Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer

Dario Mirabelli; Franco Merletti; Lorenzo Richiardi; Marine Corbin; Iván Marín Franch; Ann Olsson; Per Gustavsson; Hans Kromhout; Susan Peters; Roel Vermeulen; Irene Brüske; Beate Pesch; Thomas Brüning; Isabelle Gross; Jack Siemiatycki; Javier Pintos; Heinz-Erich Wichmann; Dario Consonni; Nils Plato; Wolfgang Ahrens; Hermann Pohlabeln; Jolanta Lissowska; Neonila Szeszenia-Dabrowska; Adrian Cassidy; David Zaridze; Isabelle Stücker; Simone Benhamou; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Peter Rudnai; Eleonora Fabianova; Dana Mates; Bas Bueno-De-Mesquita; Paolo Boffetta; Kurt Straif

doi:10.1136/oemed-2011-100382.149

Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer

Dario Mirabelli
, Franco Merletti
, Lorenzo Richiardi
, Marine Corbin
, Iván Marín Franch
, Ann Olsson
, Per Gustavsson
, Hans Kromhout
, Susan Peters
, Roel Vermeulen
, Irene Brüske
, Beate Pesch
, Thomas Brüning
, Isabelle Gross
, Jack Siemiatycki
, Javier Pintos
, Heinz-Erich Wichmann
, Dario Consonni
, Nils Plato
, Wolfgang Ahrens

Hermann Pohlabeln, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Adrian Cassidy, David Zaridze, Isabelle Stücker, Simone Benhamou, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Peter Rudnai, Eleonora Fabianova, Dana Mates, Bas Bueno-De-Mesquita, Paolo Boffetta, Kurt Straif

University of Turin
Int Agcy Res Canc IARC WHO
Karolinska Institutet
Leibniz Institute for Prevention Research and Epidemiology
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
University of Montreal
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
Bremen Institute for Prevention Research and Social Medicine
M Sklodowska-Curie Cancer Center and Institute of Oncology
Nofer Institute of Occupational Medicine
University of Liverpool
Russian Cancer Research Centre
INSERM U 754 - IFR69
INSERM U 946
Charles University
Masaryk Memorial Cancer Institute
Palacky University
National Institute of Environment Health
Regional Authority of Public Health
Institut of Public Health
National Institute for Public Health and Environmental Protection
Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives Exploratory analyses by occupation or industry are commonly conducted in case-control studies. However cancer risks limited to certain jobs within an industry, or to a job within a given industry, become undetectable in the overall industry or job odds-ratio. Using the SYNERGY dataset we conducted an analysis based on occupations and industries combined. Methods Data included 10 917 male cases and 13 154 male controls. Industries and jobs were coded according to ISIC Revision 2 and ISCO 1968, respectively. Odds-ratios were computed for ISCO-ISIC combinations with ≥10 study subjects adjusting for study, age, and smoking. To allow for multiple comparisons we applied a semi-Bayes approach, shrinking towards a group mean the estimate for each ISCO-ISIC combination previously classified as: occupation known or suspected to entail lung cancer risk, other manual workers, other non-manual workers. Results Out of 1187 evaluated ISCO-ISIC combinations, 50 had an increased odds-ratio (p

Original language	English
Pages (from-to)	46
Number of pages	1
Journal	Occupational and Environmental Medicine
Volume	68
DOIs	https://doi.org/10.1136/oemed-2011-100382.149
Publication status	Published - 1 Sept 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

carcinogen
human
industry
cancer risk
lung cancer
male
case control study
occupation
occupational health
epidemiology
work
risk
worker
book
car
carpenter
building industry
painter
miner
welding
smoking

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10.1136/oemed-2011-100382.149

Cite this

Mirabelli, D., Merletti, F., Richiardi, L., Corbin, M., Franch, I. M., Olsson, A., Gustavsson, P., Kromhout, H., Peters, S., Vermeulen, R., Brüske, I., Pesch, B., Brüning, T., Gross, I., Siemiatycki, J., Pintos, J., Wichmann, H.-E., Consonni, D., Plato, N., ... Straif, K. (2011). Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer. Occupational and Environmental Medicine, 68, 46. https://doi.org/10.1136/oemed-2011-100382.149

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title = "Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer",

abstract = "Objectives Exploratory analyses by occupation or industry are commonly conducted in case-control studies. However cancer risks limited to certain jobs within an industry, or to a job within a given industry, become undetectable in the overall industry or job odds-ratio. Using the SYNERGY dataset we conducted an analysis based on occupations and industries combined. Methods Data included 10 917 male cases and 13 154 male controls. Industries and jobs were coded according to ISIC Revision 2 and ISCO 1968, respectively. Odds-ratios were computed for ISCO-ISIC combinations with ≥10 study subjects adjusting for study, age, and smoking. To allow for multiple comparisons we applied a semi-Bayes approach, shrinking towards a group mean the estimate for each ISCO-ISIC combination previously classified as: occupation known or suspected to entail lung cancer risk, other manual workers, other non-manual workers. Results Out of 1187 evaluated ISCO-ISIC combinations, 50 had an increased odds-ratio (p",

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author = "Dario Mirabelli and Franco Merletti and Lorenzo Richiardi and Marine Corbin and Franch, \{Iv{\'a}n Mar{\'i}n\} and Ann Olsson and Per Gustavsson and Hans Kromhout and Susan Peters and Roel Vermeulen and Irene Br{\"u}ske and Beate Pesch and Thomas Br{\"u}ning and Isabelle Gross and Jack Siemiatycki and Javier Pintos and Heinz-Erich Wichmann and Dario Consonni and Nils Plato and Wolfgang Ahrens and Hermann Pohlabeln and Jolanta Lissowska and Neonila Szeszenia-Dabrowska and Adrian Cassidy and David Zaridze and Isabelle St{\"u}cker and Simone Benhamou and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Peter Rudnai and Eleonora Fabianova and Dana Mates and Bas Bueno-De-Mesquita and Paolo Boffetta and Kurt Straif",

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day = "1",

doi = "10.1136/oemed-2011-100382.149",

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Mirabelli, D, Merletti, F, Richiardi, L, Corbin, M, Franch, IM, Olsson, A, Gustavsson, P, Kromhout, H , Peters, S , Vermeulen, R, Brüske, I, Pesch, B, Brüning, T, Gross, I, Siemiatycki, J, Pintos, J, Wichmann, H-E, Consonni, D, Plato, N, Ahrens, W, Pohlabeln, H, Lissowska, J, Szeszenia-Dabrowska, N, Cassidy, A, Zaridze, D, Stücker, I, Benhamou, S, Bencko, V, Foretova, L, Janout, V, Rudnai, P, Fabianova, E, Mates, D, Bueno-De-Mesquita, B, Boffetta, P & Straif, K 2011, 'Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer', Occupational and Environmental Medicine, vol. 68, pp. 46. https://doi.org/10.1136/oemed-2011-100382.149

Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer. / Mirabelli, Dario; Merletti, Franco; Richiardi, Lorenzo et al.
In: Occupational and Environmental Medicine, Vol. 68, 01.09.2011, p. 46.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer

AU - Mirabelli, Dario

AU - Merletti, Franco

AU - Richiardi, Lorenzo

AU - Corbin, Marine

AU - Franch, Iván Marín

AU - Olsson, Ann

AU - Gustavsson, Per

AU - Kromhout, Hans

AU - Peters, Susan

AU - Vermeulen, Roel

AU - Brüske, Irene

AU - Pesch, Beate

AU - Brüning, Thomas

AU - Gross, Isabelle

AU - Siemiatycki, Jack

AU - Pintos, Javier

AU - Wichmann, Heinz-Erich

AU - Consonni, Dario

AU - Plato, Nils

AU - Ahrens, Wolfgang

AU - Pohlabeln, Hermann

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Cassidy, Adrian

AU - Zaridze, David

AU - Stücker, Isabelle

AU - Benhamou, Simone

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Mates, Dana

AU - Bueno-De-Mesquita, Bas

AU - Boffetta, Paolo

AU - Straif, Kurt

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Objectives Exploratory analyses by occupation or industry are commonly conducted in case-control studies. However cancer risks limited to certain jobs within an industry, or to a job within a given industry, become undetectable in the overall industry or job odds-ratio. Using the SYNERGY dataset we conducted an analysis based on occupations and industries combined. Methods Data included 10 917 male cases and 13 154 male controls. Industries and jobs were coded according to ISIC Revision 2 and ISCO 1968, respectively. Odds-ratios were computed for ISCO-ISIC combinations with ≥10 study subjects adjusting for study, age, and smoking. To allow for multiple comparisons we applied a semi-Bayes approach, shrinking towards a group mean the estimate for each ISCO-ISIC combination previously classified as: occupation known or suspected to entail lung cancer risk, other manual workers, other non-manual workers. Results Out of 1187 evaluated ISCO-ISIC combinations, 50 had an increased odds-ratio (p

AB - Objectives Exploratory analyses by occupation or industry are commonly conducted in case-control studies. However cancer risks limited to certain jobs within an industry, or to a job within a given industry, become undetectable in the overall industry or job odds-ratio. Using the SYNERGY dataset we conducted an analysis based on occupations and industries combined. Methods Data included 10 917 male cases and 13 154 male controls. Industries and jobs were coded according to ISIC Revision 2 and ISCO 1968, respectively. Odds-ratios were computed for ISCO-ISIC combinations with ≥10 study subjects adjusting for study, age, and smoking. To allow for multiple comparisons we applied a semi-Bayes approach, shrinking towards a group mean the estimate for each ISCO-ISIC combination previously classified as: occupation known or suspected to entail lung cancer risk, other manual workers, other non-manual workers. Results Out of 1187 evaluated ISCO-ISIC combinations, 50 had an increased odds-ratio (p

KW - carcinogen

KW - human

KW - industry

KW - cancer risk

KW - lung cancer

KW - male

KW - case control study

KW - occupation

KW - occupational health

KW - epidemiology

KW - work

KW - risk

KW - worker

KW - book

KW - car

KW - carpenter

KW - building industry

KW - painter

KW - miner

KW - welding

KW - smoking

U2 - 10.1136/oemed-2011-100382.149

DO - 10.1136/oemed-2011-100382.149

M3 - Article

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VL - 68

SP - 46

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

ER -

Lung cancer risk among men by occupation and industry in SYNERGY - Pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer

Abstract

UN SDGs

Keywords

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