Microphysiological Systems to Recapitulate the Gut–Kidney Axis

Laura Giordano; Silvia Maria Mihaila; Hossein Eslami Amirabadi; Rosalinde Masereeuw

doi:10.1016/j.tibtech.2020.12.001

Microphysiological Systems to Recapitulate the Gut–Kidney Axis

Laura Giordano, Silvia Maria Mihaila, Hossein Eslami Amirabadi, Rosalinde Masereeuw^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have emerged as promising approaches for emulating the in vitro interconnection of multiple organs, while addressing the limitations of animal models. Mimicking the (patho)physiological states of the gut–kidney axis in vitro requires an MPS that can simulate not only this direct bidirectional crosstalk but also the contributions of other physiological participants such as the liver and the immune system. We discuss recent developments in the field that could potentially lead to in vitro modeling of the gut–kidney axis in CKD.

Original language	English
Pages (from-to)	811-823
Number of pages	13
Journal	Trends in Biotechnology
Volume	39
Issue number	8
Early online date	5 Jan 2021
DOIs	https://doi.org/10.1016/j.tibtech.2020.12.001
Publication status	Published - Aug 2021

Bibliographical note

Funding Information:
This project received funding from the EU Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement STRATEGY-CKD H2020-2019-ETN ( 860329 ), as well as the WIDESPREAD-05-2018-TWINNING call REMODEL ( 857491 ). This work was further supported by the Dutch Kidney Foundation (DKF, 17OI13 ). R.M. is a member of the ESAO/ERA-EDTA-endorsed Work Group EUTox.

Funding Information:
This project received funding from the EU Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie grant agreement STRATEGY-CKD H2020-2019-ETN (860329), as well as the WIDESPREAD-05-2018-TWINNING call REMODEL (857491). This work was further supported by the Dutch Kidney Foundation (DKF, 17OI13). R.M. is a member of the ESAO/ERA-EDTA-endorsed Work Group EUTox.

Publisher Copyright:
© 2020 The Authors

Funding

This project received funding from the EU Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement STRATEGY-CKD H2020-2019-ETN ( 860329 ), as well as the WIDESPREAD-05-2018-TWINNING call REMODEL ( 857491 ). This work was further supported by the Dutch Kidney Foundation (DKF, 17OI13 ). R.M. is a member of the ESAO/ERA-EDTA-endorsed Work Group EUTox.

Keywords

chronic kidney disease
gut–kidney axis
microphysiological systems
remote signaling
uremic toxins

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10.1016/j.tibtech.2020.12.001Licence: CC BY

PIIS0167779920303255Final published version, 2.75 MBLicence: CC BY

Cite this

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title = "Microphysiological Systems to Recapitulate the Gut–Kidney Axis",

abstract = "Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have emerged as promising approaches for emulating the in vitro interconnection of multiple organs, while addressing the limitations of animal models. Mimicking the (patho)physiological states of the gut–kidney axis in vitro requires an MPS that can simulate not only this direct bidirectional crosstalk but also the contributions of other physiological participants such as the liver and the immune system. We discuss recent developments in the field that could potentially lead to in vitro modeling of the gut–kidney axis in CKD.",

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author = "Laura Giordano and Mihaila, {Silvia Maria} and {Eslami Amirabadi}, Hossein and Rosalinde Masereeuw",

note = "Funding Information: This project received funding from the EU Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement STRATEGY-CKD H2020-2019-ETN ( 860329 ), as well as the WIDESPREAD-05-2018-TWINNING call REMODEL ( 857491 ). This work was further supported by the Dutch Kidney Foundation (DKF, 17OI13 ). R.M. is a member of the ESAO/ERA-EDTA-endorsed Work Group EUTox. Funding Information: This project received funding from the EU Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie grant agreement STRATEGY-CKD H2020-2019-ETN (860329), as well as the WIDESPREAD-05-2018-TWINNING call REMODEL (857491). This work was further supported by the Dutch Kidney Foundation (DKF, 17OI13). R.M. is a member of the ESAO/ERA-EDTA-endorsed Work Group EUTox. Publisher Copyright: {\textcopyright} 2020 The Authors",

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Microphysiological Systems to Recapitulate the Gut–Kidney Axis

Abstract

Bibliographical note

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Keywords

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