Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects

Meng Wang; Rob Beelen; Massimo Stafoggia; Ole Raaschou-Nielsen; Zorana Jovanovic Andersen; Barbara Hoffmann; Paul Fischer; Danny Houthuijs; Mark Nieuwenhuijsen; Gudrun Weinmayr; Paolo Vineis; Wei W. Xun; Konstantina Dimakopoulou; Evangelia Samoli; Tiina Laatikainen; Timo Lanki; Anu W. Turunen; Bente Oftedal; Per Schwarze; Geir Aamodt; Johanna Penell; Ulf De Faire; Michal Korek; Karin Leander; Goran Pershagen; Nancy L. Pedersen; Claes-Goran Ostenson; Laura Fratiglioni; Kirsten Thorup Eriksen; Mette Sorensen; Anne Tjonneland; Bas Bueno-de-Mesquita; Marloes Eeftens; Michiel L. Bots; Kees Meliefste; Ursula Kraemer; Joachim Heinrich; Dorothea Sugiri; Timothy Key; Kees de Hoogh; Kathrin Wolf; Annette Peters; Josef Cyrys; Andrea Jaensch; Hans Concin; Gabriele Nagel; Ming-Yi Tsai; Harish Phuleria; Alex Ineichen; Nino Kuenzli; Nicole Probst-Hensch; Emmanuel Schaffner; Alice Vilier; Francoise Clavel-Chapelon; Christophe Declerq; Fulvio Ricceri; Carlotta Sacerdote; Alessandro Marcon; Claudia Galassi; Enrica Migliore; Andrea Ranzi; Giulia Cesaroni; Chiara Badaloni; Francesco Forastiere; Michail Katsoulis; Antonia Trichopoulou; Menno Keuken; Aleksandra Jedynska; Ingeborg M. Kooter; Jaakko Kukkonen; Ranjeet S. Sokhi; Bert Brunekreef; Klea Katsouyanni; Gerard Hoek

doi:10.1016/j.envint.2014.01.026

Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects

Meng Wang^*, Rob Beelen, Massimo Stafoggia, Ole Raaschou-Nielsen, Zorana Jovanovic Andersen, Barbara Hoffmann, Paul Fischer, Danny Houthuijs, Mark Nieuwenhuijsen, Gudrun Weinmayr, Paolo Vineis, Wei W. Xun, Konstantina Dimakopoulou, Evangelia Samoli, Tiina Laatikainen, Timo Lanki, Anu W. Turunen, Bente Oftedal, Per Schwarze, Geir AamodtJohanna Penell, Ulf De Faire, Michal Korek, Karin Leander, Goran Pershagen, Nancy L. Pedersen, Claes-Goran Ostenson, Laura Fratiglioni, Kirsten Thorup Eriksen, Mette Sorensen, Anne Tjonneland, Bas Bueno-de-Mesquita, Marloes Eeftens, Michiel L. Bots, Kees Meliefste, Ursula Kraemer, Joachim Heinrich, Dorothea Sugiri, Timothy Key, Kees de Hoogh, Kathrin Wolf, Annette Peters, Josef Cyrys, Andrea Jaensch, Hans Concin, Gabriele Nagel, Ming-Yi Tsai, Harish Phuleria, Alex Ineichen, Nino Kuenzli, Nicole Probst-Hensch, Emmanuel Schaffner, Alice Vilier, Francoise Clavel-Chapelon, Christophe Declerq, Fulvio Ricceri, Carlotta Sacerdote, Alessandro Marcon, Claudia Galassi, Enrica Migliore, Andrea Ranzi, Giulia Cesaroni, Chiara Badaloni, Francesco Forastiere, Michail Katsoulis, Antonia Trichopoulou, Menno Keuken, Aleksandra Jedynska, Ingeborg M. Kooter, Jaakko Kukkonen, Ranjeet S. Sokhi, Bert Brunekreef, Klea Katsouyanni, Gerard Hoek

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only.

Aims: The aim of this study was to examine the association of PM composition with cardiovascular mortality.

Methods: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10 pm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects metaanalysis was used to calculate combined effect estimates.

Results: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% Cl: 0.93-1.47), and S in PM2.5 (1.08,95% Cl: 0.95-1.22) and PM10 (1.09,95% Cl: 0.90-132).

Conclusion: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality. (C) 2014 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	97-106
Number of pages	10
Journal	Environment international
Volume	66
DOIs	https://doi.org/10.1016/j.envint.2014.01.026
Publication status	Published - May 2014

Funding

~ The research leading to these results has received funding from the European Community's Seventh Framework Program (FP7/2007-2011): ESCAPE 3 (grant agreement number: 211250) and TRANSPHORM (ENV.2009.12.2.1). SAPALDIA received support in mortality record linkage from the Swiss National Cohort Study, grant numbers: Periode 1.7.2006-30.6.2011:108806, Periode 1.7.2011-30.6.2014: 134273. The KORA research platform and the MONICA Augsburg studies were initiated and financed by the Helmholtz Zentrum Munchen, German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. We thank Marjan Tewis, Marieke Oldenwening, Marta Cirach, Audrey de Nazelle, Marianne Rutschi, Gregor Fessler, Alwin Muxel, Bernhard Anwander, Paolo Crosignani, Jon Wickmann, Daniela Raffaele, Marco Gilardetti, Thomas Kuhlbusch, Ulrich Quass,

Keywords

Long-term exposure
Particulate matter
Constituents
Cardiovascular mortality
ESCAPE
TRANSPHORM
USE REGRESSION-MODELS
EXTENDED FOLLOW-UP
HARVARD 6 CITIES
AIR-POLLUTION
CHEMICAL-COMPOSITION
TIME-SERIES
MOUSE LUNG
NO2
DISEASE
PARTICLES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.envint.2014.01.026

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Cite this

Wang, M., Beelen, R., Stafoggia, M., Raaschou-Nielsen, O., Andersen, Z. J., Hoffmann, B., Fischer, P., Houthuijs, D., Nieuwenhuijsen, M., Weinmayr, G., Vineis, P., Xun, W. W., Dimakopoulou, K., Samoli, E., Laatikainen, T., Lanki, T., Turunen, A. W., Oftedal, B., Schwarze, P., ... Hoek, G. (2014). Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environment international, 66, 97-106. https://doi.org/10.1016/j.envint.2014.01.026

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title = "Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects",

abstract = "Background: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only.Aims: The aim of this study was to examine the association of PM composition with cardiovascular mortality.Methods: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10 pm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects metaanalysis was used to calculate combined effect estimates.Results: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% Cl: 0.93-1.47), and S in PM2.5 (1.08,95% Cl: 0.95-1.22) and PM10 (1.09,95% Cl: 0.90-132).Conclusion: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality. (C) 2014 Elsevier Ltd. All rights reserved.",

keywords = "Long-term exposure, Particulate matter, Constituents, Cardiovascular mortality, ESCAPE, TRANSPHORM, USE REGRESSION-MODELS, EXTENDED FOLLOW-UP, HARVARD 6 CITIES, AIR-POLLUTION, CHEMICAL-COMPOSITION, TIME-SERIES, MOUSE LUNG, NO2, DISEASE, PARTICLES",

author = "Meng Wang and Rob Beelen and Massimo Stafoggia and Ole Raaschou-Nielsen and Andersen, {Zorana Jovanovic} and Barbara Hoffmann and Paul Fischer and Danny Houthuijs and Mark Nieuwenhuijsen and Gudrun Weinmayr and Paolo Vineis and Xun, {Wei W.} and Konstantina Dimakopoulou and Evangelia Samoli and Tiina Laatikainen and Timo Lanki and Turunen, {Anu W.} and Bente Oftedal and Per Schwarze and Geir Aamodt and Johanna Penell and {De Faire}, Ulf and Michal Korek and Karin Leander and Goran Pershagen and Pedersen, {Nancy L.} and Claes-Goran Ostenson and Laura Fratiglioni and Eriksen, {Kirsten Thorup} and Mette Sorensen and Anne Tjonneland and Bas Bueno-de-Mesquita and Marloes Eeftens and Bots, {Michiel L.} and Kees Meliefste and Ursula Kraemer and Joachim Heinrich and Dorothea Sugiri and Timothy Key and {de Hoogh}, Kees and Kathrin Wolf and Annette Peters and Josef Cyrys and Andrea Jaensch and Hans Concin and Gabriele Nagel and Ming-Yi Tsai and Harish Phuleria and Alex Ineichen and Nino Kuenzli and Nicole Probst-Hensch and Emmanuel Schaffner and Alice Vilier and Francoise Clavel-Chapelon and Christophe Declerq and Fulvio Ricceri and Carlotta Sacerdote and Alessandro Marcon and Claudia Galassi and Enrica Migliore and Andrea Ranzi and Giulia Cesaroni and Chiara Badaloni and Francesco Forastiere and Michail Katsoulis and Antonia Trichopoulou and Menno Keuken and Aleksandra Jedynska and Kooter, {Ingeborg M.} and Jaakko Kukkonen and Sokhi, {Ranjeet S.} and Bert Brunekreef and Klea Katsouyanni and Gerard Hoek",

year = "2014",

month = may,

doi = "10.1016/j.envint.2014.01.026",

language = "English",

volume = "66",

pages = "97--106",

journal = "Environment international",

issn = "0160-4120",

publisher = "Elsevier Limited",

}

Wang, M, Beelen, R, Stafoggia, M, Raaschou-Nielsen, O, Andersen, ZJ, Hoffmann, B, Fischer, P, Houthuijs, D, Nieuwenhuijsen, M, Weinmayr, G, Vineis, P, Xun, WW, Dimakopoulou, K, Samoli, E, Laatikainen, T, Lanki, T, Turunen, AW, Oftedal, B, Schwarze, P, Aamodt, G, Penell, J, De Faire, U, Korek, M, Leander, K, Pershagen, G, Pedersen, NL, Ostenson, C-G, Fratiglioni, L, Eriksen, KT, Sorensen, M, Tjonneland, A, Bueno-de-Mesquita, B, Eeftens, M, Bots, ML, Meliefste, K, Kraemer, U, Heinrich, J, Sugiri, D, Key, T, de Hoogh, K, Wolf, K, Peters, A, Cyrys, J, Jaensch, A, Concin, H, Nagel, G, Tsai, M-Y, Phuleria, H, Ineichen, A, Kuenzli, N, Probst-Hensch, N, Schaffner, E, Vilier, A, Clavel-Chapelon, F, Declerq, C, Ricceri, F, Sacerdote, C, Marcon, A, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Katsoulis, M, Trichopoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Sokhi, RS, Brunekreef, B, Katsouyanni, K & Hoek, G 2014, 'Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects', Environment international, vol. 66, pp. 97-106. https://doi.org/10.1016/j.envint.2014.01.026

TY - JOUR

T1 - Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts

T2 - Results from the ESCAPE and TRANSPHORM projects

AU - Wang, Meng

AU - Beelen, Rob

AU - Stafoggia, Massimo

AU - Raaschou-Nielsen, Ole

AU - Andersen, Zorana Jovanovic

AU - Hoffmann, Barbara

AU - Fischer, Paul

AU - Houthuijs, Danny

AU - Nieuwenhuijsen, Mark

AU - Weinmayr, Gudrun

AU - Vineis, Paolo

AU - Xun, Wei W.

AU - Dimakopoulou, Konstantina

AU - Samoli, Evangelia

AU - Laatikainen, Tiina

AU - Lanki, Timo

AU - Turunen, Anu W.

AU - Oftedal, Bente

AU - Schwarze, Per

AU - Aamodt, Geir

AU - Penell, Johanna

AU - De Faire, Ulf

AU - Korek, Michal

AU - Leander, Karin

AU - Pershagen, Goran

AU - Pedersen, Nancy L.

AU - Ostenson, Claes-Goran

AU - Fratiglioni, Laura

AU - Eriksen, Kirsten Thorup

AU - Sorensen, Mette

AU - Tjonneland, Anne

AU - Bueno-de-Mesquita, Bas

AU - Eeftens, Marloes

AU - Bots, Michiel L.

AU - Meliefste, Kees

AU - Kraemer, Ursula

AU - Heinrich, Joachim

AU - Sugiri, Dorothea

AU - Key, Timothy

AU - de Hoogh, Kees

AU - Wolf, Kathrin

AU - Peters, Annette

AU - Cyrys, Josef

AU - Jaensch, Andrea

AU - Concin, Hans

AU - Nagel, Gabriele

AU - Tsai, Ming-Yi

AU - Phuleria, Harish

AU - Ineichen, Alex

AU - Kuenzli, Nino

AU - Probst-Hensch, Nicole

AU - Schaffner, Emmanuel

AU - Vilier, Alice

AU - Clavel-Chapelon, Francoise

AU - Declerq, Christophe

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Marcon, Alessandro

AU - Galassi, Claudia

AU - Migliore, Enrica

AU - Ranzi, Andrea

AU - Cesaroni, Giulia

AU - Badaloni, Chiara

AU - Forastiere, Francesco

AU - Katsoulis, Michail

AU - Trichopoulou, Antonia

AU - Keuken, Menno

AU - Jedynska, Aleksandra

AU - Kooter, Ingeborg M.

AU - Kukkonen, Jaakko

AU - Sokhi, Ranjeet S.

AU - Brunekreef, Bert

AU - Katsouyanni, Klea

AU - Hoek, Gerard

PY - 2014/5

Y1 - 2014/5

N2 - Background: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only.Aims: The aim of this study was to examine the association of PM composition with cardiovascular mortality.Methods: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10 pm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects metaanalysis was used to calculate combined effect estimates.Results: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% Cl: 0.93-1.47), and S in PM2.5 (1.08,95% Cl: 0.95-1.22) and PM10 (1.09,95% Cl: 0.90-132).Conclusion: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality. (C) 2014 Elsevier Ltd. All rights reserved.

AB - Background: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only.Aims: The aim of this study was to examine the association of PM composition with cardiovascular mortality.Methods: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10 pm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects metaanalysis was used to calculate combined effect estimates.Results: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% Cl: 0.93-1.47), and S in PM2.5 (1.08,95% Cl: 0.95-1.22) and PM10 (1.09,95% Cl: 0.90-132).Conclusion: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality. (C) 2014 Elsevier Ltd. All rights reserved.

KW - Long-term exposure

KW - Particulate matter

KW - Constituents

KW - Cardiovascular mortality

KW - ESCAPE

KW - TRANSPHORM

KW - USE REGRESSION-MODELS

KW - EXTENDED FOLLOW-UP

KW - HARVARD 6 CITIES

KW - AIR-POLLUTION

KW - CHEMICAL-COMPOSITION

KW - TIME-SERIES

KW - MOUSE LUNG

KW - NO2

KW - DISEASE

KW - PARTICLES

U2 - 10.1016/j.envint.2014.01.026

DO - 10.1016/j.envint.2014.01.026

M3 - Article

SN - 0160-4120

VL - 66

SP - 97

EP - 106

JO - Environment international

JF - Environment international

ER -

Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects

Abstract

Funding

Keywords

UN SDGs

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