Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]

Rick Rink; Jeffrey H. Lutje Spelberg; Roland J. Pieters; Jaap Kingma; Marco Nardini; Richard M. Kellogg; Bauke W. Dijkstra; Dick B. Janssen

doi:10.1021/ja990501o

Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]

Rick Rink
, Jeffrey H. Lutje Spelberg
, Roland J. Pieters
, Jaap Kingma
, Marco Nardini
, Richard M. Kellogg
, Bauke W. Dijkstra
, Dick B. Janssen

Research output: Contribution to journal › Letter › Academic › peer-review

Original language	English
Pages (from-to)	7417-7418
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	121
Issue number	32
DOIs	https://doi.org/10.1021/ja990501o
Publication status	Published - 18 Aug 1999
Externally published	Yes

Keywords

epoxide
epoxide hydrolase
mutant protein
tyrosine
catalysis
enantiomer
enzyme active site
enzyme kinetics
letter
nonhuman
Rhizobium
stereochemistry

Access to Document

10.1021/ja990501o

Cite this

Rink, R., Lutje Spelberg, J. H., Pieters, R. J., Kingma, J., Nardini, M., Kellogg, R. M., Dijkstra, B. W., & Janssen, D. B. (1999). Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]. Journal of the American Chemical Society, 121(32), 7417-7418. https://doi.org/10.1021/ja990501o

@article{12c2f68dc2754cf6a67b8c2097847b74,

title = "Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]",

keywords = "epoxide, epoxide hydrolase, mutant protein, tyrosine, catalysis, enantiomer, enzyme active site, enzyme kinetics, letter, nonhuman, Rhizobium, stereochemistry",

author = "Rick Rink and \{Lutje Spelberg\}, \{Jeffrey H.\} and Pieters, \{Roland J.\} and Jaap Kingma and Marco Nardini and Kellogg, \{Richard M.\} and Dijkstra, \{Bauke W.\} and Janssen, \{Dick B.\}",

year = "1999",

month = aug,

day = "18",

doi = "10.1021/ja990501o",

language = "English",

volume = "121",

pages = "7417--7418",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "32",

}

Rink, R, Lutje Spelberg, JH, Pieters, RJ, Kingma, J, Nardini, M, Kellogg, RM, Dijkstra, BW & Janssen, DB 1999, 'Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]', Journal of the American Chemical Society, vol. 121, no. 32, pp. 7417-7418. https://doi.org/10.1021/ja990501o

Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]. / Rink, Rick; Lutje Spelberg, Jeffrey H.; Pieters, Roland J. et al.
In: Journal of the American Chemical Society, Vol. 121, No. 32, 18.08.1999, p. 7417-7418.

Research output: Contribution to journal › Letter › Academic › peer-review

TY - JOUR

T1 - Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity [7]

AU - Rink, Rick

AU - Lutje Spelberg, Jeffrey H.

AU - Pieters, Roland J.

AU - Kingma, Jaap

AU - Nardini, Marco

AU - Kellogg, Richard M.

AU - Dijkstra, Bauke W.

AU - Janssen, Dick B.

PY - 1999/8/18

Y1 - 1999/8/18

KW - epoxide

KW - epoxide hydrolase

KW - mutant protein

KW - tyrosine

KW - catalysis

KW - enantiomer

KW - enzyme active site

KW - enzyme kinetics

KW - letter

KW - nonhuman

KW - Rhizobium

KW - stereochemistry

U2 - 10.1021/ja990501o

DO - 10.1021/ja990501o

M3 - Letter

SN - 0002-7863

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

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