Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

F. Renner; N. Siep; A. Arntz; V. van de Ven; F.P.M.L. Peeters; C.W.E.M. Quaedflieg; M.J.H. Huibers

doi:10.1016/j.jad.2016.10.022

Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

F. Renner^*, N. Siep, A. Arntz, V. van de Ven, F.P.M.L. Peeters, C.W.E.M. Quaedflieg, M.J.H. Huibers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background

The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).

Methods

Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.

Results

Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.

Limitations

Limitations of this study include the relatively small sample size and lack of a clinical control group.

Conclusions

These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

Original language	English
Pages (from-to)	590-596
Journal	Journal of Affective Disorders
Volume	208
DOIs	https://doi.org/10.1016/j.jad.2016.10.022
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Funding Information:
This work was support by Maastricht University and by the Academic Community Mental Health Centre (RIAGG) Maastricht.

Publisher Copyright:
© 2016 Elsevier B.V.

Funding

This work was support by Maastricht University and by the Academic Community Mental Health Centre (RIAGG) Maastricht.

Keywords

Chronic depression
Default mode network
Mood-induction
Posterior cingulate cortex
Resting state fMRI

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jad.2016.10.022

Cite this

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title = "Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression",

abstract = "Background The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD). Methods Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements. Results Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls. Limitations Limitations of this study include the relatively small sample size and lack of a clinical control group. Conclusions These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.",

keywords = "Chronic depression, Default mode network, Mood-induction, Posterior cingulate cortex, Resting state fMRI",

author = "F. Renner and N. Siep and A. Arntz and {van de Ven}, V. and F.P.M.L. Peeters and C.W.E.M. Quaedflieg and M.J.H. Huibers",

note = "Funding Information: This work was support by Maastricht University and by the Academic Community Mental Health Centre (RIAGG) Maastricht. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

year = "2017",

doi = "10.1016/j.jad.2016.10.022",

language = "English",

volume = "208",

pages = "590--596",

journal = "Journal of Affective Disorders",

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T1 - Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

AU - Renner, F.

AU - Siep, N.

AU - Arntz, A.

AU - van de Ven, V.

AU - Peeters, F.P.M.L.

AU - Quaedflieg, C.W.E.M.

AU - Huibers, M.J.H.

PY - 2017

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N2 - Background The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD). Methods Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements. Results Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls. Limitations Limitations of this study include the relatively small sample size and lack of a clinical control group. Conclusions These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

AB - Background The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD). Methods Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements. Results Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls. Limitations Limitations of this study include the relatively small sample size and lack of a clinical control group. Conclusions These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

KW - Chronic depression

KW - Default mode network

KW - Mood-induction

KW - Posterior cingulate cortex

KW - Resting state fMRI

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ER -

Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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