Metabolic regulation by p53 family members

Celia R. Berkers; Oliver D.K. Maddocks; Eric C. Cheung; Inbal Mor; Karen H. Vousden

doi:10.1016/j.cmet.2013.06.019

Metabolic regulation by p53 family members

Celia R. Berkers
, Oliver D.K. Maddocks
, Eric C. Cheung
, Inbal Mor
, Karen H. Vousden

CR-UK Beatson Institute

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs. © 2013 The Authors.

Original language	English
Pages (from-to)	617-633
Number of pages	17
Journal	Cell Metabolism
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2013.06.019
Publication status	Published - 5 Nov 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

hydroxymethylglutaryl coenzyme A reductase kinase
mammalian target of rapamycin
mammalian target of rapamycin complex 1
peroxisome proliferator activated receptor gamma coactivator 1alpha
protein p53
protein p63
protein p73
reactive oxygen metabolite
sterol regulatory element binding protein
transcription factor Nrf2
aging
autophagy
carbohydrate metabolism
carbon metabolism
diabetes mellitus
homeostasis
human
lipid metabolism
metabolic regulation
metabolic syndrome X
metabolism
neoplasm
priority journal
protein family
protein function
protein protein interaction
review

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10.1016/j.cmet.2013.06.019

Cite this

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title = "Metabolic regulation by p53 family members",

abstract = "The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs. {\textcopyright} 2013 The Authors.",

keywords = "hydroxymethylglutaryl coenzyme A reductase kinase, mammalian target of rapamycin, mammalian target of rapamycin complex 1, peroxisome proliferator activated receptor gamma coactivator 1alpha, protein p53, protein p63, protein p73, reactive oxygen metabolite, sterol regulatory element binding protein, transcription factor Nrf2, aging, autophagy, carbohydrate metabolism, carbon metabolism, diabetes mellitus, homeostasis, human, lipid metabolism, metabolic regulation, metabolic syndrome X, metabolism, neoplasm, priority journal, protein family, protein function, protein protein interaction, review",

author = "Berkers, \{Celia R.\} and Maddocks, \{Oliver D.K.\} and Cheung, \{Eric C.\} and Inbal Mor and Vousden, \{Karen H.\}",

year = "2013",

month = nov,

day = "5",

doi = "10.1016/j.cmet.2013.06.019",

language = "English",

volume = "18",

pages = "617--633",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Metabolic regulation by p53 family members

AU - Berkers, Celia R.

AU - Maddocks, Oliver D.K.

AU - Cheung, Eric C.

AU - Mor, Inbal

AU - Vousden, Karen H.

PY - 2013/11/5

Y1 - 2013/11/5

N2 - The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs. © 2013 The Authors.

AB - The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs. © 2013 The Authors.

KW - hydroxymethylglutaryl coenzyme A reductase kinase

KW - mammalian target of rapamycin

KW - mammalian target of rapamycin complex 1

KW - peroxisome proliferator activated receptor gamma coactivator 1alpha

KW - protein p53

KW - protein p63

KW - protein p73

KW - reactive oxygen metabolite

KW - sterol regulatory element binding protein

KW - transcription factor Nrf2

KW - aging

KW - autophagy

KW - carbohydrate metabolism

KW - carbon metabolism

KW - diabetes mellitus

KW - homeostasis

KW - human

KW - lipid metabolism

KW - metabolic regulation

KW - metabolic syndrome X

KW - metabolism

KW - neoplasm

KW - priority journal

KW - protein family

KW - protein function

KW - protein protein interaction

KW - review

U2 - 10.1016/j.cmet.2013.06.019

DO - 10.1016/j.cmet.2013.06.019

M3 - Article

SN - 1550-4131

VL - 18

SP - 617

EP - 633

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

Metabolic regulation by p53 family members

Abstract

UN SDGs

Keywords

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