TY - CHAP
T1 - Molecular mechanisms of Campylobacter infection
AU - van Putten, J.P.M.
AU - van Alphen, L.
AU - Wosten, M.M.S.M.
AU - de Zoete, M.R.
PY - 2009
Y1 - 2009
N2 - Campylobacter jejuni is the principal bacterial foodborne pathogen. A major challenge still is to identify the virulence strategies exploited by C. jejuni. Recent genomics, proteomics, and metabolomics approaches indicate that C. jejuni displays extensive inter- and intrastrain variation. The diverse behavior enables bacterial adaptation to different environmental conditions and directs interactions with the gut mucosa. Here, we report recent progress in understanding the molecular mechanisms and functional consequences of the phenotype diversity. The results suggest that C. jejuni actively penetrates the intestinal mucus layer, secretes proteins mainly via its flagellar apparatus, is engulfed by intestinal cells, and can disrupt the integrity of the epithelial lining. C. jejuni stimulates the proinflammatory pathway and the production of a large repertoire of cytokines, chemokines, and innate effector molecules. Novel experimental infection models suggest that the activation of the innate immune response is important for the development of intestinal pathology.
AB - Campylobacter jejuni is the principal bacterial foodborne pathogen. A major challenge still is to identify the virulence strategies exploited by C. jejuni. Recent genomics, proteomics, and metabolomics approaches indicate that C. jejuni displays extensive inter- and intrastrain variation. The diverse behavior enables bacterial adaptation to different environmental conditions and directs interactions with the gut mucosa. Here, we report recent progress in understanding the molecular mechanisms and functional consequences of the phenotype diversity. The results suggest that C. jejuni actively penetrates the intestinal mucus layer, secretes proteins mainly via its flagellar apparatus, is engulfed by intestinal cells, and can disrupt the integrity of the epithelial lining. C. jejuni stimulates the proinflammatory pathway and the production of a large repertoire of cytokines, chemokines, and innate effector molecules. Novel experimental infection models suggest that the activation of the innate immune response is important for the development of intestinal pathology.
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-75649130825&partnerID=40&md5=373db3ce000b5f24c6e995cc80c7ec95
U2 - 10.1007/978-3-642-01846-6_7
DO - 10.1007/978-3-642-01846-6_7
M3 - Chapter
T3 - Current Topics in Microbiology and Immunology
SP - 197
EP - 229
BT - Molecular Mechanisms of Bacterial Infection via the Gut
PB - Springer
ER -