Lung cancer risk in painters: Results from the SYNERGY pooled analysis

Neela Guha; Ann Olsson; Hans Kromhout; Roel Vermeulen; Thomas Brüning; Beate Pesch; Benjamin Kendzia; Heinz-Erich Wichmann; Irene Brüske; Isabelle Stücker; Sara De Matteis; Maria Teresa Landi; Neil Caporaso; Jack Siemiatycki; Per Gustavsson; Nils Plato; Franco Merletti; Dario Mirabelli; Lorenzo Richiardi; Wolfgang Ahrens; Hermann Pohlabeln; Karl-Heinz Jöckel; David Zaridze; Adrian Cassidy; Jolanta Lissowska; Neonila Szeszenia-Dabrowska; Simone Benhamou; Alena Slamova; Lenka Foretova; Vladimir Janout; Peter Rudnai; Eleonora Fabianova; Rodica Stanescu Dumitru; Francesco Forastiere; Bas Bueno-De-Mesquita; Susan Peters; Paolo Boffetta; Veronique Benhaim-Luzon; Kurt Straif

doi:10.1136/oemed-2011-100382.150

Lung cancer risk in painters: Results from the SYNERGY pooled analysis

Neela Guha, Ann Olsson, Hans Kromhout, Roel Vermeulen, Thomas Brüning, Beate Pesch, Benjamin Kendzia, Heinz-Erich Wichmann, Irene Brüske, Isabelle Stücker, Sara De Matteis, Maria Teresa Landi, Neil Caporaso, Jack Siemiatycki, Per Gustavsson, Nils Plato, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Wolfgang AhrensHermann Pohlabeln, Karl-Heinz Jöckel, David Zaridze, Adrian Cassidy, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Simone Benhamou, Alena Slamova, Lenka Foretova, Vladimir Janout, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Francesco Forastiere, Bas Bueno-De-Mesquita, Susan Peters, Paolo Boffetta, Veronique Benhaim-Luzon, Kurt Straif

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives The International Agency for Research on Cancer identified “occupational exposure as a painter” as a cause of lung cancer. Identifying the specific causative agent(s) has been difficult since painters are exposed to mixtures of known and suspected carcinogens that change over time. Using a large pooled dataset, we evaluated the risk of lung cancer among painters by duration of employment and painting activity. Methods Detailed individual data on smoking were available for 16258 lung cancer cases (605 painters, 3.7%) and 19922 ageand sex-matched controls (473 painters, 2.4%) from SYNERGY a pooled effort of 12 case-control studies in Europe and Canada. Painting activity was classified from job titles using ISCO 1968 and ISIC Revision 2 codes. Multivariable logistic regression models were adjusted for age, gender, centre, smoking habits and previous employment in high-risk occupations. Results An OR of 1.38 (95% CI 1.20 to 1.59) was found for ever working as a painter; the excess risk of lung cancer increased with increasing years of employment (p-trend

Original language	English
Pages (from-to)	46
Number of pages	1
Journal	Occupational and Environmental Medicine
Volume	68
DOIs	https://doi.org/10.1136/oemed-2011-100382.150
Publication status	Published - 1 Sept 2011

Keywords

carcinogen
epidemiology
human
painter
lung cancer
cancer risk
occupational health
risk
painting
employment
smoking
aerosol
international cooperation
neoplasm
occupational exposure
case control study
Europe
Canada
logistic regression analysis
work
model
gender
smoking habit
exposure
occupation

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Guha, N., Olsson, A., Kromhout, H., Vermeulen, R., Brüning, T., Pesch, B., Kendzia, B., Wichmann, H.-E., Brüske, I., Stücker, I., De Matteis, S., Landi, M. T., Caporaso, N., Siemiatycki, J., Gustavsson, P., Plato, N., Merletti, F., Mirabelli, D., Richiardi, L., ... Straif, K. (2011). Lung cancer risk in painters: Results from the SYNERGY pooled analysis. Occupational and Environmental Medicine, 68, 46. https://doi.org/10.1136/oemed-2011-100382.150

@article{dccc6ed53e964c25ac954ccf7f2fdd67,

title = "Lung cancer risk in painters: Results from the SYNERGY pooled analysis",

abstract = "Objectives The International Agency for Research on Cancer identified “occupational exposure as a painter” as a cause of lung cancer. Identifying the specific causative agent(s) has been difficult since painters are exposed to mixtures of known and suspected carcinogens that change over time. Using a large pooled dataset, we evaluated the risk of lung cancer among painters by duration of employment and painting activity. Methods Detailed individual data on smoking were available for 16258 lung cancer cases (605 painters, 3.7%) and 19922 ageand sex-matched controls (473 painters, 2.4%) from SYNERGY a pooled effort of 12 case-control studies in Europe and Canada. Painting activity was classified from job titles using ISCO 1968 and ISIC Revision 2 codes. Multivariable logistic regression models were adjusted for age, gender, centre, smoking habits and previous employment in high-risk occupations. Results An OR of 1.38 (95% CI 1.20 to 1.59) was found for ever working as a painter; the excess risk of lung cancer increased with increasing years of employment (p-trend",

keywords = "carcinogen, epidemiology, human, painter, lung cancer, cancer risk, occupational health, risk, painting, employment, smoking, aerosol, international cooperation, neoplasm, occupational exposure, case control study, Europe, Canada, logistic regression analysis, work, model, gender, smoking habit, exposure, occupation",

author = "Neela Guha and Ann Olsson and Hans Kromhout and Roel Vermeulen and Thomas Br{\"u}ning and Beate Pesch and Benjamin Kendzia and Heinz-Erich Wichmann and Irene Br{\"u}ske and Isabelle St{\"u}cker and {De Matteis}, Sara and Landi, {Maria Teresa} and Neil Caporaso and Jack Siemiatycki and Per Gustavsson and Nils Plato and Franco Merletti and Dario Mirabelli and Lorenzo Richiardi and Wolfgang Ahrens and Hermann Pohlabeln and Karl-Heinz J{\"o}ckel and David Zaridze and Adrian Cassidy and Jolanta Lissowska and Neonila Szeszenia-Dabrowska and Simone Benhamou and Alena Slamova and Lenka Foretova and Vladimir Janout and Peter Rudnai and Eleonora Fabianova and Dumitru, {Rodica Stanescu} and Francesco Forastiere and Bas Bueno-De-Mesquita and Susan Peters and Paolo Boffetta and Veronique Benhaim-Luzon and Kurt Straif",

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month = sep,

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doi = "10.1136/oemed-2011-100382.150",

language = "English",

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journal = "Occupational and Environmental Medicine",

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Guha, N, Olsson, A, Kromhout, H , Vermeulen, R, Brüning, T, Pesch, B, Kendzia, B, Wichmann, H-E, Brüske, I, Stücker, I, De Matteis, S, Landi, MT, Caporaso, N, Siemiatycki, J, Gustavsson, P, Plato, N, Merletti, F, Mirabelli, D, Richiardi, L, Ahrens, W, Pohlabeln, H, Jöckel, K-H, Zaridze, D, Cassidy, A, Lissowska, J, Szeszenia-Dabrowska, N, Benhamou, S, Slamova, A, Foretova, L, Janout, V, Rudnai, P, Fabianova, E, Dumitru, RS, Forastiere, F, Bueno-De-Mesquita, B, Peters, S, Boffetta, P, Benhaim-Luzon, V & Straif, K 2011, 'Lung cancer risk in painters: Results from the SYNERGY pooled analysis', Occupational and Environmental Medicine, vol. 68, pp. 46. https://doi.org/10.1136/oemed-2011-100382.150

TY - JOUR

T1 - Lung cancer risk in painters: Results from the SYNERGY pooled analysis

AU - Guha, Neela

AU - Olsson, Ann

AU - Kromhout, Hans

AU - Vermeulen, Roel

AU - Brüning, Thomas

AU - Pesch, Beate

AU - Kendzia, Benjamin

AU - Wichmann, Heinz-Erich

AU - Brüske, Irene

AU - Stücker, Isabelle

AU - De Matteis, Sara

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Siemiatycki, Jack

AU - Gustavsson, Per

AU - Plato, Nils

AU - Merletti, Franco

AU - Mirabelli, Dario

AU - Richiardi, Lorenzo

AU - Ahrens, Wolfgang

AU - Pohlabeln, Hermann

AU - Jöckel, Karl-Heinz

AU - Zaridze, David

AU - Cassidy, Adrian

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Benhamou, Simone

AU - Slamova, Alena

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Dumitru, Rodica Stanescu

AU - Forastiere, Francesco

AU - Bueno-De-Mesquita, Bas

AU - Peters, Susan

AU - Boffetta, Paolo

AU - Benhaim-Luzon, Veronique

AU - Straif, Kurt

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Objectives The International Agency for Research on Cancer identified “occupational exposure as a painter” as a cause of lung cancer. Identifying the specific causative agent(s) has been difficult since painters are exposed to mixtures of known and suspected carcinogens that change over time. Using a large pooled dataset, we evaluated the risk of lung cancer among painters by duration of employment and painting activity. Methods Detailed individual data on smoking were available for 16258 lung cancer cases (605 painters, 3.7%) and 19922 ageand sex-matched controls (473 painters, 2.4%) from SYNERGY a pooled effort of 12 case-control studies in Europe and Canada. Painting activity was classified from job titles using ISCO 1968 and ISIC Revision 2 codes. Multivariable logistic regression models were adjusted for age, gender, centre, smoking habits and previous employment in high-risk occupations. Results An OR of 1.38 (95% CI 1.20 to 1.59) was found for ever working as a painter; the excess risk of lung cancer increased with increasing years of employment (p-trend

AB - Objectives The International Agency for Research on Cancer identified “occupational exposure as a painter” as a cause of lung cancer. Identifying the specific causative agent(s) has been difficult since painters are exposed to mixtures of known and suspected carcinogens that change over time. Using a large pooled dataset, we evaluated the risk of lung cancer among painters by duration of employment and painting activity. Methods Detailed individual data on smoking were available for 16258 lung cancer cases (605 painters, 3.7%) and 19922 ageand sex-matched controls (473 painters, 2.4%) from SYNERGY a pooled effort of 12 case-control studies in Europe and Canada. Painting activity was classified from job titles using ISCO 1968 and ISIC Revision 2 codes. Multivariable logistic regression models were adjusted for age, gender, centre, smoking habits and previous employment in high-risk occupations. Results An OR of 1.38 (95% CI 1.20 to 1.59) was found for ever working as a painter; the excess risk of lung cancer increased with increasing years of employment (p-trend

KW - carcinogen

KW - epidemiology

KW - human

KW - painter

KW - lung cancer

KW - cancer risk

KW - occupational health

KW - risk

KW - painting

KW - employment

KW - smoking

KW - aerosol

KW - international cooperation

KW - neoplasm

KW - occupational exposure

KW - case control study

KW - Europe

KW - Canada

KW - logistic regression analysis

KW - work

KW - model

KW - gender

KW - smoking habit

KW - exposure

KW - occupation

U2 - 10.1136/oemed-2011-100382.150

DO - 10.1136/oemed-2011-100382.150

M3 - Article

SN - 1351-0711

VL - 68

SP - 46

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

ER -

Lung cancer risk in painters: Results from the SYNERGY pooled analysis

Abstract

Keywords

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