Modeling motor neuron disease: the matter of time

Manda Arbab, S.E. Baars, Niels Geijsen*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Stem cell technologies have created new opportunities
    to generate unlimited numbers of human neurons in the
    lab and study neurodegenerative disorders such as
    amyotrophic lateral sclerosis (ALS) and spinal muscular
    atrophy (SMA). Although some disease hallmarks have
    been reported in patient-derived stem cell models, it is
    proving more difficult to recapitulate the full phenotypic
    extent of these disorders. The problem with these stem
    cell models lies in the disparity between the advanced
    age of onset of neurodegenerative disorders and the
    embryonic nature of the in vitro derived cell types. In
    this review we discuss experimental methods of in vitro
    aging of neural cell types as a means to elicit late-onset
    symptoms in induced pluripotent stem cell (iPSC) models
    of neurodegenerative disease.
    Original languageEnglish
    Pages (from-to)642-652
    Number of pages11
    JournalTrends in Neurosciences
    Volume37
    Issue number11
    DOIs
    Publication statusPublished - Nov 2014

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