Lithium use and the risk of fractures

Ingeborg Wilting; Frank de Vries; Brahm M K S Thio; Cyrus Cooper; Eibert R Heerdink; Hubert G M Leufkens; Willem A Nolen; Antoine C G Egberts; Tjeerd P van Staa

doi:10.1016/j.bone.2006.12.055

Lithium use and the risk of fractures

Ingeborg Wilting, Frank de Vries, Brahm M K S Thio, Cyrus Cooper, Eibert R Heerdink, Hubert G M Leufkens, Willem A Nolen, Antoine C G Egberts, Tjeerd P van Staa

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.

Original language	English
Pages (from-to)	1252-1258
Number of pages	7
Journal	Bone
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/j.bone.2006.12.055
Publication status	Published - 2007

Keywords

Female
Fractures, Bone
Humans
Lithium
Male
Middle Aged
Questionnaires
Risk Factors

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10.1016/j.bone.2006.12.055

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title = "Lithium use and the risk of fractures",

abstract = "A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.",

keywords = "Female, Fractures, Bone, Humans, Lithium, Male, Middle Aged, Questionnaires, Risk Factors",

author = "Ingeborg Wilting and {de Vries}, Frank and Thio, {Brahm M K S} and Cyrus Cooper and Heerdink, {Eibert R} and Leufkens, {Hubert G M} and Nolen, {Willem A} and Egberts, {Antoine C G} and {van Staa}, {Tjeerd P}",

year = "2007",

doi = "10.1016/j.bone.2006.12.055",

language = "English",

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journal = "Bone",

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T1 - Lithium use and the risk of fractures

AU - Wilting, Ingeborg

AU - de Vries, Frank

AU - Thio, Brahm M K S

AU - Cooper, Cyrus

AU - Heerdink, Eibert R

AU - Leufkens, Hubert G M

AU - Nolen, Willem A

AU - Egberts, Antoine C G

AU - van Staa, Tjeerd P

PY - 2007

Y1 - 2007

N2 - A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.

AB - A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.

KW - Female

KW - Fractures, Bone

KW - Humans

KW - Lithium

KW - Male

KW - Middle Aged

KW - Questionnaires

KW - Risk Factors

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DO - 10.1016/j.bone.2006.12.055

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SN - 8756-3282

VL - 40

SP - 1252

EP - 1258

JO - Bone

JF - Bone

IS - 5

ER -

Lithium use and the risk of fractures

Abstract

Keywords

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