MRI evaluation of the antitumor activity of paramagnetic liposomes loaded with prednisolone phosphate.

E. Cittadino; M. Ferraretto; E. Torres; A. Maiocchi; B.J. Crielaard; T. Lammers; G. Storm; S. Aime; E. Terreno

MRI evaluation of the antitumor activity of paramagnetic liposomes loaded with prednisolone phosphate.

E. Cittadino, M. Ferraretto, E. Torres, A. Maiocchi, B.J. Crielaard, T. Lammers, G. Storm, S. Aime, E. Terreno

Pharmaceutics

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The design of long circulating liposomes co-loaded with the glucocorticoid prednisolone phosphate (PLP) and the amphiphilic paramagnetic contrast agent Gd-DOTAMA(C(18))(2) allowed the MRI-guided in vivo visualization of the delivery and biodistribution of PLP, as well as the monitoring of drug efficacy. The performance of this theranostic probe was investigated in a mouse model bearing a melanoma B16 syngeneic tumor. The release kinetics of the drug were evaluated in vitro where it displayed a peculiar behavior characterized by a fast process (completed in few hours) involving only a small portion (

Original language	Undefined/Unknown
Pages (from-to)	436-41
Number of pages	6
Journal	European Journal of Pharmaceutical Sciences
Volume	45
Issue number	4
Publication status	Published - 2012

Cite this

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title = "MRI evaluation of the antitumor activity of paramagnetic liposomes loaded with prednisolone phosphate.",

abstract = "The design of long circulating liposomes co-loaded with the glucocorticoid prednisolone phosphate (PLP) and the amphiphilic paramagnetic contrast agent Gd-DOTAMA(C(18))(2) allowed the MRI-guided in vivo visualization of the delivery and biodistribution of PLP, as well as the monitoring of drug efficacy. The performance of this theranostic probe was investigated in a mouse model bearing a melanoma B16 syngeneic tumor. The release kinetics of the drug were evaluated in vitro where it displayed a peculiar behavior characterized by a fast process (completed in few hours) involving only a small portion (",

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year = "2012",

language = "Undefined/Unknown",

volume = "45",

pages = "436--41",

journal = "European Journal of Pharmaceutical Sciences",

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TY - JOUR

T1 - MRI evaluation of the antitumor activity of paramagnetic liposomes loaded with prednisolone phosphate.

AU - Cittadino, E.

AU - Ferraretto, M.

AU - Torres, E.

AU - Maiocchi, A.

AU - Crielaard, B.J.

AU - Lammers, T.

AU - Storm, G.

AU - Aime, S.

AU - Terreno, E.

PY - 2012

Y1 - 2012

N2 - The design of long circulating liposomes co-loaded with the glucocorticoid prednisolone phosphate (PLP) and the amphiphilic paramagnetic contrast agent Gd-DOTAMA(C(18))(2) allowed the MRI-guided in vivo visualization of the delivery and biodistribution of PLP, as well as the monitoring of drug efficacy. The performance of this theranostic probe was investigated in a mouse model bearing a melanoma B16 syngeneic tumor. The release kinetics of the drug were evaluated in vitro where it displayed a peculiar behavior characterized by a fast process (completed in few hours) involving only a small portion (

AB - The design of long circulating liposomes co-loaded with the glucocorticoid prednisolone phosphate (PLP) and the amphiphilic paramagnetic contrast agent Gd-DOTAMA(C(18))(2) allowed the MRI-guided in vivo visualization of the delivery and biodistribution of PLP, as well as the monitoring of drug efficacy. The performance of this theranostic probe was investigated in a mouse model bearing a melanoma B16 syngeneic tumor. The release kinetics of the drug were evaluated in vitro where it displayed a peculiar behavior characterized by a fast process (completed in few hours) involving only a small portion (

M3 - Article

SN - 0928-0987

VL - 45

SP - 436

EP - 441

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 4

ER -