Abstract
The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs. © 2013 The Authors.
| Original language | English |
|---|---|
| Pages (from-to) | 617-633 |
| Number of pages | 17 |
| Journal | Cell Metabolism |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 5 Nov 2013 |
| Externally published | Yes |
Keywords
- hydroxymethylglutaryl coenzyme A reductase kinase
- mammalian target of rapamycin
- mammalian target of rapamycin complex 1
- peroxisome proliferator activated receptor gamma coactivator 1alpha
- protein p53
- protein p63
- protein p73
- reactive oxygen metabolite
- sterol regulatory element binding protein
- transcription factor Nrf2
- aging
- autophagy
- carbohydrate metabolism
- carbon metabolism
- diabetes mellitus
- homeostasis
- human
- lipid metabolism
- metabolic regulation
- metabolic syndrome X
- metabolism
- neoplasm
- priority journal
- protein family
- protein function
- protein protein interaction
- review
