Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

Zorana J. Andersen; Massimo Stafoggia; Gudrun Weinmayr; Marie Pedersen; Claudia Galassi; Jeanette T Jørgensen; Anna Oudin; Bertil Forsberg; David Olsson; Bente Oftedal; Gunn Marit Aasvang; Geir Aamodt; Andrei Pyko; Göran Pershagen; Michal Korek; Ulf de Faire; Nancy L. Pedersen; Claes Göran Östenson; Laura Fratiglioni; Kirsten T. Eriksen; Anne Tjønneland; Petra H. Peeters; H. Bas Bueno-de-Mesquita; Michelle Plusquin; Timothy J. Key; Andrea Jaensch; Gabriele Nagel; Alois Lang; Meng Wang; Ming-Yi Tsai; Agnes Fournier; Marie Christine Boutron-Ruault; Laura Baglietto; Sara Grioni; Alessandro Marcon; Vittorio Krogh; Fulvio Ricceri; Carlotta Sacerdote; Enrica Migliore; Ibon Tamayo-Uria; Pilar Amiano; Miren Dorronsoro; Roel Vermeulen; Rajneet Sokhi; Menno Keuken; Kees de Hoogh; Rob Beelen; Paolo Vineis; Giulia Cesaroni; Bert Brunekreef; Gerard Hoek; Ole Raaschou-Nielsen

doi:10.1289/EHP1742

Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

Zorana J. Andersen, Massimo Stafoggia, Gudrun Weinmayr, Marie Pedersen, Claudia Galassi, Jeanette T Jørgensen, Anna Oudin, Bertil Forsberg, David Olsson, Bente Oftedal, Gunn Marit Aasvang, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf de Faire, Nancy L. Pedersen, Claes Göran Östenson, Laura Fratiglioni, Kirsten T. EriksenAnne Tjønneland, Petra H. Peeters, H. Bas Bueno-de-Mesquita, Michelle Plusquin, Timothy J. Key, Andrea Jaensch, Gabriele Nagel, Alois Lang, Meng Wang, Ming-Yi Tsai, Agnes Fournier, Marie Christine Boutron-Ruault, Laura Baglietto, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Enrica Migliore, Ibon Tamayo-Uria, Pilar Amiano, Miren Dorronsoro, Roel Vermeulen, Rajneet Sokhi, Menno Keuken, Kees de Hoogh, Rob Beelen, Paolo Vineis, Giulia Cesaroni, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.

OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.

METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.

RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].

CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https://doi.org/10.1289/EHP1742.

Original language	English
Article number	107005
Journal	Environmental Health Perspectives
Volume	125
Issue number	10
DOIs	https://doi.org/10.1289/EHP1742
Publication status	Published - 13 Oct 2017

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Andersen, Z. J., Stafoggia, M., Weinmayr, G., Pedersen, M., Galassi, C., Jørgensen, J. T., Oudin, A., Forsberg, B., Olsson, D., Oftedal, B., Marit Aasvang, G., Aamodt, G., Pyko, A., Pershagen, G., Korek, M., de Faire, U., Pedersen, N. L., Östenson, C. G., Fratiglioni, L., ... Raaschou-Nielsen, O. (2017). Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. Environmental Health Perspectives, 125(10), Article 107005. https://doi.org/10.1289/EHP1742

@article{88819b20a2394ba7996a9ee77aab4bb8,

title = "Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project",

abstract = "BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https://doi.org/10.1289/EHP1742.",

author = "Andersen, {Zorana J.} and Massimo Stafoggia and Gudrun Weinmayr and Marie Pedersen and Claudia Galassi and J{\o}rgensen, {Jeanette T} and Anna Oudin and Bertil Forsberg and David Olsson and Bente Oftedal and {Marit Aasvang}, Gunn and Geir Aamodt and Andrei Pyko and G{\"o}ran Pershagen and Michal Korek and {de Faire}, Ulf and Pedersen, {Nancy L.} and {\"O}stenson, {Claes G{\"o}ran} and Laura Fratiglioni and Eriksen, {Kirsten T.} and Anne Tj{\o}nneland and Peeters, {Petra H.} and Bueno-de-Mesquita, {H. Bas} and Michelle Plusquin and Key, {Timothy J.} and Andrea Jaensch and Gabriele Nagel and Alois Lang and Meng Wang and Ming-Yi Tsai and Agnes Fournier and Boutron-Ruault, {Marie Christine} and Laura Baglietto and Sara Grioni and Alessandro Marcon and Vittorio Krogh and Fulvio Ricceri and Carlotta Sacerdote and Enrica Migliore and Ibon Tamayo-Uria and Pilar Amiano and Miren Dorronsoro and Roel Vermeulen and Rajneet Sokhi and Menno Keuken and {de Hoogh}, Kees and Rob Beelen and Paolo Vineis and Giulia Cesaroni and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen",

year = "2017",

month = oct,

day = "13",

doi = "10.1289/EHP1742",

language = "English",

volume = "125",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "Public Health Services, US Dept of Health and Human Services",

number = "10",

}

Andersen, ZJ, Stafoggia, M, Weinmayr, G, Pedersen, M, Galassi, C, Jørgensen, JT, Oudin, A, Forsberg, B, Olsson, D, Oftedal, B, Marit Aasvang, G, Aamodt, G, Pyko, A, Pershagen, G, Korek, M, de Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Eriksen, KT, Tjønneland, A, Peeters, PH, Bueno-de-Mesquita, HB, Plusquin, M, Key, TJ, Jaensch, A, Nagel, G, Lang, A, Wang, M, Tsai, M-Y, Fournier, A, Boutron-Ruault, MC, Baglietto, L, Grioni, S, Marcon, A, Krogh, V, Ricceri, F, Sacerdote, C, Migliore, E, Tamayo-Uria, I, Amiano, P, Dorronsoro, M, Vermeulen, R, Sokhi, R, Keuken, M, de Hoogh, K, Beelen, R, Vineis, P, Cesaroni, G, Brunekreef, B , Hoek, G & Raaschou-Nielsen, O 2017, 'Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project', Environmental Health Perspectives, vol. 125, no. 10, 107005. https://doi.org/10.1289/EHP1742

TY - JOUR

T1 - Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

AU - Andersen, Zorana J.

AU - Stafoggia, Massimo

AU - Weinmayr, Gudrun

AU - Pedersen, Marie

AU - Galassi, Claudia

AU - Jørgensen, Jeanette T

AU - Oudin, Anna

AU - Forsberg, Bertil

AU - Olsson, David

AU - Oftedal, Bente

AU - Marit Aasvang, Gunn

AU - Aamodt, Geir

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - de Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes Göran

AU - Fratiglioni, Laura

AU - Eriksen, Kirsten T.

AU - Tjønneland, Anne

AU - Peeters, Petra H.

AU - Bueno-de-Mesquita, H. Bas

AU - Plusquin, Michelle

AU - Key, Timothy J.

AU - Jaensch, Andrea

AU - Nagel, Gabriele

AU - Lang, Alois

AU - Wang, Meng

AU - Tsai, Ming-Yi

AU - Fournier, Agnes

AU - Boutron-Ruault, Marie Christine

AU - Baglietto, Laura

AU - Grioni, Sara

AU - Marcon, Alessandro

AU - Krogh, Vittorio

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Migliore, Enrica

AU - Tamayo-Uria, Ibon

AU - Amiano, Pilar

AU - Dorronsoro, Miren

AU - Vermeulen, Roel

AU - Sokhi, Rajneet

AU - Keuken, Menno

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Vineis, Paolo

AU - Cesaroni, Giulia

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

PY - 2017/10/13

Y1 - 2017/10/13

N2 - BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https://doi.org/10.1289/EHP1742.

AB - BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https://doi.org/10.1289/EHP1742.

U2 - 10.1289/EHP1742

DO - 10.1289/EHP1742

M3 - Article

C2 - 29033383

SN - 0091-6765

VL - 125

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 10

M1 - 107005

ER -

Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

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