Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies

Dirk Taeger; Beate Pesch; Benjamin Kendzia; Thomas Behrens; Karl-Heinz Jöckel; Dirk Dahmann; Jack Siemiatycki; Hans Kromhout; Roel Vermeulen; Susan Peters; Ann Olsson; Irene Brüske; Heinz-Erich Wichmann; Isabelle Stücker; Florence Guida; Adonina Tardón; Franco Merletti; Dario Mirabelli; Lorenzo Richiardi; Hermann Pohlabeln; Wolfgang Ahrens; Maria Teresa Landi; Neil Caporaso; Angela Cecilia Pesatori; Anush Mukeriya; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Per Gustavsson; John Field; Michael W Marcus; Eleonora Fabianova; Andrea 't Mannetje; Neil Pearce; Peter Rudnai; Vladimir Bencko; Vladimir Janout; Rodica Stanescu Dumitru; Lenka Foretova; Francesco Forastiere; John McLaughlin John McLaughlin; Paul Demers Paul Demers; Bas Bueno-de-Mesquita Bas Bueno-de-Mesquita; Joachim Schüz Joachim Schüz; Kurt Straif Kurt Straif; Thomas Brüning

doi:10.5271/sjweh.3513

Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies

Dirk Taeger
, Beate Pesch
, Benjamin Kendzia
, Thomas Behrens
, Karl-Heinz Jöckel
, Dirk Dahmann
, Jack Siemiatycki
, Hans Kromhout
, Roel Vermeulen
, Susan Peters
, Ann Olsson
, Irene Brüske
, Heinz-Erich Wichmann
, Isabelle Stücker
, Florence Guida
, Adonina Tardón
, Franco Merletti
, Dario Mirabelli
, Lorenzo Richiardi
, Hermann Pohlabeln

Wolfgang Ahrens, Maria Teresa Landi, Neil Caporaso, Angela Cecilia Pesatori, Anush Mukeriya, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Per Gustavsson, John Field, Michael W Marcus, Eleonora Fabianova, Andrea 't Mannetje, Neil Pearce, Peter Rudnai, Vladimir Bencko, Vladimir Janout, Rodica Stanescu Dumitru, Lenka Foretova, Francesco Forastiere, John McLaughlin John McLaughlin, Paul Demers Paul Demers, Bas Bueno-de-Mesquita Bas Bueno-de-Mesquita, Joachim Schüz Joachim Schüz, Kurt Straif Kurt Straif, Thomas Brüning

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen.

METHODS: We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case-control study, controlling for smoking and employment in other at-risk occupations.

RESULTS: Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34-1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21-3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18-1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure.

CONCLUSIONS: This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

Original language	English
Pages (from-to)	467-477
Number of pages	11
Journal	Scandinavian Journal of Work, Environment & Health
Volume	41
Issue number	5
DOIs	https://doi.org/10.5271/sjweh.3513
Publication status	Published - 1 Sept 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.5271/sjweh.3513

467_477_taegerFinal published version, 359 KBLicence: Taverne

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Taeger, D., Pesch, B., Kendzia, B., Behrens, T., Jöckel, K.-H., Dahmann, D., Siemiatycki, J., Kromhout, H., Vermeulen, R., Peters, S., Olsson, A., Brüske, I., Wichmann, H.-E., Stücker, I., Guida, F., Tardón, A., Merletti, F., Mirabelli, D., Richiardi, L., ... Brüning, T. (2015). Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies. Scandinavian Journal of Work, Environment & Health, 41(5), 467-477. https://doi.org/10.5271/sjweh.3513

@article{428545cd5aaa4595a54d2397f1535a6c,

title = "Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies",

abstract = "OBJECTIVES: Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen.METHODS: We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case-control study, controlling for smoking and employment in other at-risk occupations.RESULTS: Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95\% confidence interval (95\% CI) 1.34-1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95\% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95\% CI 1.21-3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95\% CI 1.18-1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure.CONCLUSIONS: This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.",

author = "Dirk Taeger and Beate Pesch and Benjamin Kendzia and Thomas Behrens and Karl-Heinz J{\"o}ckel and Dirk Dahmann and Jack Siemiatycki and Hans Kromhout and Roel Vermeulen and Susan Peters and Ann Olsson and Irene Br{\"u}ske and Heinz-Erich Wichmann and Isabelle St{\"u}cker and Florence Guida and Adonina Tard{\'o}n and Franco Merletti and Dario Mirabelli and Lorenzo Richiardi and Hermann Pohlabeln and Wolfgang Ahrens and Landi, \{Maria Teresa\} and Neil Caporaso and Pesatori, \{Angela Cecilia\} and Anush Mukeriya and Neonila Szeszenia-Dabrowska and Jolanta Lissowska and Per Gustavsson and John Field and Marcus, \{Michael W\} and Eleonora Fabianova and \{'t Mannetje\}, Andrea and Neil Pearce and Peter Rudnai and Vladimir Bencko and Vladimir Janout and Dumitru, \{Rodica Stanescu\} and Lenka Foretova and Francesco Forastiere and \{John McLaughlin\}, \{John McLaughlin\} and \{Paul Demers\}, \{Paul Demers\} and \{Bas Bueno-de-Mesquita\}, \{Bas Bueno-de-Mesquita\} and \{Joachim Sch{\"u}z\}, \{Joachim Sch{\"u}z\} and \{Kurt Straif\}, \{Kurt Straif\} and Thomas Br{\"u}ning",

year = "2015",

month = sep,

day = "1",

doi = "10.5271/sjweh.3513",

language = "English",

volume = "41",

pages = "467--477",

journal = "Scandinavian Journal of Work, Environment \& Health",

issn = "0355-3140",

publisher = "Nordic Association of Occupational Safety and Health",

number = "5",

}

Taeger, D, Pesch, B, Kendzia, B, Behrens, T, Jöckel, K-H, Dahmann, D, Siemiatycki, J, Kromhout, H , Vermeulen, R , Peters, S, Olsson, A, Brüske, I, Wichmann, H-E, Stücker, I, Guida, F, Tardón, A, Merletti, F, Mirabelli, D, Richiardi, L, Pohlabeln, H, Ahrens, W, Landi, MT, Caporaso, N, Pesatori, AC, Mukeriya, A, Szeszenia-Dabrowska, N, Lissowska, J, Gustavsson, P, Field, J, Marcus, MW, Fabianova, E, 't Mannetje, A, Pearce, N, Rudnai, P, Bencko, V, Janout, V, Dumitru, RS, Foretova, L, Forastiere, F, John McLaughlin, JM, Paul Demers, PD, Bas Bueno-de-Mesquita, BB-M, Joachim Schüz, JS, Kurt Straif, KS & Brüning, T 2015, 'Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies', Scandinavian Journal of Work, Environment & Health, vol. 41, no. 5, pp. 467-477. https://doi.org/10.5271/sjweh.3513

Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies. / Taeger, Dirk; Pesch, Beate; Kendzia, Benjamin et al.
In: Scandinavian Journal of Work, Environment & Health, Vol. 41, No. 5, 01.09.2015, p. 467-477.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Lung cancer among coal miners, ore miners and quarrymen

T2 - smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies

AU - Taeger, Dirk

AU - Pesch, Beate

AU - Kendzia, Benjamin

AU - Behrens, Thomas

AU - Jöckel, Karl-Heinz

AU - Dahmann, Dirk

AU - Siemiatycki, Jack

AU - Kromhout, Hans

AU - Vermeulen, Roel

AU - Peters, Susan

AU - Olsson, Ann

AU - Brüske, Irene

AU - Wichmann, Heinz-Erich

AU - Stücker, Isabelle

AU - Guida, Florence

AU - Tardón, Adonina

AU - Merletti, Franco

AU - Mirabelli, Dario

AU - Richiardi, Lorenzo

AU - Pohlabeln, Hermann

AU - Ahrens, Wolfgang

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Pesatori, Angela Cecilia

AU - Mukeriya, Anush

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Gustavsson, Per

AU - Field, John

AU - Marcus, Michael W

AU - Fabianova, Eleonora

AU - 't Mannetje, Andrea

AU - Pearce, Neil

AU - Rudnai, Peter

AU - Bencko, Vladimir

AU - Janout, Vladimir

AU - Dumitru, Rodica Stanescu

AU - Foretova, Lenka

AU - Forastiere, Francesco

AU - John McLaughlin, John McLaughlin

AU - Paul Demers, Paul Demers

AU - Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita

AU - Joachim Schüz, Joachim Schüz

AU - Kurt Straif, Kurt Straif

AU - Brüning, Thomas

PY - 2015/9/1

Y1 - 2015/9/1

N2 - OBJECTIVES: Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen.METHODS: We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case-control study, controlling for smoking and employment in other at-risk occupations.RESULTS: Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34-1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21-3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18-1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure.CONCLUSIONS: This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

AB - OBJECTIVES: Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen.METHODS: We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case-control study, controlling for smoking and employment in other at-risk occupations.RESULTS: Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34-1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21-3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18-1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure.CONCLUSIONS: This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

U2 - 10.5271/sjweh.3513

DO - 10.5271/sjweh.3513

M3 - Article

C2 - 26153779

SN - 0355-3140

VL - 41

SP - 467

EP - 477

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

IS - 5

ER -

Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies

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