Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

J. Prickaerts; E.T. Gieling; A.K. Bruder; F.J. van der Staay; T. Vanmierlo

doi:10.1016/j.ijdevneu.2013.11.001

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

J. Prickaerts, E.T. Gieling, A.K. Bruder, F.J. van der Staay, T. Vanmierlo

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Abstract

In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression
of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets.
ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal
plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker
PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a
similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered
in the last trimester might be a promising treatment for LBW neonates.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	International Journal of Developmental Neuroscience
Volume	33
DOIs	https://doi.org/10.1016/j.ijdevneu.2013.11.001
Publication status	Published - 2014

Keywords

Allopurinol
Low birth weight
BDNF
Neuronal plasticity
Pig

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title = "Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets",

abstract = "In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expressionof plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets.ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronalplasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic markerPSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to asimilar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administeredin the last trimester might be a promising treatment for LBW neonates.",

keywords = "Allopurinol, Low birth weight, BDNF, Neuronal plasticity, Pig",

author = "J. Prickaerts and E.T. Gieling and A.K. Bruder and {van der Staay}, F.J. and T. Vanmierlo",

year = "2014",

doi = "10.1016/j.ijdevneu.2013.11.001",

language = "English",

volume = "33",

pages = "29--32",

journal = "International Journal of Developmental Neuroscience",

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T1 - Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

AU - Prickaerts, J.

AU - Gieling, E.T.

AU - Bruder, A.K.

AU - van der Staay, F.J.

AU - Vanmierlo, T.

PY - 2014

Y1 - 2014

N2 - In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expressionof plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets.ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronalplasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic markerPSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to asimilar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administeredin the last trimester might be a promising treatment for LBW neonates.

AB - In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expressionof plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets.ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronalplasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic markerPSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to asimilar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administeredin the last trimester might be a promising treatment for LBW neonates.

KW - Allopurinol

KW - Low birth weight

KW - BDNF

KW - Neuronal plasticity

KW - Pig

U2 - 10.1016/j.ijdevneu.2013.11.001

DO - 10.1016/j.ijdevneu.2013.11.001

M3 - Article

SN - 0736-5748

VL - 33

SP - 29

EP - 32

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

ER -

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

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Keywords

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