Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets

Mathilde Richard; Sander Herfst; Judith M A van den Brand; Pascal Lexmond; Theo M Bestebroer; Guus F Rimmelzwaan; Marion P G Koopmans; Thijs Kuiken; Ron A M Fouchier

doi:10.1371/journal.pone.0129827

Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets

Mathilde Richard, Sander Herfst, Judith M A van den Brand, Pascal Lexmond, Theo M Bestebroer, Guus F Rimmelzwaan, Marion P G Koopmans, Thijs Kuiken, Ron A M Fouchier

Department of Viroscience, Postgraduate School Molecular Medicine, Erasmus MC, Rotterdam, The Netherlands.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Highly pathogenic avian influenza (HPAI) H5N8 viruses that emerged in poultry in East Asia spread to Europe and North America by late 2014. Here we show that the European HPAI H5N8 viruses differ from the Korean and Japanese HPAI H5N8 viruses by several amino acids and that a Dutch HPAI H5N8 virus had low virulence and was not transmitted via the airborne route in ferrets. The virus did not cross-react with sera raised against pre-pandemic H5 vaccine strains. This data is useful for public health risk assessments.

Original language	English
Pages (from-to)	e0129827
Journal	PLoS One
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0129827
Publication status	Published - 2015
Externally published	Yes

Keywords

Amino Acid Substitution
Animals
Chickens
Dogs
Europe
Far East
Ferrets
Genes, Viral
Influenza A virus
Influenza in Birds
Madin Darby Canine Kidney Cells
Mutation
Orthomyxoviridae Infections
Viral Load
Virulence
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0129827

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title = "Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets",

abstract = "Highly pathogenic avian influenza (HPAI) H5N8 viruses that emerged in poultry in East Asia spread to Europe and North America by late 2014. Here we show that the European HPAI H5N8 viruses differ from the Korean and Japanese HPAI H5N8 viruses by several amino acids and that a Dutch HPAI H5N8 virus had low virulence and was not transmitted via the airborne route in ferrets. The virus did not cross-react with sera raised against pre-pandemic H5 vaccine strains. This data is useful for public health risk assessments.",

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author = "Mathilde Richard and Sander Herfst and {van den Brand}, {Judith M A} and Pascal Lexmond and Bestebroer, {Theo M} and Rimmelzwaan, {Guus F} and Koopmans, {Marion P G} and Thijs Kuiken and Fouchier, {Ron A M}",

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doi = "10.1371/journal.pone.0129827",

language = "English",

volume = "10",

pages = "e0129827",

journal = "PLoS One",

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TY - JOUR

T1 - Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets

AU - Richard, Mathilde

AU - Herfst, Sander

AU - van den Brand, Judith M A

AU - Lexmond, Pascal

AU - Bestebroer, Theo M

AU - Rimmelzwaan, Guus F

AU - Koopmans, Marion P G

AU - Kuiken, Thijs

AU - Fouchier, Ron A M

PY - 2015

Y1 - 2015

N2 - Highly pathogenic avian influenza (HPAI) H5N8 viruses that emerged in poultry in East Asia spread to Europe and North America by late 2014. Here we show that the European HPAI H5N8 viruses differ from the Korean and Japanese HPAI H5N8 viruses by several amino acids and that a Dutch HPAI H5N8 virus had low virulence and was not transmitted via the airborne route in ferrets. The virus did not cross-react with sera raised against pre-pandemic H5 vaccine strains. This data is useful for public health risk assessments.

AB - Highly pathogenic avian influenza (HPAI) H5N8 viruses that emerged in poultry in East Asia spread to Europe and North America by late 2014. Here we show that the European HPAI H5N8 viruses differ from the Korean and Japanese HPAI H5N8 viruses by several amino acids and that a Dutch HPAI H5N8 virus had low virulence and was not transmitted via the airborne route in ferrets. The virus did not cross-react with sera raised against pre-pandemic H5 vaccine strains. This data is useful for public health risk assessments.

KW - Amino Acid Substitution

KW - Animals

KW - Chickens

KW - Dogs

KW - Europe

KW - Far East

KW - Ferrets

KW - Genes, Viral

KW - Influenza A virus

KW - Influenza in Birds

KW - Madin Darby Canine Kidney Cells

KW - Mutation

KW - Orthomyxoviridae Infections

KW - Viral Load

KW - Virulence

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0129827

DO - 10.1371/journal.pone.0129827

M3 - Article

C2 - 26090682

SN - 1932-6203

VL - 10

SP - e0129827

JO - PLoS One

JF - PLoS One

IS - 6

ER -

Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets

Abstract

Keywords

UN SDGs

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