Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Regina Hampel; Annette Peters; Rob Beelen; Bert Brunekreef; Josef Cyrys; Ulf de Faire; Kees de Hoogh; Kateryna Fuks; Barbara Hoffmann; Anke Hüls; Medea Imboden; Aleksandra Jedynska; Ingeborg Kooter; Wolfgang Koenig; Nino Künzli; Karin Leander; Patrik Magnusson; Satu Männistö; Johanna Penell; Göran Pershagen; Harish Phuleria; Nicole Probst-Hensch; Noreen Pundt; Emmanuel Schaffner; Tamara Schikowski; Dorothea Sugiri; Pekka Tiittanen; Ming-Yi Tsai; Meng Wang; Kathrin Wolf; Timo Lanki; ESCAPE TRANSPHORM study groups

doi:10.1016/j.envint.2015.05.008

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Regina Hampel, Annette Peters, Rob Beelen, Bert Brunekreef, Josef Cyrys, Ulf de Faire, Kees de Hoogh, Kateryna Fuks, Barbara Hoffmann, Anke Hüls, Medea Imboden, Aleksandra Jedynska, Ingeborg Kooter, Wolfgang Koenig, Nino Künzli, Karin Leander, Patrik Magnusson, Satu Männistö, Johanna Penell, Göran PershagenHarish Phuleria, Nicole Probst-Hensch, Noreen Pundt, Emmanuel Schaffner, Tamara Schikowski, Dorothea Sugiri, Pekka Tiittanen, Ming-Yi Tsai, Meng Wang, Kathrin Wolf, Timo Lanki, ESCAPE TRANSPHORM study groups

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.

OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.

METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.

RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.

CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

Original language	English
Pages (from-to)	76-84
Number of pages	9
Journal	Environment international
Volume	82
DOIs	https://doi.org/10.1016/j.envint.2015.05.008
Publication status	Published - Sept 2015

Keywords

Long-term exposure
Particulate matter
Elemental components
Inflammation
ESCAPE
TRANSPHORM

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Hampel, R., Peters, A., Beelen, R., Brunekreef, B., Cyrys, J., de Faire, U., de Hoogh, K., Fuks, K., Hoffmann, B., Hüls, A., Imboden, M., Jedynska, A., Kooter, I., Koenig, W., Künzli, N., Leander, K., Magnusson, P., Männistö, S., Penell, J., ... ESCAPE TRANSPHORM study groups (2015). Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environment international, 82, 76-84. https://doi.org/10.1016/j.envint.2015.05.008

@article{a38034e1f2f84cb588506e81890b5a04,

title = "Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts",

abstract = "BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.",

keywords = "Long-term exposure, Particulate matter, Elemental components, Inflammation, ESCAPE, TRANSPHORM",

author = "Regina Hampel and Annette Peters and Rob Beelen and Bert Brunekreef and Josef Cyrys and {de Faire}, Ulf and {de Hoogh}, Kees and Kateryna Fuks and Barbara Hoffmann and Anke H{\"u}ls and Medea Imboden and Aleksandra Jedynska and Ingeborg Kooter and Wolfgang Koenig and Nino K{\"u}nzli and Karin Leander and Patrik Magnusson and Satu M{\"a}nnist{\"o} and Johanna Penell and G{\"o}ran Pershagen and Harish Phuleria and Nicole Probst-Hensch and Noreen Pundt and Emmanuel Schaffner and Tamara Schikowski and Dorothea Sugiri and Pekka Tiittanen and Ming-Yi Tsai and Meng Wang and Kathrin Wolf and Timo Lanki and {ESCAPE TRANSPHORM study groups}",

year = "2015",

month = sep,

doi = "10.1016/j.envint.2015.05.008",

language = "English",

volume = "82",

pages = "76--84",

journal = "Environment international",

issn = "0160-4120",

publisher = "Elsevier Limited",

}

Hampel, R, Peters, A, Beelen, R, Brunekreef, B, Cyrys, J, de Faire, U, de Hoogh, K, Fuks, K, Hoffmann, B, Hüls, A, Imboden, M, Jedynska, A, Kooter, I, Koenig, W, Künzli, N, Leander, K, Magnusson, P, Männistö, S, Penell, J, Pershagen, G, Phuleria, H, Probst-Hensch, N, Pundt, N, Schaffner, E, Schikowski, T, Sugiri, D, Tiittanen, P, Tsai, M-Y, Wang, M, Wolf, K, Lanki, T & ESCAPE TRANSPHORM study groups 2015, 'Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts', Environment international, vol. 82, pp. 76-84. https://doi.org/10.1016/j.envint.2015.05.008

TY - JOUR

T1 - Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

AU - Hampel, Regina

AU - Peters, Annette

AU - Beelen, Rob

AU - Brunekreef, Bert

AU - Cyrys, Josef

AU - de Faire, Ulf

AU - de Hoogh, Kees

AU - Fuks, Kateryna

AU - Hoffmann, Barbara

AU - Hüls, Anke

AU - Imboden, Medea

AU - Jedynska, Aleksandra

AU - Kooter, Ingeborg

AU - Koenig, Wolfgang

AU - Künzli, Nino

AU - Leander, Karin

AU - Magnusson, Patrik

AU - Männistö, Satu

AU - Penell, Johanna

AU - Pershagen, Göran

AU - Phuleria, Harish

AU - Probst-Hensch, Nicole

AU - Pundt, Noreen

AU - Schaffner, Emmanuel

AU - Schikowski, Tamara

AU - Sugiri, Dorothea

AU - Tiittanen, Pekka

AU - Tsai, Ming-Yi

AU - Wang, Meng

AU - Wolf, Kathrin

AU - Lanki, Timo

AU - ESCAPE TRANSPHORM study groups

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

AB - BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects.METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

KW - Long-term exposure

KW - Particulate matter

KW - Elemental components

KW - Inflammation

KW - ESCAPE

KW - TRANSPHORM

U2 - 10.1016/j.envint.2015.05.008

DO - 10.1016/j.envint.2015.05.008

M3 - Article

C2 - 26057255

SN - 0160-4120

VL - 82

SP - 76

EP - 84

JO - Environment international

JF - Environment international

ER -

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

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Keywords

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