Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors

Seyed H. Mahmoudpour; Abirami Veluchamy; Moneeza K. Siddiqui; Folkert W. Asselbergs; Patrick C. Souverein; Catherine E. De Keyser; Albert Hofman; Chim C. Lang; Alexander S.F. Doney; Bruno H. Stricker; Anthonius De Boer; Anke H. Maitland-Van Der Zee; Colin N.A. Palmer

doi:10.1097/FPC.0000000000000264

Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors

Seyed H. Mahmoudpour, Abirami Veluchamy, Moneeza K. Siddiqui, Folkert W. Asselbergs, Patrick C. Souverein, Catherine E. De Keyser, Albert Hofman, Chim C. Lang, Alexander S.F. Doney, Bruno H. Stricker, Anthonius De Boer, Anke H. Maitland-Van Der Zee, Colin N.A. Palmer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives To identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin receptor blocker. Methods Two cohorts of patients starting ACE-inhibitors were identified within the Rotterdam Study in the Netherlands and the Genetics of Diabetes Audit and Research in Tayside Scotland study in Scotland. Cases were intolerant patients who switched from an ACE-inhibitor to an angiotensin receptor blocker and controls were individuals who used ACE-inhibitors continuously for at least 2 years and did not switch. Genome-wide association study (GWAS) using an additive model was run in these sets and the results were meta-analysed using Genome-Wide Association Meta Analysis software. Results A total of 972 cases out of 5161 ACE-inhibitor starters were identified. Eight SNPs within four genes reached the genome-wide association study significance level (P

Original language	English
Pages (from-to)	112-119
Number of pages	8
Journal	Pharmacogenetics and Genomics
Volume	27
Issue number	3
DOIs	https://doi.org/10.1097/FPC.0000000000000264
Publication status	Published - 1 Apr 2017

Keywords

adverse drug reaction
angio-oedema
angiotensin-converting enzyme inhibitors
angiotensin-converting enzyme-inhibitor intolerance
cough
genome-wide association study
4 aminobutyric acid A receptor gamma2
acyltransferase
adaptor protein
adaptor protein 1
angiotensin receptor antagonist
dipeptidyl carboxypeptidase inhibitor
Fox 1 protein
membrane bound o acetyltransferase domain containing 1 protein
membrane protein
o acyltransferase domain containing 1
protein SH2
protein tyrosine kinase
RNA binding protein
unclassified drug
adult
article
cohort analysis
controlled study
drug hypersensitivity
drug substitution
drug withdrawal
female
gene frequency
genetic variation
human
major clinical study
male
middle aged
priority journal
single nucleotide polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/FPC.0000000000000264

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Mahmoudpour, S. H., Veluchamy, A., Siddiqui, M. K., Asselbergs, F. W., Souverein, P. C., De Keyser, C. E., Hofman, A., Lang, C. C., Doney, A. S. F., Stricker, B. H., De Boer, A., Maitland-Van Der Zee, A. H., & Palmer, C. N. A. (2017). Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors. Pharmacogenetics and Genomics, 27(3), 112-119. https://doi.org/10.1097/FPC.0000000000000264

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abstract = "Objectives To identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin receptor blocker. Methods Two cohorts of patients starting ACE-inhibitors were identified within the Rotterdam Study in the Netherlands and the Genetics of Diabetes Audit and Research in Tayside Scotland study in Scotland. Cases were intolerant patients who switched from an ACE-inhibitor to an angiotensin receptor blocker and controls were individuals who used ACE-inhibitors continuously for at least 2 years and did not switch. Genome-wide association study (GWAS) using an additive model was run in these sets and the results were meta-analysed using Genome-Wide Association Meta Analysis software. Results A total of 972 cases out of 5161 ACE-inhibitor starters were identified. Eight SNPs within four genes reached the genome-wide association study significance level (P",

keywords = "adverse drug reaction, angio-oedema, angiotensin-converting enzyme inhibitors, angiotensin-converting enzyme-inhibitor intolerance, cough, genome-wide association study, 4 aminobutyric acid A receptor gamma2, acyltransferase, adaptor protein, adaptor protein 1, angiotensin receptor antagonist, dipeptidyl carboxypeptidase inhibitor, Fox 1 protein, membrane bound o acetyltransferase domain containing 1 protein, membrane protein, o acyltransferase domain containing 1, protein SH2, protein tyrosine kinase, RNA binding protein, unclassified drug, adult, article, cohort analysis, controlled study, drug hypersensitivity, drug substitution, drug withdrawal, female, gene frequency, genetic variation, human, major clinical study, male, middle aged, priority journal, single nucleotide polymorphism",

author = "Mahmoudpour, {Seyed H.} and Abirami Veluchamy and Siddiqui, {Moneeza K.} and Asselbergs, {Folkert W.} and Souverein, {Patrick C.} and {De Keyser}, {Catherine E.} and Albert Hofman and Lang, {Chim C.} and Doney, {Alexander S.F.} and Stricker, {Bruno H.} and {De Boer}, Anthonius and {Maitland-Van Der Zee}, {Anke H.} and Palmer, {Colin N.A.}",

year = "2017",

month = apr,

day = "1",

doi = "10.1097/FPC.0000000000000264",

language = "English",

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pages = "112--119",

journal = "Pharmacogenetics and Genomics",

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Mahmoudpour, SH, Veluchamy, A, Siddiqui, MK, Asselbergs, FW, Souverein, PC, De Keyser, CE, Hofman, A, Lang, CC, Doney, ASF, Stricker, BH, De Boer, A, Maitland-Van Der Zee, AH & Palmer, CNA 2017, 'Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors', Pharmacogenetics and Genomics, vol. 27, no. 3, pp. 112-119. https://doi.org/10.1097/FPC.0000000000000264

TY - JOUR

T1 - Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors

AU - Mahmoudpour, Seyed H.

AU - Veluchamy, Abirami

AU - Siddiqui, Moneeza K.

AU - Asselbergs, Folkert W.

AU - Souverein, Patrick C.

AU - De Keyser, Catherine E.

AU - Hofman, Albert

AU - Lang, Chim C.

AU - Doney, Alexander S.F.

AU - Stricker, Bruno H.

AU - De Boer, Anthonius

AU - Maitland-Van Der Zee, Anke H.

AU - Palmer, Colin N.A.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objectives To identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin receptor blocker. Methods Two cohorts of patients starting ACE-inhibitors were identified within the Rotterdam Study in the Netherlands and the Genetics of Diabetes Audit and Research in Tayside Scotland study in Scotland. Cases were intolerant patients who switched from an ACE-inhibitor to an angiotensin receptor blocker and controls were individuals who used ACE-inhibitors continuously for at least 2 years and did not switch. Genome-wide association study (GWAS) using an additive model was run in these sets and the results were meta-analysed using Genome-Wide Association Meta Analysis software. Results A total of 972 cases out of 5161 ACE-inhibitor starters were identified. Eight SNPs within four genes reached the genome-wide association study significance level (P

AB - Objectives To identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin receptor blocker. Methods Two cohorts of patients starting ACE-inhibitors were identified within the Rotterdam Study in the Netherlands and the Genetics of Diabetes Audit and Research in Tayside Scotland study in Scotland. Cases were intolerant patients who switched from an ACE-inhibitor to an angiotensin receptor blocker and controls were individuals who used ACE-inhibitors continuously for at least 2 years and did not switch. Genome-wide association study (GWAS) using an additive model was run in these sets and the results were meta-analysed using Genome-Wide Association Meta Analysis software. Results A total of 972 cases out of 5161 ACE-inhibitor starters were identified. Eight SNPs within four genes reached the genome-wide association study significance level (P

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KW - drug withdrawal

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KW - genetic variation

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DO - 10.1097/FPC.0000000000000264

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SN - 1744-6872

VL - 27

SP - 112

EP - 119

JO - Pharmacogenetics and Genomics

JF - Pharmacogenetics and Genomics

IS - 3

ER -

Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors

Abstract

Keywords

UN SDGs

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