Multiscale heterogeneity in filamentous microbes

Boris Zacchetti; Han A B Wösten; Dennis Claessen

doi:10.1016/j.biotechadv.2018.10.002

Multiscale heterogeneity in filamentous microbes

Boris Zacchetti, Han A B Wösten, Dennis Claessen

Microbial Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333, BE, Leiden, The Netherlands.
Microbial Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333, BE, Leiden, The Netherlands.. Electronic address: [email protected].

Research output: Contribution to journal › Review article › peer-review

Abstract

Microbial cells within clonal populations can display different morphologies or carry out different tasks. This heterogeneity is beneficial at the population level and allows microbes to spread risk or separate incompatible activities. Heterogeneity is also evident in filamentous bacteria and fungi, which form mycelial networks consisting of interconnected hyphae. Here, heterogeneity is observed between clonal mycelial particles, between different zones of colonies, between adjacent hyphae and even between adjacent compartments of individual hyphae. In this review, we compare this multiscale heterogeneity in filamentous bacteria and fungi and discuss the underlying mechanisms. These mechanisms might provide targets to improve the exploitability of these organisms as cell factories in the biotech sector.

Original language	English
Pages (from-to)	2138-2149
Number of pages	12
Journal	Biotechnology Advances
Volume	36
Issue number	8
DOIs	https://doi.org/10.1016/j.biotechadv.2018.10.002
Publication status	Published - Dec 2018

Keywords

Heterogeneity
Fungi
Actinomycetes
Biotechnology
Multicellularity

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10.1016/j.biotechadv.2018.10.002

1-s2.0-S0734975018301654-mainFinal published version, 1.58 MBLicence: Taverne

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title = "Multiscale heterogeneity in filamentous microbes",

abstract = "Microbial cells within clonal populations can display different morphologies or carry out different tasks. This heterogeneity is beneficial at the population level and allows microbes to spread risk or separate incompatible activities. Heterogeneity is also evident in filamentous bacteria and fungi, which form mycelial networks consisting of interconnected hyphae. Here, heterogeneity is observed between clonal mycelial particles, between different zones of colonies, between adjacent hyphae and even between adjacent compartments of individual hyphae. In this review, we compare this multiscale heterogeneity in filamentous bacteria and fungi and discuss the underlying mechanisms. These mechanisms might provide targets to improve the exploitability of these organisms as cell factories in the biotech sector.",

keywords = "Heterogeneity, Fungi, Actinomycetes, Biotechnology, Multicellularity",

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year = "2018",

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doi = "10.1016/j.biotechadv.2018.10.002",

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T1 - Multiscale heterogeneity in filamentous microbes

AU - Zacchetti, Boris

AU - Wösten, Han A B

AU - Claessen, Dennis

PY - 2018/12

Y1 - 2018/12

N2 - Microbial cells within clonal populations can display different morphologies or carry out different tasks. This heterogeneity is beneficial at the population level and allows microbes to spread risk or separate incompatible activities. Heterogeneity is also evident in filamentous bacteria and fungi, which form mycelial networks consisting of interconnected hyphae. Here, heterogeneity is observed between clonal mycelial particles, between different zones of colonies, between adjacent hyphae and even between adjacent compartments of individual hyphae. In this review, we compare this multiscale heterogeneity in filamentous bacteria and fungi and discuss the underlying mechanisms. These mechanisms might provide targets to improve the exploitability of these organisms as cell factories in the biotech sector.

AB - Microbial cells within clonal populations can display different morphologies or carry out different tasks. This heterogeneity is beneficial at the population level and allows microbes to spread risk or separate incompatible activities. Heterogeneity is also evident in filamentous bacteria and fungi, which form mycelial networks consisting of interconnected hyphae. Here, heterogeneity is observed between clonal mycelial particles, between different zones of colonies, between adjacent hyphae and even between adjacent compartments of individual hyphae. In this review, we compare this multiscale heterogeneity in filamentous bacteria and fungi and discuss the underlying mechanisms. These mechanisms might provide targets to improve the exploitability of these organisms as cell factories in the biotech sector.

KW - Heterogeneity

KW - Fungi

KW - Actinomycetes

KW - Biotechnology

KW - Multicellularity

U2 - 10.1016/j.biotechadv.2018.10.002

DO - 10.1016/j.biotechadv.2018.10.002

M3 - Review article

C2 - 30292788

SN - 0734-9750

VL - 36

SP - 2138

EP - 2149

JO - Biotechnology Advances

JF - Biotechnology Advances

IS - 8

ER -

Multiscale heterogeneity in filamentous microbes

Abstract

Keywords

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