Membrane domain formation - a key factor for targeted intracellular drug delivery

Dusan Popov-Celeketic; P van Bergen en Henegouwen

doi:10.3389/fphys.2014.00462

Membrane domain formation - a key factor for targeted intracellular drug delivery

Dusan Popov-Celeketic, P van Bergen en Henegouwen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Proteinmolecules,toxinsandvirusesinternalizeintothecellviareceptor-mediatedendocytosis(RME)usingspecificproteinsandlipidsintheplasmamembrane.Theplasmamembraneisabarrierformanypharmaceuticalagentstoenterintothecytoplasmoftargetcells.Inthecaseofcancercells,tissue-specificbiomarkersintheplasmamembrane,likecancer-specificgrowthfactorreceptors,couldbeexcellentcandidatesforRME-dependentdrugdelivery.Recentdatasuggestthatagentbindingtothesereceptorsatthecellsurface,resultinginmembranedomainformationbyreceptorclustering,canbeusedfortheinitiationofRME.Asaresult,thesepharmaceuticalagentsareinternalizedintothecellsandfollowdifferentroutesuntiltheyreachtheirfinalintracellulartargetslikelysosomesorGolgi.Weproposethatclusteringinducedformationofplasmamembranemicrodomainsenrichedinreceptors,sphingolipids,andinositollipids,leadstomembranebendingwhichfunctionsastheonsetofRME.InthisreviewwewillfocusontheroleofdomainformationinRMEanddiscusspotentialapplicationsfortargetedintracellulardrugdelivery.

Original language	English
Pages (from-to)	462
Journal	Frontiers in Physiology [E]
Volume	5
DOIs	https://doi.org/10.3389/fphys.2014.00462
Publication status	Published - 2014

Keywords

membran edomain
receptor mediated endocytosis
EGFR
receptor clustering
drug delivery
cancer therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fphys.2014.00462

fphys-05-00462Final published version, 846 KB

http://www.ncbi.nlm.nih.gov/pubmed/?term=Membrane+domain+formation+-+a+key+factor+for+targeted+intracellular+drug+delivery

Cite this

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title = "Membrane domain formation - a key factor for targeted intracellular drug delivery",

abstract = "Proteinmolecules,toxinsandvirusesinternalizeintothecellviareceptor-mediatedendocytosis(RME)usingspecificproteinsandlipidsintheplasmamembrane.Theplasmamembraneisabarrierformanypharmaceuticalagentstoenterintothecytoplasmoftargetcells.Inthecaseofcancercells,tissue-specificbiomarkersintheplasmamembrane,likecancer-specificgrowthfactorreceptors,couldbeexcellentcandidatesforRME-dependentdrugdelivery.Recentdatasuggestthatagentbindingtothesereceptorsatthecellsurface,resultinginmembranedomainformationbyreceptorclustering,canbeusedfortheinitiationofRME.Asaresult,thesepharmaceuticalagentsareinternalizedintothecellsandfollowdifferentroutesuntiltheyreachtheirfinalintracellulartargetslikelysosomesorGolgi.Weproposethatclusteringinducedformationofplasmamembranemicrodomainsenrichedinreceptors,sphingolipids,andinositollipids,leadstomembranebendingwhichfunctionsastheonsetofRME.InthisreviewwewillfocusontheroleofdomainformationinRMEanddiscusspotentialapplicationsfortargetedintracellulardrugdelivery.",

keywords = "membran edomain, receptor mediated endocytosis, EGFR, receptor clustering, drug delivery, cancer therapy ",

author = "Dusan Popov-Celeketic and \{van Bergen en Henegouwen\}, P",

year = "2014",

doi = "10.3389/fphys.2014.00462",

language = "English",

volume = "5",

pages = "462",

journal = "Frontiers in Physiology [E]",

issn = "1664-042X",

publisher = "Frontiers Media SA",

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TY - JOUR

T1 - Membrane domain formation - a key factor for targeted intracellular drug delivery

AU - Popov-Celeketic, Dusan

AU - van Bergen en Henegouwen, P

PY - 2014

Y1 - 2014

N2 - Proteinmolecules,toxinsandvirusesinternalizeintothecellviareceptor-mediatedendocytosis(RME)usingspecificproteinsandlipidsintheplasmamembrane.Theplasmamembraneisabarrierformanypharmaceuticalagentstoenterintothecytoplasmoftargetcells.Inthecaseofcancercells,tissue-specificbiomarkersintheplasmamembrane,likecancer-specificgrowthfactorreceptors,couldbeexcellentcandidatesforRME-dependentdrugdelivery.Recentdatasuggestthatagentbindingtothesereceptorsatthecellsurface,resultinginmembranedomainformationbyreceptorclustering,canbeusedfortheinitiationofRME.Asaresult,thesepharmaceuticalagentsareinternalizedintothecellsandfollowdifferentroutesuntiltheyreachtheirfinalintracellulartargetslikelysosomesorGolgi.Weproposethatclusteringinducedformationofplasmamembranemicrodomainsenrichedinreceptors,sphingolipids,andinositollipids,leadstomembranebendingwhichfunctionsastheonsetofRME.InthisreviewwewillfocusontheroleofdomainformationinRMEanddiscusspotentialapplicationsfortargetedintracellulardrugdelivery.

AB - Proteinmolecules,toxinsandvirusesinternalizeintothecellviareceptor-mediatedendocytosis(RME)usingspecificproteinsandlipidsintheplasmamembrane.Theplasmamembraneisabarrierformanypharmaceuticalagentstoenterintothecytoplasmoftargetcells.Inthecaseofcancercells,tissue-specificbiomarkersintheplasmamembrane,likecancer-specificgrowthfactorreceptors,couldbeexcellentcandidatesforRME-dependentdrugdelivery.Recentdatasuggestthatagentbindingtothesereceptorsatthecellsurface,resultinginmembranedomainformationbyreceptorclustering,canbeusedfortheinitiationofRME.Asaresult,thesepharmaceuticalagentsareinternalizedintothecellsandfollowdifferentroutesuntiltheyreachtheirfinalintracellulartargetslikelysosomesorGolgi.Weproposethatclusteringinducedformationofplasmamembranemicrodomainsenrichedinreceptors,sphingolipids,andinositollipids,leadstomembranebendingwhichfunctionsastheonsetofRME.InthisreviewwewillfocusontheroleofdomainformationinRMEanddiscusspotentialapplicationsfortargetedintracellulardrugdelivery.

KW - membran edomain

KW - receptor mediated endocytosis

KW - EGFR

KW - receptor clustering

KW - drug delivery

KW - cancer therapy

U2 - 10.3389/fphys.2014.00462

DO - 10.3389/fphys.2014.00462

M3 - Article

SN - 1664-042X

VL - 5

SP - 462

JO - Frontiers in Physiology [E]

JF - Frontiers in Physiology [E]

ER -

Membrane domain formation - a key factor for targeted intracellular drug delivery

Abstract

Keywords

UN SDGs

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