Lysosomes nor Mice Move Forward without Borcs7

Urjita Joshi; Joseline A Houwman; Peter van der Sluijs

doi:10.1016/j.tcb.2018.08.002

Lysosomes nor Mice Move Forward without Borcs7

Urjita Joshi, Joseline A Houwman, Peter van der Sluijs

Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function.

Original language	English
Pages (from-to)	761-763
Number of pages	3
Journal	Trends in Cell Biology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.tcb.2018.08.002
Publication status	Published - 2018

Keywords

Borcs7
lysosome positioning
axonal dystrophy
autophagy

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10.1016/j.tcb.2018.08.002

joshiFinal published version, 606 KBLicence: Taverne

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title = "Lysosomes nor Mice Move Forward without Borcs7",

abstract = "Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function.",

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author = "Urjita Joshi and Houwman, {Joseline A} and {van der Sluijs}, Peter",

year = "2018",

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AU - Joshi, Urjita

AU - Houwman, Joseline A

AU - van der Sluijs, Peter

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AB - Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function.

KW - Borcs7

KW - lysosome positioning

KW - axonal dystrophy

KW - autophagy

U2 - 10.1016/j.tcb.2018.08.002

DO - 10.1016/j.tcb.2018.08.002

M3 - Article

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SN - 0962-8924

VL - 28

SP - 761

EP - 763

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 10

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Lysosomes nor Mice Move Forward without Borcs7

Abstract

Keywords

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