Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

Marieke A Stammes, Ji Hyun Lee, Lisette Meijer, Thibaut Naninck, Lara A Doyle-Meyers, Alexander G White, H Jacob Borish, Amy L Hartman, Xavier Alvarez, Shashank Ganatra, Deepak Kaushal, Rudolf P Bohm, Roger le Grand, Charles A Scanga, Jan A M Langermans, Ronald E Bontrop, Courtney L Finch, JoAnne L Flynn, Claudia Calcagno, Ian CrozierJens H Kuhn

Research output: Contribution to journalReview articlepeer-review

Abstract

Chest X-ray (CXR), computed tomography (CT), and positron emission tomography-computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.

Original languageEnglish
Pages (from-to)123-142
Number of pages20
JournalTrends in Molecular Medicine
Volume28
Issue number2
Early online date7 Dec 2021
DOIs
Publication statusPublished - 1 Feb 2022

Keywords

  • COVID-19
  • SARS-CoV-2
  • imaging
  • lung
  • non-human primate

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