Abstract
The objectives were to conduct a meta-analysis in accordance with Preferred Reporting Items for Systematic Reviews and
Meta-Analyses (PRISMA) standards to determine effect sizes (Cohen’s d) for cognitive dysfunction in adults with type 2
diabetes, relative to nondiabetic controls, and to obtain effect sizes for the most commonly reported neuropsychological
tests within domains. Twenty-four studies, totaling 26,137 patients (n53351 with diabetes), met study inclusion criteria.
Small to moderate effect sizes were obtained for five of six domains: motor function (3 studies, n52374; d520.36),
executive function (12 studies, n51784; d520.33), processing speed (16 studies, n53076; d520.33), verbal
memory (15 studies, n54,608; d520.28), and visual memory (6 studies, n51754; d520.26). Effect size was
smallest for attention/concentration (14 studies, n523,143; d520.19). The following tests demonstrated the most
notable performance decrements in diabetes samples: Grooved Pegboard (dominant hand) (d520.60), Rey Auditory
Verbal Learning Test (immediate) (d520.40), Trails B (d520.39), Rey-Osterreith Complex Figure (delayed)
(d520.38), Trails A (d520.34), and Stroop Part I (d520.28). This study provides effect sizes to power future
epidemiological and clinical diabetes research studies examining cognitive function and to help inform the selection of
neuropsychological tests.
Meta-Analyses (PRISMA) standards to determine effect sizes (Cohen’s d) for cognitive dysfunction in adults with type 2
diabetes, relative to nondiabetic controls, and to obtain effect sizes for the most commonly reported neuropsychological
tests within domains. Twenty-four studies, totaling 26,137 patients (n53351 with diabetes), met study inclusion criteria.
Small to moderate effect sizes were obtained for five of six domains: motor function (3 studies, n52374; d520.36),
executive function (12 studies, n51784; d520.33), processing speed (16 studies, n53076; d520.33), verbal
memory (15 studies, n54,608; d520.28), and visual memory (6 studies, n51754; d520.26). Effect size was
smallest for attention/concentration (14 studies, n523,143; d520.19). The following tests demonstrated the most
notable performance decrements in diabetes samples: Grooved Pegboard (dominant hand) (d520.60), Rey Auditory
Verbal Learning Test (immediate) (d520.40), Trails B (d520.39), Rey-Osterreith Complex Figure (delayed)
(d520.38), Trails A (d520.34), and Stroop Part I (d520.28). This study provides effect sizes to power future
epidemiological and clinical diabetes research studies examining cognitive function and to help inform the selection of
neuropsychological tests.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 278-291 |
| Number of pages | 14 |
| Journal | Journal of the International Neuropsychological Society |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- Central nervous system
- Endocrine
- Assessment
- Metabolic disorders
- Chronic disease
- Cardiovascular disease