Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

D. Serruto; R. Rappuoli; M. Scarselli; P. Gros; J.A.G. van Strijp

doi:10.1038/nrmicro2366

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

D. Serruto, R. Rappuoli, M. Scarselli, P. Gros, J.A.G. van Strijp

Sub Crystal and Structural Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.

Original language	English
Pages (from-to)	393-399
Number of pages	7
Journal	Nature Reviews. Microbiology
Volume	8
DOIs	https://doi.org/10.1038/nrmicro2366
Publication status	Published - 2010

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title = "Molecular mechanisms of complement evasion: learning from staphylococci and meningococci",

abstract = "The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.",

author = "D. Serruto and R. Rappuoli and M. Scarselli and P. Gros and {van Strijp}, J.A.G.",

year = "2010",

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AU - Gros, P.

AU - van Strijp, J.A.G.

PY - 2010

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N2 - The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.

AB - The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.

U2 - 10.1038/nrmicro2366

DO - 10.1038/nrmicro2366

M3 - Article

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VL - 8

SP - 393

EP - 399

JO - Nature Reviews. Microbiology

JF - Nature Reviews. Microbiology

ER -

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

Abstract

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