N-glycosylation and glycoengineering in the mushroom-forming fungus Schizophyllum commune

E. Berends

N-glycosylation and glycoengineering in the mushroom-forming fungus Schizophyllum commune

E. Berends

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. As a consequence there is a need for cost-effective production platforms that display correct and homogeneous N-glycosylation. In this thesis, we investigate the use of mushroom forming basidiomycetes for the production of N-glycosylated therapeutic proteins

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Utrecht University
Supervisors/Advisors	Bosch, H.J., Primary supervisor Wösten, Han, Supervisor Lugones, Luis, Co-supervisor
Award date	21 Jan 2013
Publisher	Utrecht University
Print ISBNs	978-90-393-5960-0
Publication status	Published - 21 Jan 2013

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AB - The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. As a consequence there is a need for cost-effective production platforms that display correct and homogeneous N-glycosylation. In this thesis, we investigate the use of mushroom forming basidiomycetes for the production of N-glycosylated therapeutic proteins

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N-glycosylation and glycoengineering in the mushroom-forming fungus Schizophyllum commune

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