MHC class II molecules: transport pathways for antigen presentation

R Wubbolts; M Fernandez-Bona; J Neefjes

doi:10.1016/S0962-8924(97)01000-3

MHC class II molecules: transport pathways for antigen presentation

R Wubbolts, M Fernandez-Bona, J Neefjes

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific antibody responses. Therefore, the study of class II molecules is important in understanding how cell-biological events can direct an immune response.

Original language	English
Pages (from-to)	115-8
Number of pages	4
Journal	Trends in Cell Biology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/S0962-8924(97)01000-3
Publication status	Published - 1997

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@article{1b180c5e9d004afba4b3ad548c6ba191,

title = "MHC class II molecules: transport pathways for antigen presentation",

abstract = "During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific antibody responses. Therefore, the study of class II molecules is important in understanding how cell-biological events can direct an immune response.",

author = "R Wubbolts and M Fernandez-Bona and J Neefjes",

year = "1997",

doi = "10.1016/S0962-8924(97)01000-3",

language = "English",

volume = "7",

pages = "115--8",

journal = "Trends in Cell Biology",

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T1 - MHC class II molecules: transport pathways for antigen presentation

AU - Wubbolts, R

AU - Fernandez-Bona, M

AU - Neefjes, J

PY - 1997

Y1 - 1997

N2 - During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific antibody responses. Therefore, the study of class II molecules is important in understanding how cell-biological events can direct an immune response.

AB - During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific antibody responses. Therefore, the study of class II molecules is important in understanding how cell-biological events can direct an immune response.

U2 - 10.1016/S0962-8924(97)01000-3

DO - 10.1016/S0962-8924(97)01000-3

M3 - Article

C2 - 17708920

SN - 0962-8924

VL - 7

SP - 115

EP - 118

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 3

ER -

MHC class II molecules: transport pathways for antigen presentation

Abstract

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