Maternal antibodies to fetal platelets: a complex-related story

Although our findings did not reveal a definitive antibody signature for severe disease, the previously proposed biomarker of αvβ3-specific antibodies has been questioned and falsified. Other features such as glycosylation and functional properties have been emerged as more relevant predictors. Given the complexity of the immune response, it is unlikely that a single biomarker will be predictive but rather a panel of markers is needed. We support the initiation of a screening program based on current knowledge which can be refined over time as more data becomes available.