Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model

A.M. Pinto; M. Luís; R. Geenen; F. Palavra; M.A. Lumley; J.N. Ablin; K. Amris; J. Branco; D. Buskila; J. Castelhano; M. Castelo-Branco; L.J. Crofford; M.-A. Fitzcharles; W. Häuser; E. Kosek; M. López-Solà; P. Mease; T.R. Marques; J.W.G. Jacobs; P. Castilho; J.A.P. da Silva

doi:10.1016/j.neubiorev.2023.105235

Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model

A.M. Pinto, M. Luís, R. Geenen, F. Palavra, M.A. Lumley, J.N. Ablin, K. Amris, J. Branco, D. Buskila, J. Castelhano, M. Castelo-Branco, L.J. Crofford, M.-A. Fitzcharles, W. Häuser, E. Kosek, M. López-Solà, P. Mease, T.R. Marques, J.W.G. Jacobs, P. CastilhoJ.A.P. da Silva

Research output: Contribution to journal › Review article › peer-review

Abstract

Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.

Original language	English
Article number	105235
Pages (from-to)	1-23
Number of pages	23
Journal	Neuroscience and Biobehavioral Reviews
Volume	151
Early online date	18 May 2023
DOIs	https://doi.org/10.1016/j.neubiorev.2023.105235
Publication status	Published - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Funding

AMP is the holder of a PhD Grant (SFRH/BD/145954/2019), sponsored by the Portuguese Foundation for Science and Technology (FCT), the Human Capital Operational Programme (POCH), and the European Union (EU), and was financially supported (through stipend) for part of this work by the Coimbra Rheumatology Association ( ARCo ) and the Portuguese Society of Rheumatology ( SPR ).

Funders	Funder number
Human Capital Operational Programme
Portuguese Society of Rheumatology
European Commission
Fundação para a Ciência e a Tecnologia

Keywords

Dynamic interplay
Fibromyalgia
Integrative
Neurophysiological abnormalities
Psychosocial processes

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10.1016/j.neubiorev.2023.105235

1-s2.0-S014976342300204X-mainFinal published version, 1.5 MBLicence: Taverne

Cite this

Pinto, A. M., Luís, M., Geenen, R., Palavra, F., Lumley, M. A., Ablin, J. N., Amris, K., Branco, J., Buskila, D., Castelhano, J., Castelo-Branco, M., Crofford, L. J., Fitzcharles, M.-A., Häuser, W., Kosek, E., López-Solà, M., Mease, P., Marques, T. R., Jacobs, J. W. G., ... da Silva, J. A. P. (2023). Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model. Neuroscience and Biobehavioral Reviews, 151, 1-23. Article 105235. https://doi.org/10.1016/j.neubiorev.2023.105235

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title = "Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model",

abstract = "Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.",

keywords = "Dynamic interplay, Fibromyalgia, Integrative, Neurophysiological abnormalities, Psychosocial processes",

author = "A.M. Pinto and M. Lu{\'i}s and R. Geenen and F. Palavra and M.A. Lumley and J.N. Ablin and K. Amris and J. Branco and D. Buskila and J. Castelhano and M. Castelo-Branco and L.J. Crofford and M.-A. Fitzcharles and W. H{\"a}user and E. Kosek and M. L{\'o}pez-Sol{\`a} and P. Mease and T.R. Marques and J.W.G. Jacobs and P. Castilho and {da Silva}, J.A.P.",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = aug,

doi = "10.1016/j.neubiorev.2023.105235",

language = "English",

volume = "151",

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Pinto, AM, Luís, M, Geenen, R, Palavra, F, Lumley, MA, Ablin, JN, Amris, K, Branco, J, Buskila, D, Castelhano, J, Castelo-Branco, M, Crofford, LJ, Fitzcharles, M-A, Häuser, W, Kosek, E, López-Solà, M, Mease, P, Marques, TR, Jacobs, JWG, Castilho, P & da Silva, JAP 2023, 'Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model', Neuroscience and Biobehavioral Reviews, vol. 151, 105235, pp. 1-23. https://doi.org/10.1016/j.neubiorev.2023.105235

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T2 - A comprehensive review and call for an integrative model

AU - Pinto, A.M.

AU - Luís, M.

AU - Geenen, R.

AU - Palavra, F.

AU - Lumley, M.A.

AU - Ablin, J.N.

AU - Amris, K.

AU - Branco, J.

AU - Buskila, D.

AU - Castelhano, J.

AU - Castelo-Branco, M.

AU - Crofford, L.J.

AU - Fitzcharles, M.-A.

AU - Häuser, W.

AU - Kosek, E.

AU - López-Solà, M.

AU - Mease, P.

AU - Marques, T.R.

AU - Jacobs, J.W.G.

AU - Castilho, P.

AU - da Silva, J.A.P.

PY - 2023/8

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N2 - Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.

AB - Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.

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KW - Neurophysiological abnormalities

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SN - 0149-7634

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JO - Neuroscience and Biobehavioral Reviews

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M1 - 105235

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Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model

Abstract

Bibliographical note

Funding

Keywords

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