IL-5 and enhanced immunoglobulin E (IgE) release during a secondary T h2 response, compared with naive T cells that were infused prior to a primary response. Despite such contribution by new cohorts of naive T cells co-infusion of mucosal Tr together with naive T cells could suppress enhanced IgE release during a secondary Th2 response. We conclude that naive T cells contribute to a secondary Th2 response and although they can still be suppressed in the presence of sufficient numbers of mucosal Tr, they may interfere with potential therapeutic application of mucosal tolerance. Copyright © Blackwell Munksgaard 2005.
Original languageEnglish
Pages (from-to)1530-1536
Number of pages7
JournalAllergy
Volume60
Issue number12
DOIs
Publication statusPublished - 1 Dec 2005

Keywords

  • Farmacie/Biofarmaceutische wetenschappen (FARM)
  • Farmacie(FARM)
  • Diergeneeskunde (DGNK)
  • Biomedische technologie en medicijnen
  • Immunology
  • Pharmacology
  • Overig medisch onderzoek

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