Abstract
Although as pretreatment oral tolerance is a potent means to achieve systemic suppression, its application in ongoing disease is controversial. Here we propose that availability of naive T cells may critically determine whether immunological tolerance is achieved during ongoing antigenic reactivity. Infusion of naive antigen-specific T cells into mice directly prior to eliciting a secondary Th2 response induces these naive cells to actively engage in the antigenic response despite presence of established memory. Naive antigen-specific T-cells divided faster, produced more interleukin (IL)-2, IL-4 and IL-5 and enhanced immunoglobulin E (IgE) release during a secondary T h2 response, compared with naive T cells that were infused prior to a primary response. Despite such contribution by new cohorts of naive T cells co-infusion of mucosal Tr together with naive T cells could suppress enhanced IgE release during a secondary Th2 response. We conclude that naive T cells contribute to a secondary Th2 response and although they can still be suppressed in the presence of sufficient numbers of mucosal Tr, they may interfere with potential therapeutic application of mucosal tolerance. Copyright © Blackwell Munksgaard 2005.
Original language | English |
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Pages (from-to) | 1530-1536 |
Number of pages | 7 |
Journal | Allergy |
Volume | 60 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2005 |
Keywords
- Farmacie/Biofarmaceutische wetenschappen (FARM)
- Farmacie(FARM)
- Diergeneeskunde (DGNK)
- Biomedische technologie en medicijnen
- Immunology
- Pharmacology
- Overig medisch onderzoek