Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project

Gabriele Nagel; Jie Chen; Andrea Jaensch; Lea Skodda; Sophia Rodopoulou; Maciej Strak; Kees de Hoogh; Zorana J Andersen; Tom Bellander; Jørgen Brandt; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara Hoffmann; Ulla Arthur Hvidtfeldt; Klea Katsouyanni; Matthias Ketzel; Karin Leander; Patrik K E Magnusson; Göran Pershagen; Debora Rizzuto; Evangelia Samoli; Gianluca Severi; Massimo Stafoggia; Anne Tjønneland; Roel C H Vermeulen; Kathrin Wolf; Emanuel Zitt; Bert Brunekreef; Gerard Hoek; Ole Raaschou-Nielsen; Gudrun Weinmayr

doi:10.1002/ijc.34864

Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project

Gabriele Nagel^*, Jie Chen, Andrea Jaensch, Lea Skodda, Sophia Rodopoulou, Maciej Strak, Kees de Hoogh, Zorana J Andersen, Tom Bellander, Jørgen Brandt, Daniela Fecht, Francesco Forastiere, John Gulliver, Ole Hertel, Barbara Hoffmann, Ulla Arthur Hvidtfeldt, Klea Katsouyanni, Matthias Ketzel, Karin Leander, Patrik K E MagnussonGöran Pershagen, Debora Rizzuto, Evangelia Samoli, Gianluca Severi, Massimo Stafoggia, Anne Tjønneland, Roel C H Vermeulen, Kathrin Wolf, Emanuel Zitt, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen, Gudrun Weinmayr

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM 2.5 ), nitrogen dioxide (NO 2 ), black carbon (BC) and ozone in the warm season (O 3w ) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM 2.5 , NO 2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00-1.33) per 5 μg/m 3 increase in PM 2.5 , 1.19 (1.08-1.30) per 10 μg/m 3 increase in NO 2 , 1.14 (1.04-1.26) per 0.5 × 10 -5 m -1 increase in BC and 0.81 (0.72-0.92) per 10 μg/m 3 increase in O 3w . We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM 2.5 , NO 2 and BC increased incidence of UADT cancer was observed.

Original language	English
Pages (from-to)	1900-1910
Number of pages	11
Journal	International Journal of Cancer
Volume	154
Issue number	11
Early online date	10 Feb 2024
DOIs	https://doi.org/10.1002/ijc.34864
Publication status	Published - Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

Funding

The research described in this article was conducted under contract with the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R‐82811201) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI, or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers. The analyses on gastric and UADT were supported by the German Cancer Aid (Project No. 7011460).

Funders	Funder number
U.S. Environmental Protection Agency	R‐82811201
U.S. Environmental Protection Agency
Health Effects Institute
Deutsche Krebshilfe	7011460
Deutsche Krebshilfe

Keywords

UADT
air pollution
gastric cancer
nitrogen dioxide
ozone
particular matter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Intl Journal of Cancer - 2024 - Nagel - Long‐term exposure to air pollution and incidence of gastric and the upperFinal published version, 3.26 MBLicence: CC BY

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Nagel, G., Chen, J., Jaensch, A., Skodda, L., Rodopoulou, S., Strak, M., de Hoogh, K., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Hvidtfeldt, U. A., Katsouyanni, K., Ketzel, M., Leander, K., ... Weinmayr, G. (2024). Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project. International Journal of Cancer, 154(11), 1900-1910. https://doi.org/10.1002/ijc.34864

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abstract = "Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM 2.5 ), nitrogen dioxide (NO 2 ), black carbon (BC) and ozone in the warm season (O 3w ) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM 2.5 , NO 2 and BC while for UADT the hazard ratios (95\% confidence interval) were 1.15 (95\% CI: 1.00-1.33) per 5 μg/m 3 increase in PM 2.5 , 1.19 (1.08-1.30) per 10 μg/m 3 increase in NO 2 , 1.14 (1.04-1.26) per 0.5 × 10 -5 m -1 increase in BC and 0.81 (0.72-0.92) per 10 μg/m 3 increase in O 3w . We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM 2.5 , NO 2 and BC increased incidence of UADT cancer was observed. ",

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author = "Gabriele Nagel and Jie Chen and Andrea Jaensch and Lea Skodda and Sophia Rodopoulou and Maciej Strak and \{de Hoogh\}, Kees and Andersen, \{Zorana J\} and Tom Bellander and J{\o}rgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and Hvidtfeldt, \{Ulla Arthur\} and Klea Katsouyanni and Matthias Ketzel and Karin Leander and Magnusson, \{Patrik K E\} and G{\"o}ran Pershagen and Debora Rizzuto and Evangelia Samoli and Gianluca Severi and Massimo Stafoggia and Anne Tj{\o}nneland and Vermeulen, \{Roel C H\} and Kathrin Wolf and Emanuel Zitt and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen and Gudrun Weinmayr",

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Nagel, G, Chen, J, Jaensch, A, Skodda, L, Rodopoulou, S, Strak, M, de Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, UA, Katsouyanni, K, Ketzel, M, Leander, K, Magnusson, PKE, Pershagen, G, Rizzuto, D, Samoli, E, Severi, G, Stafoggia, M, Tjønneland, A, Vermeulen, RCH, Wolf, K, Zitt, E, Brunekreef, B , Hoek, G, Raaschou-Nielsen, O & Weinmayr, G 2024, 'Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project', International Journal of Cancer, vol. 154, no. 11, pp. 1900-1910. https://doi.org/10.1002/ijc.34864

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T1 - Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort

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AU - Nagel, Gabriele

AU - Chen, Jie

AU - Jaensch, Andrea

AU - Skodda, Lea

AU - Rodopoulou, Sophia

AU - Strak, Maciej

AU - de Hoogh, Kees

AU - Andersen, Zorana J

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla Arthur

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Leander, Karin

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AU - Samoli, Evangelia

AU - Severi, Gianluca

AU - Stafoggia, Massimo

AU - Tjønneland, Anne

AU - Vermeulen, Roel C H

AU - Wolf, Kathrin

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Weinmayr, Gudrun

PY - 2024/6

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N2 - Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM 2.5 ), nitrogen dioxide (NO 2 ), black carbon (BC) and ozone in the warm season (O 3w ) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM 2.5 , NO 2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00-1.33) per 5 μg/m 3 increase in PM 2.5 , 1.19 (1.08-1.30) per 10 μg/m 3 increase in NO 2 , 1.14 (1.04-1.26) per 0.5 × 10 -5 m -1 increase in BC and 0.81 (0.72-0.92) per 10 μg/m 3 increase in O 3w . We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM 2.5 , NO 2 and BC increased incidence of UADT cancer was observed.

AB - Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM 2.5 ), nitrogen dioxide (NO 2 ), black carbon (BC) and ozone in the warm season (O 3w ) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM 2.5 , NO 2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00-1.33) per 5 μg/m 3 increase in PM 2.5 , 1.19 (1.08-1.30) per 10 μg/m 3 increase in NO 2 , 1.14 (1.04-1.26) per 0.5 × 10 -5 m -1 increase in BC and 0.81 (0.72-0.92) per 10 μg/m 3 increase in O 3w . We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM 2.5 , NO 2 and BC increased incidence of UADT cancer was observed.

KW - UADT

KW - air pollution

KW - gastric cancer

KW - nitrogen dioxide

KW - ozone

KW - particular matter

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DO - 10.1002/ijc.34864

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SN - 0020-7136

VL - 154

SP - 1900

EP - 1910

JO - International Journal of Cancer

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ER -

Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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