Locoregional cancer therapy using polymer-based drug depots

Farshad Ramazani; Cornelis F. van Nostrum; G Storm; Fabian Kiessling; Twan Lammers; Wim E. Hennink; Robbert J. Kok

doi:10.1016/j.drudis.2016.02.014

Locoregional cancer therapy using polymer-based drug depots

Farshad Ramazani, Cornelis F. van Nostrum, G Storm, Fabian Kiessling, Twan Lammers, Wim E. Hennink, Robbert J. Kok^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Locoregional delivery of anticancer drugs is an attractive approach to minimize adverse effects associated with intravenous chemotherapy. Polymer-based drug depots injected or implanted intratumorally or adjacent to the tumor can provide long-term local drug exposure. This review highlights studies in which drug-eluting depots have been applied locally in the treatment of cancer. In many cases such drug depots are used for prevention of tumor recurrence after surgery to eradicate remaining tumor cells. Clinical success has been reported for the treatment of brain cancer and liver cancer, and preclinical studies showed proof-of-concept for inhaled drug depots in lung cancer and intraperitoneally injected depots for the treatment of abdominal cancer.

Original language	English
Pages (from-to)	640-647
Number of pages	8
Journal	Drug Discovery Today
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.drudis.2016.02.014
Publication status	Published - 2016

Access to Document

10.1016/j.drudis.2016.02.014

locoregionalFinal published version, 0.98 MBLicence: Taverne

Cite this

@article{8e68b28ec9864ee2b517637f80d902b5,

title = "Locoregional cancer therapy using polymer-based drug depots",

abstract = "Locoregional delivery of anticancer drugs is an attractive approach to minimize adverse effects associated with intravenous chemotherapy. Polymer-based drug depots injected or implanted intratumorally or adjacent to the tumor can provide long-term local drug exposure. This review highlights studies in which drug-eluting depots have been applied locally in the treatment of cancer. In many cases such drug depots are used for prevention of tumor recurrence after surgery to eradicate remaining tumor cells. Clinical success has been reported for the treatment of brain cancer and liver cancer, and preclinical studies showed proof-of-concept for inhaled drug depots in lung cancer and intraperitoneally injected depots for the treatment of abdominal cancer.",

author = "Farshad Ramazani and {van Nostrum}, {Cornelis F.} and G Storm and Fabian Kiessling and Twan Lammers and Hennink, {Wim E.} and Kok, {Robbert J.}",

year = "2016",

doi = "10.1016/j.drudis.2016.02.014",

language = "English",

volume = "21",

pages = "640--647",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Locoregional cancer therapy using polymer-based drug depots

AU - Ramazani, Farshad

AU - van Nostrum, Cornelis F.

AU - Storm, G

AU - Kiessling, Fabian

AU - Lammers, Twan

AU - Hennink, Wim E.

AU - Kok, Robbert J.

PY - 2016

Y1 - 2016

N2 - Locoregional delivery of anticancer drugs is an attractive approach to minimize adverse effects associated with intravenous chemotherapy. Polymer-based drug depots injected or implanted intratumorally or adjacent to the tumor can provide long-term local drug exposure. This review highlights studies in which drug-eluting depots have been applied locally in the treatment of cancer. In many cases such drug depots are used for prevention of tumor recurrence after surgery to eradicate remaining tumor cells. Clinical success has been reported for the treatment of brain cancer and liver cancer, and preclinical studies showed proof-of-concept for inhaled drug depots in lung cancer and intraperitoneally injected depots for the treatment of abdominal cancer.

AB - Locoregional delivery of anticancer drugs is an attractive approach to minimize adverse effects associated with intravenous chemotherapy. Polymer-based drug depots injected or implanted intratumorally or adjacent to the tumor can provide long-term local drug exposure. This review highlights studies in which drug-eluting depots have been applied locally in the treatment of cancer. In many cases such drug depots are used for prevention of tumor recurrence after surgery to eradicate remaining tumor cells. Clinical success has been reported for the treatment of brain cancer and liver cancer, and preclinical studies showed proof-of-concept for inhaled drug depots in lung cancer and intraperitoneally injected depots for the treatment of abdominal cancer.

UR - http://www.scopus.com/inward/record.url?scp=84961138326&partnerID=8YFLogxK

U2 - 10.1016/j.drudis.2016.02.014

DO - 10.1016/j.drudis.2016.02.014

M3 - Article

AN - SCOPUS:84961138326

SN - 1359-6446

VL - 21

SP - 640

EP - 647

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 4

ER -

Locoregional cancer therapy using polymer-based drug depots

Abstract

Access to Document

Fingerprint

Cite this