Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

Olena Gruzieva; Ulrike Gehring; Rob Aalberse; Raymond Agius; Rob Beelen; Heidrun Behrendt; Tom Bellander; Matthias Birk; Johan C. de Jongste; Elaine Fuertes; Joachim Heinrich; Gerard Hoek; Claudia Kluemper; Gerard Koppelman; Michal Korek; Ursula Kraemer; Sarah Lindley; Anna Moelter; Angela Simpson; Marie Standl; Marianne van Hage; Andrea von Berg; Alet Wijga; Bert Brunekreef; Goeran Pershagen

doi:10.1016/j.jaci.2013.07.048

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

Olena Gruzieva^*, Ulrike Gehring, Rob Aalberse, Raymond Agius, Rob Beelen, Heidrun Behrendt, Tom Bellander, Matthias Birk, Johan C. de Jongste, Elaine Fuertes, Joachim Heinrich, Gerard Hoek, Claudia Kluemper, Gerard Koppelman, Michal Korek, Ursula Kraemer, Sarah Lindley, Anna Moelter, Angela Simpson, Marie StandlMarianne van Hage, Andrea von Berg, Alet Wijga, Bert Brunekreef, Goeran Pershagen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Evidence on the long-term effects of air pollution exposure on childhood allergy is limited.

Objective: We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life.

Methods: Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 mm (PM2.5), the mass concentration of particles between 2.5 and 10 mm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 mm (PM10), as well as measurement of the blackness of PM2.5 filters and nitrogendioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis.

Results: The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 x 10(-5) . m(-1) increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 mu g/m(3) increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status.

Conclusion: No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.

Original language	English
Pages (from-to)	767-+
Number of pages	17
Journal	Journal of Allergy and Clinical Immunology
Volume	133
Issue number	3
DOIs	https://doi.org/10.1016/j.jaci.2013.07.048
Publication status	Published - Mar 2014

Funding

The research leading to these results has received funding from the European Community's Seventh Framework Program (FP7/2007-2011) under grant agreement no. 211250. The BAMSE study was supported by the Swedish Heart-Lung Foundation, the Konsul ThC Bergh Foundation, the Stockholm County Council, the Swedish Asthma and Allergy Association Research Foundation, the Swedish Foundation for Health Care Sciences and Allergy Research, the Swedish Environmental Protection Agency. The PIAMA study is supported by the Netherlands Organization for Health Research and Development; the Netherlands Organization for Scientific Research; the Netherlands Asthma Fund; the Netherlands Ministry of Spatial Planning, Housing, and the Environment; and the Netherlands Ministry of Health, Welfare, and Sport. The GINIplus study was mainly supported for the first 3 years of the Federal Ministry for Education, Science, Research and Technology (interventional arm) and Helmholtz Zentrum Munich (formerly GSF; observational arm). The 4-year, 6-year, and 10-year follow-up examinations of the GINIplus study were covered from the respective budgets of the 5 study centres (Helmholtz Zentrum Munich [formerly GSF], Research Institute, Department of Pediatrics, Marien-Hospital Wesel, LMU Munich, TU Munich, and from 6 years onward also from IUF-Leibniz Research Institute for Environmental Medicine) and a grant from the Federal Ministry for Environment. The LISAplus study was mainly supported by grants from the Federal Ministry for Education, Science, Research and Technology and in addition from Helmholtz Zentrum Munich (formerly GSF), Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute, Department of Pediatrics, MarienHospital Wesel, Pediatric Practice, Bad Honnef for the first 2 years. The 4-year, 6-year, and 10-year follow-up examinations of the LISAplus study were covered from the respective budgets of the involved partners (Helmholtz Zentrum Munich [formerly GSF], Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute, Department of Pediatrics, Marien-Hospital Wesel, Pediatric Practice, Bad Honnef, IUF-Leibniz-Research Institute for Environmental Medicine) and in addition by a grant from the Federal Ministry for Environment. The MAAS study was supported by Asthma UK grant and the Moulton Charitable Trust.

Keywords

Air pollution
children
cohort
IgE
sensitization
meta-analysis
European Study of Cohorts for Air Pollution Effects
USE REGRESSION-MODELS
PM2.5 ABSORBENCY
ESCAPE PROJECT
ASTHMA
AREAS
CHILDREN
NO2
INFORMATION
CHILDHOOD
STABILITY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaci.2013.07.048

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Cite this

Gruzieva, O., Gehring, U., Aalberse, R., Agius, R., Beelen, R., Behrendt, H., Bellander, T., Birk, M., de Jongste, J. C., Fuertes, E., Heinrich, J., Hoek, G., Kluemper, C., Koppelman, G., Korek, M., Kraemer, U., Lindley, S., Moelter, A., Simpson, A., ... Pershagen, G. (2014). Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts. Journal of Allergy and Clinical Immunology, 133(3), 767-+. https://doi.org/10.1016/j.jaci.2013.07.048

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title = "Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts",

abstract = "Background: Evidence on the long-term effects of air pollution exposure on childhood allergy is limited.Objective: We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life.Methods: Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 mm (PM2.5), the mass concentration of particles between 2.5 and 10 mm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 mm (PM10), as well as measurement of the blackness of PM2.5 filters and nitrogendioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis.Results: The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 x 10(-5) . m(-1) increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 mu g/m(3) increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status.Conclusion: No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.",

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author = "Olena Gruzieva and Ulrike Gehring and Rob Aalberse and Raymond Agius and Rob Beelen and Heidrun Behrendt and Tom Bellander and Matthias Birk and {de Jongste}, {Johan C.} and Elaine Fuertes and Joachim Heinrich and Gerard Hoek and Claudia Kluemper and Gerard Koppelman and Michal Korek and Ursula Kraemer and Sarah Lindley and Anna Moelter and Angela Simpson and Marie Standl and {van Hage}, Marianne and {von Berg}, Andrea and Alet Wijga and Bert Brunekreef and Goeran Pershagen",

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doi = "10.1016/j.jaci.2013.07.048",

language = "English",

volume = "133",

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journal = "Journal of Allergy and Clinical Immunology",

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Gruzieva, O, Gehring, U, Aalberse, R, Agius, R, Beelen, R, Behrendt, H, Bellander, T, Birk, M, de Jongste, JC, Fuertes, E, Heinrich, J, Hoek, G, Kluemper, C, Koppelman, G, Korek, M, Kraemer, U, Lindley, S, Moelter, A, Simpson, A, Standl, M, van Hage, M, von Berg, A, Wijga, A, Brunekreef, B & Pershagen, G 2014, 'Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts', Journal of Allergy and Clinical Immunology, vol. 133, no. 3, pp. 767-+. https://doi.org/10.1016/j.jaci.2013.07.048

TY - JOUR

T1 - Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

AU - Gruzieva, Olena

AU - Gehring, Ulrike

AU - Aalberse, Rob

AU - Agius, Raymond

AU - Beelen, Rob

AU - Behrendt, Heidrun

AU - Bellander, Tom

AU - Birk, Matthias

AU - de Jongste, Johan C.

AU - Fuertes, Elaine

AU - Heinrich, Joachim

AU - Hoek, Gerard

AU - Kluemper, Claudia

AU - Koppelman, Gerard

AU - Korek, Michal

AU - Kraemer, Ursula

AU - Lindley, Sarah

AU - Moelter, Anna

AU - Simpson, Angela

AU - Standl, Marie

AU - van Hage, Marianne

AU - von Berg, Andrea

AU - Wijga, Alet

AU - Brunekreef, Bert

AU - Pershagen, Goeran

PY - 2014/3

Y1 - 2014/3

N2 - Background: Evidence on the long-term effects of air pollution exposure on childhood allergy is limited.Objective: We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life.Methods: Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 mm (PM2.5), the mass concentration of particles between 2.5 and 10 mm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 mm (PM10), as well as measurement of the blackness of PM2.5 filters and nitrogendioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis.Results: The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 x 10(-5) . m(-1) increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 mu g/m(3) increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status.Conclusion: No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.

AB - Background: Evidence on the long-term effects of air pollution exposure on childhood allergy is limited.Objective: We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life.Methods: Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 mm (PM2.5), the mass concentration of particles between 2.5 and 10 mm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 mm (PM10), as well as measurement of the blackness of PM2.5 filters and nitrogendioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis.Results: The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 x 10(-5) . m(-1) increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 mu g/m(3) increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status.Conclusion: No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.

KW - Air pollution

KW - children

KW - cohort

KW - IgE

KW - sensitization

KW - meta-analysis

KW - European Study of Cohorts for Air Pollution Effects

KW - USE REGRESSION-MODELS

KW - PM2.5 ABSORBENCY

KW - ESCAPE PROJECT

KW - ASTHMA

KW - AREAS

KW - CHILDREN

KW - NO2

KW - INFORMATION

KW - CHILDHOOD

KW - STABILITY

U2 - 10.1016/j.jaci.2013.07.048

DO - 10.1016/j.jaci.2013.07.048

M3 - Article

SN - 0091-6749

VL - 133

SP - 767-+

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

Abstract

Funding

Keywords

UN SDGs

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