Molecular Pathways Governing the Termination of Liver Regeneration

Lianne R. de Haan; Rowan F. van Golen; Michal Heger

doi:10.1124/pharmrev.123.000955

Molecular Pathways Governing the Termination of Liver Regeneration

Lianne R. de Haan
, Rowan F. van Golen
, Michal Heger

Jiaxing University
Medical Center Of Alkmaar
Leiden University - Excl LUMC

Research output: Contribution to journal › Review article › peer-review

Abstract

The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called “hepatostat.” The initiation and growth phases have been the subject ofmany studies. Themolecular pathways that govern the termination phase, however, remain to be fully elucidated.

Original language	English
Pages (from-to)	500-558
Number of pages	59
Journal	Pharmacological Reviews
Volume	76
Issue number	3
DOIs	https://doi.org/10.1124/pharmrev.123.000955
Publication status	Published - May 2024

Bibliographical note

Publisher Copyright:
© 2024, American Society for Pharmacology and Experimental Therapy (ASPET). All rights reserved.

Funding

Address correspondence to: Michal Heger, Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, 118 Jiahang Rd, Nanhu District, 314001 Jiaxing, Zhejiang, P. R. China. E-mail: michal. [email protected]; or Michal Heger, Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. E-mail: [email protected] This work was supported by grants from the Dutch Cancer Foundation [KWF project # 10666], a Zhejiang Provincial Foreign Expert Program Grant, Zhejiang Provincial Key Natural Science Foundation of China [#Z20H160031], and a grant for the establishment of the Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics (to M.H.). The work comprises a chapter in the doctoral dissertation of L.R.d.H., entitled \u201CThe role of bile acids in liver regeneration,\u201D which was successfully defended on September 14, 2023. No author has an actual or perceived conflict of interest with the contents of this article. dx.doi.org/10.1124/pharmrev.123.000955.

Funders	Funder number
Cancer Couch Foundation
Zhejiang Provincial Key Natural Science Foundation of China
Zhejiang Provincial Foreign Expert Program
KWF Kankerbestrijding	10666

Keywords

Activated-receptor-gamma
Ccaat/enhancer-binding-protein
Glycogen-synthase kinase-3
Growth-factor-beta
Hsp90 inhibitor auy922
I dose-escalation
Portal-vein ligation
Retaspimycin hydrochloride ipi-504
Shock-protein 90
Tumor-necrosis-factor

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10.1124/pharmrev.123.000955

500.fullFinal published version, 3.51 MBLicence: Taverne

Cite this

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title = "Molecular Pathways Governing the Termination of Liver Regeneration",

abstract = "The liver has the unique capacity to regenerate, and up to 70\% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called {\textquotedblleft}hepatostat.{\textquotedblright} The initiation and growth phases have been the subject ofmany studies. Themolecular pathways that govern the termination phase, however, remain to be fully elucidated.",

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KW - Tumor-necrosis-factor

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Molecular Pathways Governing the Termination of Liver Regeneration

Abstract

Bibliographical note

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Keywords

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