Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Regina Hampel; Annette Peters; Rob Beelen; Bert Brunekreef; Josef Cyrys; Ulf de Faire; Kees de Hoogh; Kateryna Fuks; Barbara Hoffmann; Anke Hüls; Medea Imboden; Aleksandra Jedynska; Ingeborg Kooter; Wolfgang Koenig; Nino Künzli; Karin Leander; Patrik Magnusson; Satu Männistö; Johanna Penell; Göran Pershagen; Harish Phuleria; Nicole Probst-Hensch; Noreen Pundt; Emmanuel Schaffner; Tamara Schikowski; Dorothea Sugiri; Pekka Tiittanen; Ming-Yi Tsai; Meng Wang; Kathrin Wolf; Timo Lanki; ESCAPE TRANSPHORM study groups

doi:10.1016/j.envint.2015.05.008

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Regina Hampel
, Annette Peters
, Rob Beelen
, Bert Brunekreef
, Josef Cyrys
, Ulf de Faire
, Kees de Hoogh
, Kateryna Fuks
, Barbara Hoffmann
, Anke Hüls
, Medea Imboden
, Aleksandra Jedynska
, Ingeborg Kooter
, Wolfgang Koenig
, Nino Künzli
, Karin Leander
, Patrik Magnusson
, Satu Männistö
, Johanna Penell
, Göran Pershagen

Harish Phuleria, Nicole Probst-Hensch, Noreen Pundt, Emmanuel Schaffner, Tamara Schikowski, Dorothea Sugiri, Pekka Tiittanen, Ming-Yi Tsai, Meng Wang, Kathrin Wolf, Timo Lanki, ESCAPE TRANSPHORM study groups

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.

OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.

METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.

RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.

CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

Original language	English
Pages (from-to)	76-84
Number of pages	9
Journal	Environment international
Volume	82
DOIs	https://doi.org/10.1016/j.envint.2015.05.008
Publication status	Published - Sept 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 15 Life on Land

Keywords

Long-term exposure
Particulate matter
Elemental components
Inflammation
ESCAPE
TRANSPHORM

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10.1016/j.envint.2015.05.008

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Hampel, R., Peters, A., Beelen, R., Brunekreef, B., Cyrys, J., de Faire, U., de Hoogh, K., Fuks, K., Hoffmann, B., Hüls, A., Imboden, M., Jedynska, A., Kooter, I., Koenig, W., Künzli, N., Leander, K., Magnusson, P., Männistö, S., Penell, J., ... ESCAPE TRANSPHORM study groups (2015). Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environment international, 82, 76-84. https://doi.org/10.1016/j.envint.2015.05.008

@article{a38034e1f2f84cb588506e81890b5a04,

title = "Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts",

abstract = "BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3\% [0.7; 12.3\%] and 3.6\% [0.3; 7.1\%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2\% [0.1; 2.4\%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.",

keywords = "Long-term exposure, Particulate matter, Elemental components, Inflammation, ESCAPE, TRANSPHORM",

author = "Regina Hampel and Annette Peters and Rob Beelen and Bert Brunekreef and Josef Cyrys and \{de Faire\}, Ulf and \{de Hoogh\}, Kees and Kateryna Fuks and Barbara Hoffmann and Anke H{\"u}ls and Medea Imboden and Aleksandra Jedynska and Ingeborg Kooter and Wolfgang Koenig and Nino K{\"u}nzli and Karin Leander and Patrik Magnusson and Satu M{\"a}nnist{\"o} and Johanna Penell and G{\"o}ran Pershagen and Harish Phuleria and Nicole Probst-Hensch and Noreen Pundt and Emmanuel Schaffner and Tamara Schikowski and Dorothea Sugiri and Pekka Tiittanen and Ming-Yi Tsai and Meng Wang and Kathrin Wolf and Timo Lanki and \{ESCAPE TRANSPHORM study groups\}",

year = "2015",

month = sep,

doi = "10.1016/j.envint.2015.05.008",

language = "English",

volume = "82",

pages = "76--84",

journal = "Environment international",

issn = "0160-4120",

publisher = "Elsevier Limited",

}

Hampel, R, Peters, A, Beelen, R, Brunekreef, B, Cyrys, J, de Faire, U, de Hoogh, K, Fuks, K, Hoffmann, B, Hüls, A, Imboden, M, Jedynska, A, Kooter, I, Koenig, W, Künzli, N, Leander, K, Magnusson, P, Männistö, S, Penell, J, Pershagen, G, Phuleria, H, Probst-Hensch, N, Pundt, N, Schaffner, E, Schikowski, T, Sugiri, D, Tiittanen, P, Tsai, M-Y, Wang, M, Wolf, K, Lanki, T & ESCAPE TRANSPHORM study groups 2015, 'Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts', Environment international, vol. 82, pp. 76-84. https://doi.org/10.1016/j.envint.2015.05.008

TY - JOUR

T1 - Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

AU - Hampel, Regina

AU - Peters, Annette

AU - Beelen, Rob

AU - Brunekreef, Bert

AU - Cyrys, Josef

AU - de Faire, Ulf

AU - de Hoogh, Kees

AU - Fuks, Kateryna

AU - Hoffmann, Barbara

AU - Hüls, Anke

AU - Imboden, Medea

AU - Jedynska, Aleksandra

AU - Kooter, Ingeborg

AU - Koenig, Wolfgang

AU - Künzli, Nino

AU - Leander, Karin

AU - Magnusson, Patrik

AU - Männistö, Satu

AU - Penell, Johanna

AU - Pershagen, Göran

AU - Phuleria, Harish

AU - Probst-Hensch, Nicole

AU - Pundt, Noreen

AU - Schaffner, Emmanuel

AU - Schikowski, Tamara

AU - Sugiri, Dorothea

AU - Tiittanen, Pekka

AU - Tsai, Ming-Yi

AU - Wang, Meng

AU - Wolf, Kathrin

AU - Lanki, Timo

AU - ESCAPE TRANSPHORM study groups

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

AB - BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

KW - Long-term exposure

KW - Particulate matter

KW - Elemental components

KW - Inflammation

KW - ESCAPE

KW - TRANSPHORM

U2 - 10.1016/j.envint.2015.05.008

DO - 10.1016/j.envint.2015.05.008

M3 - Article

C2 - 26057255

SN - 0160-4120

VL - 82

SP - 76

EP - 84

JO - Environment international

JF - Environment international

ER -

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Abstract

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Keywords

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