Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

J Chen; S Rodopoulou; M Strak; K de Hoogh; T Taj; AH Poulsen; ZJ Andersen; T Bellander; J Brandt; E Zitt; D Fecht; F Forastiere; J Gulliver; O Hertel; B Hoffmann; UA Hvidtfeldt; WMM Verschuren; JT Jorgensen; K Katsouyanni; M Ketzel; A Lager; K Leander; S Liu; P Ljungman; G Severi; MC Boutron-Ruault; PKE Magnusson; G Nagel; G Pershagen; A Peters; D Rizzuto; YT van der Schouw; E Samoli; M Sorensen; M Stafoggia; A Tjonneland; G Weinmayr; K Wolf; B Brunekreef; O Raaschou-Nielsen; G Hoek

doi:10.1038/s41416-022-01735-4

Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

J Chen^*
, S Rodopoulou
, M Strak
, K de Hoogh
, T Taj
, AH Poulsen
, ZJ Andersen
, T Bellander
, J Brandt
, E Zitt
, D Fecht
, F Forastiere
, J Gulliver
, O Hertel
, B Hoffmann
, UA Hvidtfeldt
, WMM Verschuren
, JT Jorgensen
, K Katsouyanni
, M Ketzel

A Lager, K Leander, S Liu, P Ljungman, G Severi, MC Boutron-Ruault, PKE Magnusson, G Nagel, G Pershagen, A Peters, D Rizzuto, YT van der Schouw, E Samoli, M Sorensen, M Stafoggia, A Tjonneland, G Weinmayr, K Wolf, B Brunekreef, O Raaschou-Nielsen, G Hoek

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background
The evidence linking ambient air pollution to bladder cancer is limited and mixed.

Methods
We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders.

Results
During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93–1.27) per 5 µg/m3 for 2010 exposure and 1.06 (95% CI: 0.99–1.14) for baseline exposure. Effect estimates for NO2, BC and O3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00–1.16 per 10 ng/m3).

Conclusions
We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.

Original language	English
Pages (from-to)	1499-1507
Number of pages	9
Journal	British Journal of Cancer
Volume	126
Issue number	10
DOIs	https://doi.org/10.1038/s41416-022-01735-4
Publication status	Published - 2022

Bibliographical note

Times Cited: 0 Cited Reference Count: 0 Chen, Jie Rodopoulou, Sophia Strak, Maciej de Hoogh, Kees Taj, Tahir Poulsen, Aslak Harbo Andersen, Zorana J. Bellander, Tom Brandt, Jorgen Zitt, Emanuel Fecht, Daniela Forastiere, Francesco Gulliver, John Hertel, Ole Hoffmann, Barbara Hvidtfeldt, Ulla Arthur Verschuren, W. M. Monique Jorgensen, Jeanette T. Katsouyanni, Klea Ketzel, Matthias Lager, Anton Leander, Karin Liu, Shuo Ljungman, Petter Severi, Gianluca Boutron-Ruault, Marie-Christine Magnusson, Patrik K. E. Nagel, Gabriele Pershagen, Goran Peters, Annette Rizzuto, Debora van der Schouw, Yvonne T. Samoli, Evangelia Sorensen, Mette Stafoggia, Massimo Tjonneland, Anne Weinmayr, Gudrun Wolf, Kathrin Brunekreef, Bert Raaschou-Nielsen, Ole Hoek, Gerard Boutron-Ruault, Marie-Christine/H-3936-2014; Joergensen, Jeanette/AAC-2884-2020; Severi, Gianluca/H-3774-2018; Chen, Jie/AFN-2387-2022; KETZEL, Matthias/K-4246-2015; de Hoogh, Kees/ABE-1274-2021; Lager, Anton/AAD-1124-2020; Leander, Karin/C-7261-2017; Breteler, Monique/J-5058-2014; Stafoggia, Massimo/K-2261-2016; brunekreef, bert/ACN-0336-2022; van der Schouw, Yvonne/F-8327-2014; , Daniela/HRD-8206-2023; Magnusson, Patrik/C-4458-2017; Zitt, Emanuel/ABE-1926-2020; Hertel, Ole/L-4346-2013; Rizzuto, Debora/V-1890-2018; Tjonneland, Anne/AGU-0320-2022; Ljungman, Petter/C-6371-2014; Wolf, Kathrin/I-4461-2017; Brandt, Jørgen/B-3733-2011; Peters, Annette/A-6117-2011; Andersen, Zorana Jovanovic/P-4983-2014; Hertel, Ole/GOK-0338-2022 Chen, Jie/0000-0001-9644-8026; KETZEL, Matthias/0000-0001-9519-1935; Gulliver, John/0000-0003-3423-2013; Hertel, Ole/0000-0003-0972-7735; Rizzuto, Debora/0000-0001-6199-9629; , Evangelia/0000-0002-9266-9929; taj, tahir/0009-0001-6263-2615; Tjonneland, Anne/0000-0003-4385-2097; Ljungman, Petter/0000-0002-7815-2632; Wolf, Kathrin/0000-0002-4343-201X; Brandt, Jørgen/0000-0002-7580-9547; Poulsen, Aslak/0000-0003-4456-4169; Peters, Annette/0000-0001-6645-0985; Andersen, Zorana Jovanovic/0000-0003-4138-9828; Hertel, Ole/0000-0003-0972-7735 1532-1827

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/s41416-022-01735-4

s41416-022-01735-4Final published version, 781 KBLicence: Taverne

Cite this

Chen, J., Rodopoulou, S., Strak, M., de Hoogh, K., Taj, T., Poulsen, AH., Andersen, ZJ., Bellander, T., Brandt, J., Zitt, E., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Hvidtfeldt, UA., Verschuren, WMM., Jorgensen, JT., Katsouyanni, K., ... Hoek, G. (2022). Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project. British Journal of Cancer, 126(10), 1499-1507. https://doi.org/10.1038/s41416-022-01735-4

@article{cb06382acaa04feca5bb43ee127116a9,

title = "Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project",

abstract = "Background The evidence linking ambient air pollution to bladder cancer is limited and mixed. Methods We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders. Results During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95\% confidence interval (CI): 0.93–1.27) per 5 µg/m3 for 2010 exposure and 1.06 (95\% CI: 0.99–1.14) for baseline exposure. Effect estimates for NO2, BC and O3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95\% CI: 1.00–1.16 per 10 ng/m3). Conclusions We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.",

author = "J Chen and S Rodopoulou and M Strak and \{de Hoogh\}, K and T Taj and AH Poulsen and ZJ Andersen and T Bellander and J Brandt and E Zitt and D Fecht and F Forastiere and J Gulliver and O Hertel and B Hoffmann and UA Hvidtfeldt and WMM Verschuren and JT Jorgensen and K Katsouyanni and M Ketzel and A Lager and K Leander and S Liu and P Ljungman and G Severi and MC Boutron-Ruault and PKE Magnusson and G Nagel and G Pershagen and A Peters and D Rizzuto and \{van der Schouw\}, YT and E Samoli and M Sorensen and M Stafoggia and A Tjonneland and G Weinmayr and K Wolf and B Brunekreef and O Raaschou-Nielsen and G Hoek",

note = "Times Cited: 0 Cited Reference Count: 0 Chen, Jie Rodopoulou, Sophia Strak, Maciej de Hoogh, Kees Taj, Tahir Poulsen, Aslak Harbo Andersen, Zorana J. Bellander, Tom Brandt, Jorgen Zitt, Emanuel Fecht, Daniela Forastiere, Francesco Gulliver, John Hertel, Ole Hoffmann, Barbara Hvidtfeldt, Ulla Arthur Verschuren, W. M. Monique Jorgensen, Jeanette T. Katsouyanni, Klea Ketzel, Matthias Lager, Anton Leander, Karin Liu, Shuo Ljungman, Petter Severi, Gianluca Boutron-Ruault, Marie-Christine Magnusson, Patrik K. E. Nagel, Gabriele Pershagen, Goran Peters, Annette Rizzuto, Debora van der Schouw, Yvonne T. Samoli, Evangelia Sorensen, Mette Stafoggia, Massimo Tjonneland, Anne Weinmayr, Gudrun Wolf, Kathrin Brunekreef, Bert Raaschou-Nielsen, Ole Hoek, Gerard Boutron-Ruault, Marie-Christine/H-3936-2014; Joergensen, Jeanette/AAC-2884-2020; Severi, Gianluca/H-3774-2018; Chen, Jie/AFN-2387-2022; KETZEL, Matthias/K-4246-2015; de Hoogh, Kees/ABE-1274-2021; Lager, Anton/AAD-1124-2020; Leander, Karin/C-7261-2017; Breteler, Monique/J-5058-2014; Stafoggia, Massimo/K-2261-2016; brunekreef, bert/ACN-0336-2022; van der Schouw, Yvonne/F-8327-2014; , Daniela/HRD-8206-2023; Magnusson, Patrik/C-4458-2017; Zitt, Emanuel/ABE-1926-2020; Hertel, Ole/L-4346-2013; Rizzuto, Debora/V-1890-2018; Tjonneland, Anne/AGU-0320-2022; Ljungman, Petter/C-6371-2014; Wolf, Kathrin/I-4461-2017; Brandt, J{\o}rgen/B-3733-2011; Peters, Annette/A-6117-2011; Andersen, Zorana Jovanovic/P-4983-2014; Hertel, Ole/GOK-0338-2022 Chen, Jie/0000-0001-9644-8026; KETZEL, Matthias/0000-0001-9519-1935; Gulliver, John/0000-0003-3423-2013; Hertel, Ole/0000-0003-0972-7735; Rizzuto, Debora/0000-0001-6199-9629; , Evangelia/0000-0002-9266-9929; taj, tahir/0009-0001-6263-2615; Tjonneland, Anne/0000-0003-4385-2097; Ljungman, Petter/0000-0002-7815-2632; Wolf, Kathrin/0000-0002-4343-201X; Brandt, J{\o}rgen/0000-0002-7580-9547; Poulsen, Aslak/0000-0003-4456-4169; Peters, Annette/0000-0001-6645-0985; Andersen, Zorana Jovanovic/0000-0003-4138-9828; Hertel, Ole/0000-0003-0972-7735 1532-1827",

year = "2022",

doi = "10.1038/s41416-022-01735-4",

language = "English",

volume = "126",

pages = "1499--1507",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "10",

}

Chen, J, Rodopoulou, S, Strak, M, de Hoogh, K, Taj, T, Poulsen, AH, Andersen, ZJ, Bellander, T, Brandt, J, Zitt, E, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, UA, Verschuren, WMM, Jorgensen, JT, Katsouyanni, K, Ketzel, M, Lager, A, Leander, K, Liu, S, Ljungman, P, Severi, G, Boutron-Ruault, MC, Magnusson, PKE, Nagel, G, Pershagen, G, Peters, A, Rizzuto, D, van der Schouw, YT, Samoli, E, Sorensen, M, Stafoggia, M, Tjonneland, A, Weinmayr, G, Wolf, K, Brunekreef, B, Raaschou-Nielsen, O & Hoek, G 2022, 'Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project', British Journal of Cancer, vol. 126, no. 10, pp. 1499-1507. https://doi.org/10.1038/s41416-022-01735-4

TY - JOUR

T1 - Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

AU - Chen, J

AU - Rodopoulou, S

AU - Strak, M

AU - de Hoogh, K

AU - Taj, T

AU - Poulsen, AH

AU - Andersen, ZJ

AU - Bellander, T

AU - Brandt, J

AU - Zitt, E

AU - Fecht, D

AU - Forastiere, F

AU - Gulliver, J

AU - Hertel, O

AU - Hoffmann, B

AU - Hvidtfeldt, UA

AU - Verschuren, WMM

AU - Jorgensen, JT

AU - Katsouyanni, K

AU - Ketzel, M

AU - Lager, A

AU - Leander, K

AU - Liu, S

AU - Ljungman, P

AU - Severi, G

AU - Boutron-Ruault, MC

AU - Magnusson, PKE

AU - Nagel, G

AU - Pershagen, G

AU - Peters, A

AU - Rizzuto, D

AU - van der Schouw, YT

AU - Samoli, E

AU - Sorensen, M

AU - Stafoggia, M

AU - Tjonneland, A

AU - Weinmayr, G

AU - Wolf, K

AU - Brunekreef, B

AU - Raaschou-Nielsen, O

AU - Hoek, G

N1 - Times Cited: 0 Cited Reference Count: 0 Chen, Jie Rodopoulou, Sophia Strak, Maciej de Hoogh, Kees Taj, Tahir Poulsen, Aslak Harbo Andersen, Zorana J. Bellander, Tom Brandt, Jorgen Zitt, Emanuel Fecht, Daniela Forastiere, Francesco Gulliver, John Hertel, Ole Hoffmann, Barbara Hvidtfeldt, Ulla Arthur Verschuren, W. M. Monique Jorgensen, Jeanette T. Katsouyanni, Klea Ketzel, Matthias Lager, Anton Leander, Karin Liu, Shuo Ljungman, Petter Severi, Gianluca Boutron-Ruault, Marie-Christine Magnusson, Patrik K. E. Nagel, Gabriele Pershagen, Goran Peters, Annette Rizzuto, Debora van der Schouw, Yvonne T. Samoli, Evangelia Sorensen, Mette Stafoggia, Massimo Tjonneland, Anne Weinmayr, Gudrun Wolf, Kathrin Brunekreef, Bert Raaschou-Nielsen, Ole Hoek, Gerard Boutron-Ruault, Marie-Christine/H-3936-2014; Joergensen, Jeanette/AAC-2884-2020; Severi, Gianluca/H-3774-2018; Chen, Jie/AFN-2387-2022; KETZEL, Matthias/K-4246-2015; de Hoogh, Kees/ABE-1274-2021; Lager, Anton/AAD-1124-2020; Leander, Karin/C-7261-2017; Breteler, Monique/J-5058-2014; Stafoggia, Massimo/K-2261-2016; brunekreef, bert/ACN-0336-2022; van der Schouw, Yvonne/F-8327-2014; , Daniela/HRD-8206-2023; Magnusson, Patrik/C-4458-2017; Zitt, Emanuel/ABE-1926-2020; Hertel, Ole/L-4346-2013; Rizzuto, Debora/V-1890-2018; Tjonneland, Anne/AGU-0320-2022; Ljungman, Petter/C-6371-2014; Wolf, Kathrin/I-4461-2017; Brandt, Jørgen/B-3733-2011; Peters, Annette/A-6117-2011; Andersen, Zorana Jovanovic/P-4983-2014; Hertel, Ole/GOK-0338-2022 Chen, Jie/0000-0001-9644-8026; KETZEL, Matthias/0000-0001-9519-1935; Gulliver, John/0000-0003-3423-2013; Hertel, Ole/0000-0003-0972-7735; Rizzuto, Debora/0000-0001-6199-9629; , Evangelia/0000-0002-9266-9929; taj, tahir/0009-0001-6263-2615; Tjonneland, Anne/0000-0003-4385-2097; Ljungman, Petter/0000-0002-7815-2632; Wolf, Kathrin/0000-0002-4343-201X; Brandt, Jørgen/0000-0002-7580-9547; Poulsen, Aslak/0000-0003-4456-4169; Peters, Annette/0000-0001-6645-0985; Andersen, Zorana Jovanovic/0000-0003-4138-9828; Hertel, Ole/0000-0003-0972-7735 1532-1827

PY - 2022

Y1 - 2022

N2 - Background The evidence linking ambient air pollution to bladder cancer is limited and mixed. Methods We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders. Results During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93–1.27) per 5 µg/m3 for 2010 exposure and 1.06 (95% CI: 0.99–1.14) for baseline exposure. Effect estimates for NO2, BC and O3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00–1.16 per 10 ng/m3). Conclusions We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.

AB - Background The evidence linking ambient air pollution to bladder cancer is limited and mixed. Methods We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders. Results During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93–1.27) per 5 µg/m3 for 2010 exposure and 1.06 (95% CI: 0.99–1.14) for baseline exposure. Effect estimates for NO2, BC and O3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00–1.16 per 10 ng/m3). Conclusions We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.

U2 - 10.1038/s41416-022-01735-4

DO - 10.1038/s41416-022-01735-4

M3 - Article

SN - 0007-0920

VL - 126

SP - 1499

EP - 1507

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

Abstract

Bibliographical note

UN SDGs

Access to Document

Fingerprint

Cite this