Live imaging of inhibitory axons: Synapse formation as a dynamic trial-and-error process

C.J. Wierenga

doi:10.1016/j.brainresbull.2016.09.018

Live imaging of inhibitory axons: Synapse formation as a dynamic trial-and-error process

C.J. Wierenga^*

^*Corresponding author for this work

Cell Biology, Neurobiology and Biophysics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this review I discuss recent live imaging studies that demonstrate that synapses, and in particular inhibitory synapses, are highly dynamic structures. The ongoing changes of presynaptic boutons within axons emphasize the stochastic aspect of inhibitory synapse formation and paint a picture of a dynamic trial-and-error process. Furthermore, I discuss recent and previous insights in the molecular and mechanistic pathways that underlie synapse formation, with a specific focus on the formation of inhibitory presynaptic boutons.

Original language	English
Pages (from-to)	43-49
Number of pages	7
Journal	Brain Research Bulletin
Volume	129
DOIs	https://doi.org/10.1016/j.brainresbull.2016.09.018
Publication status	Published - 2017

Keywords

Synapse formation
Presynaptic boutons
Live imaging

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10.1016/j.brainresbull.2016.09.018

2017BrResBull reviewFinal published version, 1.18 MBLicence: Taverne

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title = "Live imaging of inhibitory axons: Synapse formation as a dynamic trial-and-error process",

abstract = "In this review I discuss recent live imaging studies that demonstrate that synapses, and in particular inhibitory synapses, are highly dynamic structures. The ongoing changes of presynaptic boutons within axons emphasize the stochastic aspect of inhibitory synapse formation and paint a picture of a dynamic trial-and-error process. Furthermore, I discuss recent and previous insights in the molecular and mechanistic pathways that underlie synapse formation, with a specific focus on the formation of inhibitory presynaptic boutons.",

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author = "C.J. Wierenga",

year = "2017",

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journal = "Brain Research Bulletin",

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PY - 2017

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N2 - In this review I discuss recent live imaging studies that demonstrate that synapses, and in particular inhibitory synapses, are highly dynamic structures. The ongoing changes of presynaptic boutons within axons emphasize the stochastic aspect of inhibitory synapse formation and paint a picture of a dynamic trial-and-error process. Furthermore, I discuss recent and previous insights in the molecular and mechanistic pathways that underlie synapse formation, with a specific focus on the formation of inhibitory presynaptic boutons.

AB - In this review I discuss recent live imaging studies that demonstrate that synapses, and in particular inhibitory synapses, are highly dynamic structures. The ongoing changes of presynaptic boutons within axons emphasize the stochastic aspect of inhibitory synapse formation and paint a picture of a dynamic trial-and-error process. Furthermore, I discuss recent and previous insights in the molecular and mechanistic pathways that underlie synapse formation, with a specific focus on the formation of inhibitory presynaptic boutons.

KW - Synapse formation

KW - Presynaptic boutons

KW - Live imaging

U2 - 10.1016/j.brainresbull.2016.09.018

DO - 10.1016/j.brainresbull.2016.09.018

M3 - Article

SN - 0361-9230

VL - 129

SP - 43

EP - 49

JO - Brain Research Bulletin

JF - Brain Research Bulletin

ER -

Live imaging of inhibitory axons: Synapse formation as a dynamic trial-and-error process

Abstract

Keywords

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